Patents Represented by Attorney, Agent or Law Firm Ann W. Speckman
  • Patent number: 6867035
    Abstract: This invention provides a method for selecting a clone of an ES cell containing a mutation in a gene that is expressed in a test cell comprising: (a) providing cDNA obtained by reverse transcription of mRNA of the test cell; (b) providing a collection of cultured ES cells organized into individual clones, wherein each clone is of an ES cell having a mutation in an exon in its genome, the mutation being in a different exon in cells of different clones; (c) providing an array of different single stranded polynucleotides, the polynucleotides being fragments of exons containing mutations in (b); (d) exposing the cDNA to the array under conditions permitting hybridization of polynucleotides in the array to nucleic acids; (e) detecting hybridization of cDNA to a polynucleotide on the array; and, (f) selecting a clone in the collection from which a hybridizing polynucleotide detected at (c) is an exon fragment. This invention also provides a system for testing expression of a gene in a test cell.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: March 15, 2005
    Assignee: The University of British Columbia
    Inventor: Christopher J. Ong
  • Patent number: 6834238
    Abstract: Optical detection techniques for the assessment of the physiological state, health and/or viability of biological materials are provided. Biological materials which may be examined using such techniques include cells, tissues, organs and subcellular components. The inventive techniques may be employed in high throughput screening of potential diagnostic and/or therapeutic agents.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: December 21, 2004
    Assignee: Cytoscan Sciences LLC
    Inventor: Daryl W. Hochman
  • Patent number: 6833435
    Abstract: Isolated polynucleotides encoding histatin polypeptides expressed in bovine tissues, including mammary gland and paratoid salivary gland tissues, are provided, together with genetic constructs and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: December 21, 2004
    Inventors: Matthew Glenn, Murray R. Grigor, Adrian J. Molenaar, Stephen R. Davis
  • Patent number: 6833446
    Abstract: Novel isolated polynucleotides that encode plant transcription factors are provided, together with DNA constructs comprising such polynucleotides. Methods for using such constructs in modulating the expression of endogenous and/or heterologous genes are also disclosed, together with transgenic plants comprising such constructs.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: December 21, 2004
    Assignees: Agrigenesis Biosciences Limited, Rubicon Forest Holdings Limited
    Inventors: Marion Wood, Michael A. Shenk, Annette McGrath, Matthew Glenn
  • Patent number: 6818001
    Abstract: The intralumenal material removal system includes a cutter assembly positionable in the lumen of a mammalian subject and operably connected to system controls. The cutter assembly is axially advanceable by translating the drive shaft and rotatable by rotating the drive shaft. One cutter assembly comprises an adjustable cutter that is adjustable between a smaller diameter condition and a larger diameter condition by rotation of the drive shaft in opposite directions. The cutter may thus be introduced to and withdrawn from the material removal site in a retracted, smaller diameter condition that facilitates translation and navigation of the device through various lumens. The adjustable cutting assembly may be selectively expanded at the material removal site to facilitate cutting, removal and aspiration of the occlusive material. One composite cutter assembly comprises both a distal, fixed diameter cutter and a proximal adjustable diameter cutter.
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: November 16, 2004
    Assignee: Pathway Medical Technologies, Inc.
    Inventors: Edward I. Wulfman, Thomas J. Clement, Craig E. Lawson, David C. Auth
  • Patent number: 6797271
    Abstract: Isolated polynucleotides and polypeptides derived from mammalian fsn -/-lymph node stromal cells are provided, together with expression vectors and host cells comprising such isolated polynucleotides. Methods for the use of such polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: September 28, 2004
    Assignee: Genesis Research & Development Corporation Limited
    Inventors: Matthew Sleeman, Nevin Abernethy, James Greg Murison
  • Patent number: 6779964
    Abstract: The present invention relates generally to systems and methods for facilitating the movement of fluids, transferring mechanical power to fluid mediums, as well as deriving power from moving fluids. The present invention employs an impeller system in a variety of applications involving the displacement of fluids, including for example, any conventional pumps, fans, compressors, generators, circulators, blowers, generators, turbines, transmissions, various hydraulic and pneumatic systems, and the like.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 24, 2004
    Inventor: Daniel Christopher Dial
  • Patent number: 6768041
    Abstract: Novel isolated polynucleotides that encode polypeptides involved in plant cell signaling are provided, together with genetic constructs comprising such polynucleotides. Methods for using such constructs for the modulation of cell signaling in plants are also disclosed, together with transgenic plants comprising such constructs.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: July 27, 2004
    Assignee: Genesis Research and Development Corporation Limited
    Inventors: Timothy Strabala, Nicolaas Nieuwenhuizen
  • Patent number: 6757392
    Abstract: An electronic stethoscope comprises a headpiece, a chest-piece and two earpieces. The headpiece is fitted with a display arrangement in the form of a liquid-crystal display. A microphone, one or more sensors and fixed electrodes and movable electrodes are mounted in the headpiece. The movable electrodes are fixed to pivoted arms which form a contact ring.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: June 29, 2004
    Inventors: Artemio Granzotto, Fridolin Voegeli
  • Patent number: 6743575
    Abstract: The present invention provides solutions and methods for preserving living biological materials that enable organs, tissues and cells to be stored for extended periods of time with minimal loss of biological activity. The inventive solutions are substantially isotonic with the biological material to be preserved and are substantially free of dihydrogen phosphate, bicarbonate, nitrate, bisulfate and iodide. In one embodiment, preferred for the preservation of platelets, the solutions comprise betaine, sodium chloride and sodium citrate. For the preservation of many living biological materials, the inventive solutions preferably contain a calcium salt selected from the group consisting of calcium sulfate and calcium chloride.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: June 1, 2004
    Assignee: Biostore New Zealand Ltd.
    Inventors: Phillipa M. Wiggins, Alexander B. Ferguson, James D. Watson
  • Patent number: 6735551
    Abstract: The present invention relates to a Mobile Tele-Medical Maintenance system (MTMM system) that applies different IT methods to perform different functions for the tele-medical maintenance of large numbers of individuals. The MTMM system includes a system kernel residing on web servers, linked to a large number of peripheral units on the individuals. The kernel contains a collection of all the “Private Medical Web Sites” and “Personal Health Plans” of the individuals. The MTMM system periphery includes walk-in care offices and intelligent physiological sensors that can communicate directly with the kernel's programs via the Internet or similar communication networks, preferably using the user's phone and its traditional interfaces, message display plus message voice, and push-button plus voice input. The system kernel controls the actuators directly in the periphery and uses message display and message voice output of the telephone to interact with the individual.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: May 11, 2004
    Inventors: Fridolin Voegeli, Fredrick J. Mindermann
  • Patent number: 6723327
    Abstract: Methods for the prevention and treatment of disorders, including disorders of the skin and respiratory system, such as infection with mycobacteria such as M. tuberculosis or M. avium, sarcoidosis, asthma, allergic rhinitis, allergic dermatitis and lung cancers are provided, such methods comprising administering a composition comprising at least one derivative of delipidated and deglycolipidated M. vaccae cells.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: April 20, 2004
    Assignee: Genesis Research and Development Corporation
    Inventors: James D. Watson, Paul L. J. Tan, Ross Prestidge, Nevin Abernethy
  • Patent number: 6716430
    Abstract: Polypeptides and polynucleotides isolated from Mycobacterium vaccae are provided, together with compositions comprising such polypeptide and polynucleotides, and methods for their use in the enhancement of immune responses to heterologous antigens.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: April 6, 2004
    Assignee: Genesis Research and Development Corporation Limited
    Inventor: Alain Delcayre
  • Patent number: 6694919
    Abstract: A free movement guiding installation is provided, which comprises a number of guide gratings suspended on a motor-drivable profile ring. The guide gratings revolve in the region of a circular longeing path and are each distanced to one another. The intermediate space between two neighboring guide gratings forms a horse guiding region. The profile ring is movably held on supports over the circular longeing path by way of a suspension which comprises a frame element with support wheels for the profile ring.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: February 24, 2004
    Inventor: Theo Häring
  • Patent number: 6676319
    Abstract: In the outer sleeve there runs a threaded spindle which is mounted in a bearing sleeve (5) and on which a piston (30) is movable up and down. The outer sleeve (1) is in relation to its inner diameter Ad considerably longer than with known glue sticks. The ratio of the inner diameter Ad of the outer sleeve (1) to the length AL of the part of the outer sleeve which serves for receiving a rod-like adhesive mass (10) here lies in the region of 1:6 to 1:15. This however according to the invention demands that the threaded spindle is configured such that it simultaneously serves as a conveyor worm. Thanks to the special configuration of the piston (30) is spite of the great length of the threaded spindle there is achieved a bending-breakage stabilization.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: January 13, 2004
    Assignee: Uhu GmbH & Co, KG
    Inventors: Wilhelm Werhahn, Werner Panter, Hans-Martin Kapsa
  • Patent number: 6671540
    Abstract: The present invention provides methods and systems for determining the presence and location of abnormal or pathological tissue, for identifying and mapping the margins of abnormal tissue, such as tumor tissue during surgical or diagnostic procedures, and for grading and characterizing tumor tissue by detecting changes in the optical properties of spatially defined areas of an area of interest following administration of a contrast enhancing agent.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: December 30, 2003
    Inventor: Daryl W. Hochman
  • Patent number: 6659322
    Abstract: The invention relates to a tape dispenser for producing lengths of tape. The tape dispenser comprises a rotatable roller on which the tape is wound up and a rotatable take-off roller across which the tape to be taken off is guided. The take-off roller has at least one perforation element that is directed against the surface of support of the tape and that is used to perforate the tape. The dispenser is further provided with latch elements that block the take-off roller if the tape has covered a certain distance once it has been perforated. The latch elements release the take-off roller once the perforated section at the tape's end is separated from the tape.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: December 9, 2003
    Assignee: Kel Development B.V.
    Inventors: Eelco H. De Man, Erwin Boes
  • Patent number: 6638360
    Abstract: Methods for the separation of chaotropic and kosmotropic enantiomers within a racemic mixture are provided. Such methods comprise differentially partitioning the enantiomers into stabilized microdomains of low density water and high density water abutting a porous surface.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: October 28, 2003
    Assignee: Biostore New Zealand Limited
    Inventor: Phillipa M. Wiggins
  • Patent number: 6634864
    Abstract: A capillary pump is provided for producing pressurized vapor emissions, having various layers that assist in creating optimal conditions to accomplish a high maximum fluid flow rate and pressurization. Heat and liquid/vapor flows in opposing directions in pathways within the layers. The pump includes a vaporization layer having small-sized pores and with a thickness and area to reduce viscous drag of flowing liquid and vapor. An ejection layer is also included having one or more openings and an integrated heat transfer portion for conveying heat and providing a low fluidic drag area. The pump may include an insulation layer to shield the liquid in a supply area from heat and/or a preheat layer to raise the temperature of the liquid prior to the liquid entering the vaporization layer. A coating at least partially surrounds the outer surfaces of the pump to allow vapor pressure to increase.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: October 21, 2003
    Assignee: Vapore, Inc.
    Inventors: Thomas M. Young, Mark Richardson, Robert A. Lerner
  • Patent number: D493282
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: July 27, 2004
    Assignee: Georg Utz Holding, AG
    Inventors: Jean-Marc Dubois, Boris Schwab