Patents Represented by Attorney Ann Marie Szezepanik

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  • Screening assay based on the forkhead transcription factor-dependent promoter
    Patent number: 7435868
    Abstract: The invention relates to the identification and use of the DAF-2/IR responsive sod-3 promoter. Transgenic C. elegans containing sod-3 reporter gene constructs are described which are useful for, among other things, the identification of genes or compounds capable of modulating the DAF-2/IR-akt pathway. Conditions are disclosed that increase or decrease the reporter activity, demonstrating the presence of either activators or inhibitors of the DAF-2/IR pathway.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: October 14, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Edmund Hoppe, Ulrike Siebers, Heike Schauerte, Jonathan Rothblatt