Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.

Abstract: The present invention provides a novel bioactive compound 12-(12′-CARBOXY-5′-METHOXYPHENYL)-2,12-DIHYDROXY-DODECA-4-ONE “Sporotricolone”, mainly as acetylcholinesterase (AchE) inhibitor, along with a process for the isolation of said compound from fungus Sporotrichum species.

Abstract: A method of manufacture of an electrode formed from at least one electrically conductive polymer having a lower, polymerization potential than p-doping peak. The method of manufacture of the electrode including a conditioning step which results in remarkably high charge capacities and excellent cycling efficiency. The provision of these polymeric electrodes further permits the manufacture of an electrochemical storage cell which is substantially free of metal components, thereby improving handling of the storage cell and obviating safety and environmental concerns associated with alternative secondary battery technology.

Abstract: Pharmaceutical dosage units containing flupirtine or a pharmaceutically acceptable salt of flupirtine with controlled release of active substance using a delayed-action or controlled-release component. There are 0.001 to 20 parts delayed-action component for each part by weight flupirtine (calculated as the base) and the release rate of flupirtine is between 5 and 300 mg per hour. In some cases, the dosage units may also contain a rapidly releasing component of flupirtine or of one of its salts. The dosage units reduce the sedative effect of flupirtine.

Abstract: The present invention relates to allelic variants of human Spinocerebellar ataxia 2 (SCA2) gene and provides allele-specific primers and probes suitable for detecting these allelic variants for applications such as molecular diagnosis, prediction of an individual's disease susceptibility, and/or the genetic analysis of SCA2 gene in a population.

Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.

Abstract: A metabotropic glutamate taste receptor having a molecular weight of approximately 68 kDa, encoded by a cDNA sequence having the mRNA sequence of SEQ ID NO:1 is disclosed, which functions as a umami taste receptor. Also disclosed are cells expressing the cloned receptor and a method of screening for umami mimics using the receptor.

Abstract: A process for the preparation of methylheptanone and corresponding homologous methyl ketones involves the cross-aldolization of acetone with the corresponding aldehyde. The polar catalyst phase is introduced with acetone and an organic auxiliary solvent phase to form a two phase mixture in the presence of hydrogen. The corresponding aldehyde is then added at temperatures between 40° C. and 200° C. The process can be run in a continuous manner with the polar catalyst phase being recyled after regeneration. The use of the non-polar auxiliary solvent(s) increase yield and selectivity.

Abstract: A whmD gene that controls sporulation in mycobacteria, vectors and transformed cells containing the gene.

Abstract: This invention provides processes of the preparation of polyamides, polyimides, and polyamideimides, which are easy to purify after reactions, from polycarboxylic acids and polyamines in high yield without side reactions such as a change of color to black by direct polycondensation reaction with heat, especially processes of preparing aromatic polyamides (aramids), aromatic polyimides, and aromatic polyamideimides, which are difficult to synthesize in direct polycondensation reaction. Polyamides, polymides, and polyamideimides are prepared in high yield by the polycondensation of aromatic dicarboxylic acids, aromatic tetracarboxylic acids or aromatic tricarboxylic acids and aromatic diamines, using arylboric acids such as 3,4,5-trifluorophenylboric acids as polycondensation catalysts, in a mixed solvent of pentamethylbenzene and N-methylpyrrolidinone or a mixed solvent of m-terphenyl and N-butylpyrrolidinone.

Abstract: Racemic &agr;-lipoic acid or its enantiomers or pharmaceutically acceptable salts, esters or amides thereof can be administrated parenterally at a rate of 50 to 600 mg of active compound, based on racemic &agr;-lipoic acid, per minute.

Abstract: The invention relates to novel modifications of the compound 2-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene of the processes for their preparation and their use in pharmaceutical compositions.

Abstract: A device is described which permits the acquisition of Electron Paramagnetic Resonance Images without employing additional hardware for generation of magnetic field gradients. It employs the inherent gradient in the modulation field, operating with high amplitude modulator.

Abstract: An object of the present invention is to provide an ammoxidation reaction catalyst composed of an Sb—Re compound oxide with which ammoxidation into an unsaturated nitrile such as methacrylonitrile or the like can be performed in the presence of a molecular oxygen-containing gas and ammonia, and a method for manufacturing an unsaturated nitrile such as methacrylonitrile or the like from an aliphatic hydrocarbon such as isobutylene, isobutane or the like using this ammoxidation reaction catalyst. An unsaturated nitrile such as methacrylonitrile or the like is manufactured by subjecting an aliphatic hydrocarbon such as isobutylene, isobutane or the like to vapor phase contact ammoxidation with ammonia and a molecular oxygen-containing gas in the presence of an ammoxidation reaction catalyst composed of an Sb—Re compound oxide such as SbRe2O6 or the like.

Abstract: A device is described which permits the acquisition of Electron Paramagnetic Resonance Images without employing additional hardware for generation of magnetic field gradients. It incorporates a module for translation of the bridge-circulator-resonator-detector assembly in order to locate the resonator at an optimal off-center position in the magnet and employs the inherent gradient in the magnetic field, permitting operation with gradients of 5 T m−1 or higher, in continuous wave or pulsed mode.

Abstract: A pharmacological composition including a component having pressure reductive activity obtained from Mycoleptodonoides aitchisonii fruit body which is safe and cheap, harvested constantly year-round by artificial cultivation, with equal quality, and useful for prevention and/or amelioration of symptom of hypertension caused by angiotensin I converting enzyme or the like. The invention also includes foods or beverages containing the pharmacological compositions, and methods of preventing or treating hypertension by administration of the composition.

Abstract: Nordihydroguaiaretic acid derivatives and methods of use thereof for the treatment of tumors.

Abstract: The invention is directed to a DNA probe set, the probe set comprising a first probe set and a second probe set, the first probe set being sufficient in length and substantially complementary to an entire breakpoint region of a first DNA and nucleotides breakpoint region but less than an entire chromosome such that the first probe set will hybridize to both sides of the breakpoint region regardless of whether the first DNA has been broken in the breakpoint region and either end fused to another DNA, and the second probe set being sufficient in length and substantially complementary to an entire breakpoint region of a second DNA and nucleotides on both sides of the breakpoint region but less than an entire chromosome such that the second probe set will hybridize to both sides of the breakpoint region regardless of whether the second DNA has been broken in the breakpoint region and either end fused to another DNA. Diagnostic kits utilizing the probe sets of the invention are also claimed.

Abstract: It has been found that Pyrococcus furiosus produces several starch hydrolyzing enzymes, both extracellularly and intracellularly, which retain their activity for several hours at or above 100° C. These comprise an &agr;-glucosidase, which has been highly purified, and amylolytic enzymes including an amylase and a pullulanase. In addition, at least one thermostable enzyme activity from P. furiosus that is useful in the process of degradation of cellulose to D-glucose has also been found, namely a &bgr;-glucosidase, which is also active up to at least 95° C.

Abstract: Certain antibody molecules are so stable and so potent at immobilizing sperm as well as the pathogens for sexually transmitted diseases (STDs) that they make possible new prophylactic contraceptive methods: (a) for men, a skin lotion containing antibodies against sperm and against STD pathogens to be applied to the penis and external genitals during sexual activity, thereby delivering prophylactically effective doses of antibodies to virtually all areas of skin and epithelia across which most STDs, including AIDS, are usually transmitted, and, during vaginal intercourse, the penis will deliver a contraceptively reliable dose of the antibodies to the cervical region of the vagina; and (b) for women, intrauterine devices (IUDs) and intravaginal devices (IVDS) that release antibodies into the uterus or into the vagina to provide continuous protection against pregnancy and STDs for periods of months to years.