Abstract: Disclosed herein are systems and methods for information organization whereby characteristics regarding entities are inferred from the characteristics of similar entities. This is referred to herein as a “fuzzy similarity join” and is exemplified using a chemical similarity join. The disclosed systems and methods are particularly useful for chemical compound analysis in the area of pharmaceutical development.
Abstract: Disclosed herein are techniques for directly identifying candidate compounds as agonists, partial agonists and/or, most preferably, inverse agonists, to endogenous, constitutively activated orphan G protein-coupled receptors.
Type:
Grant
Filed:
July 30, 1999
Date of Patent:
November 25, 2003
Assignee:
Arena Pharmaceuticals, Inc.
Inventors:
Dominic P. Behan, Derek T. Chalmers, Chen W. Liaw, I Lin-Lin, Kevin P. Lowitz, Ruoping Chen