Abstract: The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
Type:
Grant
Filed:
September 14, 2000
Date of Patent:
April 16, 2002
Assignee:
Apptera Corporation
Inventors:
Linda G. Lee, Ronald J. Graham, William E. Werner, Elana Swartzman, Lily Lu