Abstract: Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.

Abstract: Isolated corticotropin releasing factor derivatives, and nucleic acids encoding the same, are effective for treating corticotropin releasing factor 2 receptor modulated disorders such as muscular dystrophy.

Abstract: Process for making 7-cycloamino-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acids. Borate ester compounds suitable for use in such process.

Abstract: Disclosed are oral compositions comprising one or more linear polyphosphates having an average chain length of about 4 or more, sodium monofluorophosphate, a buffering agent, an abrasive polishing material containing less than 23% calcium, and one or more aqueous carriers, wherein the oral composition has a total water content of from about 5% to about 20%.

Abstract: Disclosed are methods for reducing the astringency of dentifrice composition containing stannous comprising administering to the subject a dentifrice composition comprising stannous. The dentifrice composition comprises stannous ions, poloxamer, and aqueous carriers. The efficacy of this dentifrice composition containing stannous will not be reduced by the poloxamer. The dentifrice composition may also contain a polyphosphate as long as the water content is limited and the stannous ion is not provided from stannous fluoride. The polyphosphate will also not reduce the efficacy of the stannous. Alternatively, the dentifrice composition may be a dual phase composition. The first dentifrice composition will contain a polyphosphate having an average chain length of about 4 or more and have a limited water content while the second dentifrice composition will contain stannous ions. In the dual phase composition, the poloxamer will be present in the first or second dentifrice compositions or both compositions.

Abstract: Disclosed are tartar control dentifrice compositions containing certain ranges of thymol. These compositions can also include propylene glycol and/or one or more antibacterial agents.