Abstract: Novel compounds of the formula
or a pharmaceutically acceptable salt or solvate thereof, wherein:
the dotted line represents an optional double bond;
X1 is optionally substituted alkyl, cycloalkyl, aryl, heteroaryl or heterocycloalkyl;
X2 is —CHO, —CN, optionally substituted amino, alkyl, or aryl;
or X1 is optionally substituted benzofused heterocyclyl and X2 is hydrogen;
or X1 and X2 together form an optionally benzofused spiro heterocyclyl group
R1, R2, R3 and R4 are independently H and alkyl, or (R1 and R4) or (R2 and R3) or (R1 and R3) or (R2 and R4) together can form an alkylene bridge of 1 to 3 carbon atoms;
Z1 is optionally substituted alkyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl, or —CO2(alkyl or substituted amino) or CN; Z2 is H or Z1; Z3 is H oralkyl; or Z1, Z2 and Z3, together with the carbon to which they are attached, form bicyclic saturated or unsaturated rings; pharmaceutical compositions therefore, and the use of said compounds as nocicepti
Type:
Grant
Filed:
May 23, 2002
Date of Patent:
April 6, 2004
Assignee:
Schering Corporation
Inventors:
Deen Tulshian, Ginny D. Ho, Lisa S. Silverman, Julius J. Matasi, Robbie L. McLeod, John A. Hey, Richard W. Chapman, Ana Bercovici, Francis M. Cuss