Abstract: This invention relates to stents having medicated multi-layer hybrid polymer coatings, useful for the treatment of stenosed vasculature or other body passages.

Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Abstract: A barbed suture for connecting tissue, and a combination surgical needle with a barbed suture. The suture includes an elongated body and a plurality of barbs projecting from the body. Each barb causes the suture to resist movement in an opposite direction from which the barb faces. The disposition of the barbs on the body may be staggered, twist cut multiple spiral, overlapping, or random. Also, the configuration of the barbs may be a certain spirality angle ?, barb cut angle ?, barb cut depth, barb cut length, barb cut distance, corrugated barb underside, arcuate barb base, or varying barb size.

Abstract: A suture anchor is provided for approximating tissue to bone or other tissue. The suture anchor comprises an anchor member to fixedly engage the bone for securing the anchor member relative to the bone. A plurality of sutures are mounted to the proximal end of the anchor member so that the sutures extend outwardly from the anchor member. Each suture has a sharp pointed distal end for penetrating the tissue and a plurality of barbs extending from the periphery and disposed along the length of the body of the suture. The barbs permit movement of the sutures through the tissue in a direction of movement of the pointed end and prevent movement of the sutures relative to the tissue in a direction opposite the direction of movement of the pointed end. At least one pointed distal end of at least one suture comprises a needle.

Abstract: A surgical knife blade for forming an incision in bodily tissue including a body having a cutting edge terminating at a distal tip, the cutting edge including opposing cutting edge segments extending distally to meet at the tip, the cutting edge being configured by blending a first and second radii. The first radius is concave and the second radius is convex, the first and second radii meet at a juncture which forms a smooth tangential connection, whereby the blended radii form a hollow design and wherein when the body is moved in a cutting direction transverse to the tissue to cause the tip to enter the tissue, less force is required to penetrate the bodily tissue and greater control is provided.

Abstract: An apparatus for cutting barbs into a suture having a filament supply. The apparatus also has an in-feed collet for holding one end of a filament threaded therethrough. Further the apparatus has an out-feed collet for holding a second end of a filament threaded therethrough. Additionally, the apparatus has a holder positioned between said in-feed and out-feed collets for holding a filament suspended between the in-feed and out-feed collets. The apparatus also has a cutting assembly for cutting barbs in the filament tensioned between the in-feed and out-feed collets.

Abstract: A system for manufacturing self-retaining suture is disclosed. The system includes a cutting bed for creating and supporting a suture during cutting of tissue-grasping elements at different angular positions. A cutting device is moved through the suture thread along a path which can include longitudinal, transverse, oscillating and depth components to create a desired tissue-grasping element on the surface of the suture. The path of the cutting device and the rotation of the suture relative to the cutting device are controlled so that a plurality of angularly-displaced tissue-grasping elements can be created on the suture.

Abstract: A system for manufacturing self-retaining suture includes means for supporting the suture during cutting of retainers which protrude from the suture at multiple angles. The system includes an anvil having a channel configured to support a suture during cutting of a retainer at a first angular position while providing for non-interference between the anvil and retainers previously cut on the suture at one or more angular positions different than the first angular position. In embodiments the channel is provided with notches which receive previously-formed retainers during creation of subsequent retainers. The system thereby provides for rotating the suture and supporting the suture with the anvil without interference with previously-formed retainers.

Abstract: An automated system for manufacturing self-retaining suture is disclosed. The system includes a cutting bed to which a suture is mounted. A power-operated cutting arm moves a cutting device through the suture along a preselected path and at a preselected angle to create a tissue retainer having a desired geometry. An indexing mechanism moves the suture relative to the cutting device. The operation of the cutting arm in conjunction with the geometry of the cutting device and movement of the suture thread allows for creating a plurality of tissue retainers having a desired geometry distributed along the length of the suture thread.

Abstract: A method for manufacturing self-retaining suture is disclosed. The method provides for creating and supporting a suture during cutting of tissue-grasping elements at different angular positions. A cutting device is moved through the suture thread along a path which can include longitudinal, transverse, oscillating and depth components to create a desired tissue-grasping element on the surface of the suture. The path of the cutting device and the rotation of the suture relative to the cutting device are controlled so that a plurality of angularly-displaced tissue-grasping elements can be created on the suture.

Abstract: A method for manufacturing a self-retaining suture is disclosed. A cutting bed supports the suture during cutting. A cutting device is moved through the suture thread along a selected path. The angle of the cutting device is changed during cutting. A cutting arm is articulated to allow change of the angle of the cutting device. The change in the angle of the cutting device is used to control the depth of cut and/or elevate a tissue-retainer away from the suture to better engage tissue.

Abstract: An automated method for manufacturing self-retaining suture is disclosed. The suture is mounted to a support. A power-operated cutting arm moves a cutting device through the suture along a preselected path and at a preselected angle to create a tissue retainer having a desired shape and size. The suture is indexed relative to the cutting device. The operation of the cutting arm in conjunction with the geometry of the cutting device and linear advancement of the suture thread allows for creating a plurality of tissue-retainers having a desired geometry along the length of the suture thread.

Abstract: A system for manufacturing a self-retaining suture is disclosed. The system includes a cutting bed which supports the suture during cutting. A cutting device makes cuts in the suture thread having a preselected geometry. A cutting arm is articulated to allow change of the angle of the cutting device during cutting. The change in the angle of the cutting device is used to control the depth of cut and/or elevate a tissue-retainer away from the suture to better engage tissue.

Abstract: A method of making a barbed suture by varying the blade geometry and/or the movement of the blade when cutting a suture is disclosed. The method can also be accomplished with a cutting device to create a plurality of barbs on the exterior of surgical suture. The barbs produced using the method with the cutting device can be the same or random configurations.

Abstract: Medical devices and methods are provided for a minimally-invasive mastoplasty procedure. In the procedure, barbed sutures are used to accomplish a nipple-lift by deploying the sutures cranially from the nipple-areolar complex to stable anatomical features higher on the chest. Additional barbed sutures may be used to accomplish a breast-lift and/or breast contouring by deploying the sutures caudally from stable anatomical features into the breast tissue.

Abstract: A method is provided for performing a procedure to reposition a portion of a breast using a suture including a plurality of barbs. The barbs on a first portion of the suture adjacent a first end of the suture permit movement of the suture through tissue in a direction of movement of the first end and prevent movement of the suture through tissue in a direction opposite the direction of movement of the first end. The barbs on a second portion of the suture adjacent a second end of the suture permit movement of the suture through tissue in a direction of movement of the second end and prevent movement of the suture through tissue in a direction opposite the direction of movement of the second end.

Abstract: A barbed bodily tissue connector for insertion into tissue comprises an elongated body having a substantially polygonal periphery in cross-section including at least three sides. Each side meets an adjacent side at an edge of the elongated body. A plurality of barbs project from the edges of the body. The barbs are configured such that they are yieldable in a direction toward the body and resist retraction from tissue in an opposite direction.

Abstract: An apparatus for cutting barbs into a suture having a filament supply. The apparatus also has an in-feed collet for holding one end of a filament threaded therethrough. Further the apparatus has an out-feed collet for holding a second end of a filament threaded therethrough. Additionally, the apparatus has a holder positioned between said in-feed and out-feed collets for holding a filament suspended between the in-feed and out-feed collets. The apparatus also has a cutting assembly for cutting barbs in the filament tensioned between the in-feed and out-feed collets.