Patents Represented by Attorney, Agent or Law Firm Anne Dollard
  • Eukaryotic signal sequences for polypeptide expression and polypeptide display libraries
    Patent number: 7396661
    Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.
    Type: Grant
    Filed: February 13, 2003
    Date of Patent: July 8, 2008
    Assignee: XOMA Technology Ltd.
    Inventors: Jeff Gray, Joe Buechler, Uday Kumar Veeramallu
  • Modulation of pericyte proliferation
    Patent number: 7291451
    Abstract: Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: November 6, 2007
    Assignee: XOMA Technology Ltd.
    Inventors: George L. King, Susan Abrahamson, Michael Pugsley
  • Methods and materials for increasing expression of recombinant polypeptides
    Patent number: 7192737
    Abstract: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription unit encoding a polypeptide of interest separated by at least one selective marker gene and methods for sequentially transforming or transfecting host cells with expression vectors to increase transcription unit dosage and expression.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: March 20, 2007
    Assignee: XOMA Technology Ltd.
    Inventor: Arnold H. Horwitz
  • Therapeutic uses of BPI protein products in BPI-deficient humans
    Patent number: 7041644
    Abstract: New therapeutic uses for BPI protein products that involve treatment of subjects with a BPI deficiency condition, including selective BPI deficiency, and newborns, including BPI-deficient newborns.
    Type: Grant
    Filed: April 23, 2002
    Date of Patent: May 9, 2006
    Assignee: XOMA Technology
    Inventor: Ofer Levy
  • Compositions and methods for cancer immunotherapy
    Patent number: 6310045
    Abstract: The present invention provides methods for inhibiting the growth of selected tumors utilizing recombinant viral vectors. Briefly, within one aspect of the present invention, a method for inhibiting the growth of a selected tumor is provided comprising the step of directly administering to a warm-blooded animal a vector construct which directs the expression of at least one anti-tumor agent, such that the growth of said tumor is inhibited. Representative examples of anti-tumor agents include immune activators and tumor proliferation inhibitors.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 30, 2001
    Assignee: Chiron Corporation
    Inventors: Jack R. Barber, Douglas J. Jolly, James G. Respess
  • Method for treating brain cancer with a conditionally lethal gene
    Patent number: 6241982
    Abstract: The present invention provides recombinant viral vectors carrying a vector construct which directs the expression of a gene product (e.g., HSVTK) that activates a compound with little or no cytotoxicity into a toxic product. Also provided are methods of destroying or inhibiting pathogenic agents in a warm blooded animal, comprising the step of administering to the animal a viral vector such as that described above, in order to inhibit or destroy the pathogenic agent.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 5, 2001
    Assignee: Chiron Corporation
    Inventors: Jack R. Barber, Harry E. Gruber, Douglas J. Jolly