Patents Represented by Attorney, Agent or Law Firm Ann Pease
  • Water-soluble rhodamine dyes and conjugates thereof
    Patent number: 6191278
    Abstract: The present invention provides novel, water-soluble, red-emitting fluorescent rhodamine dyes and red-emitting fluorescent energy-transfer dye pairs, as well as labeled conjugates comprising the same and methods for their use. The dyes, energy-transfer dye pairs and labeled conjugates are useful in a variety of aqueous-based applications, particularly in assays involving staining of cells, protein binding, and/or analysis of nucleic acids, such as hybridization assays and nucleic acid sequencing.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: February 20, 2001
    Assignee: PE Corporation
    Inventors: Linda G. Lee, Ronald J. Graham, William E. Werner, Elana Swartzman, Lily Lu
  • Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
    Patent number: 6140500
    Abstract: A new class of red-emitting, fluorescent [8,9]benzophenoxazine dyes are provided that are useful for staining nucleic acids in a variety of contexts, including in solutions, in electrophoretic gels or other matrices, in blotting experiments and in assays employing intact, live cells. The new dyes are brighter and permeate cells faster than currently available red-emitting live-cell nucleic acid stains.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: October 31, 2000
    Assignee: PE Corporation
    Inventors: Xiongwei Yan, Sheri Miragila, Pau Miau Yuan