Abstract: A chewable tooth cleaning composition which removes dental plaque from the chewing surfaces of the teeth has incorporated into a chewing gum formulation about 20% to about 40% by weight, based on the weight of the total composition, of a calcium carbonate abrasive having a specific particle size distribution.

Abstract: This disclosure relates to a low-moisture, sugarless, center-filled chewing gum and a process for the preparation thereof, in which a low moisture, liquid center-fill is incorporated into a cavity within a substantially anhydrous chewing gum shell. The center-filled chewing gum disclosed has improved non-staling properties and an extended shelf-life. The liquid center-fill has a water content of about 6% to about 8%, based on the total weight of the liquid center-fill, a viscosity of about 22,000 to about 85,000 centipoises at 25.degree. C., and contains a natural or synthetic gum, a glycerin humectant and an additonal, water-miscible humectant.

Abstract: An ingestible, high-density compressed-tablet fiber-composition having a high dietary fiber content is prepared by blending at least one high fiber source with a microcrystalline cellulose compression aid; mixing water with the blend at a rate ratio of about 1.5:1 to about 2.5:1 based on the weight of water to the weight of the blend, for a time sufficient to form a cohesive, deformable, plastic mass; drying the plastic mass and milling the dried product to recover granules having a particle size of about 125 to about 840 microns; blending the granules with a tableting lubricant and compressing into a high-density, high fiber tablet.

Abstract: A high dietary fiber-containing snack food product and process for making the same is disclosed. The product comprises from about 5 to about 30% by weight of dietary fiber, soaked in a food grade oil, for example, admixed with peanut butter such that the peanut oil becomes absorbed by the fiber, and further mixed with a compound coating. The compound coating serves as a binder and processing aid for extrusion of the mixture into shapes for immediate consumption. No baking, cooking, toasting or the like is necessary.

Abstract: This invention relates to novel compounds having the formula I: ##STR1## wherein R is hydrogen, lower alkyl, lower alkoxy or halogen; R' is amino lower alkyl wherein the amino group is unsubstituted or substituted by mono- or di(lower alkyl); and X is S or SO.sub.2 ; and the non-toxic, pharmaceutically acceptable salts thereof, which are useful as antidepressants. Intermediates having the formula IV, which are used in the preparation of the compounds having the formula I are also disclosed: ##STR2## wherein R is hydrogen, lower alkyl, lower alkoxy or halogen; and X is S or SO.sub.2.

Abstract: The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents.

Abstract: This invention relates to novel amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide having the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; Ar is aryl or heterocyclic; to the pharmaceutically acceptable salts thereof; and to processes for their preparation. The compounds of this invention exhibit antiinflammatory activity.

Abstract: This invention relates to 5,6-dihydro-4-oxo-4H-thieno[2,3-b]thiopyran-5-carboxamides of the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; and Ar is aryl or heterocyclic; their pharmaceutically acceptable salts and to processes for their preparation. The compounds of this invention exhibit antibacterial, antifungal and antiallergy activity.

Abstract: 1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenoxy-1,2,3,6-tetrahydropyridines and related piperidines are disclosed in the present invention. These compounds have the structural formulas: ##STR1## in which X is hydrogen, halogen, dihalogen, trifluoromethyl, lower alkoxy, nitro, amino, cyano, lower alkyl, aryl or substituted aryl. Also included are the corresponding non-toxic, pharmaceutically acceptable acid addition salts, and the N-oxides of compounds of the formulas I and II.The above compounds are useful in the management of manifestations of psychotic disorders.

Abstract: This invention relates to 5,6-dihydro-4-oxo-4H-theino[2,3-b]thiopyran-5-carboxamides of the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; and Ar is aryl or heterocyclic; their pharmaceutically acceptable salts and to processes for their preparation. The compounds of this invention exhibit antibacterial, antifungal and antiallergy activity.

Abstract: Diphenylbutyltetrahydropyridines of the following formula: ##STR1## are disclosed, in which X is hydrogen, halogen such as fluorine, chlorine or bromine, trifluoromethyl, alkoxy, nitro, amino, lower alkyl of 1 to 6 carbon atoms, aryl or substituted aryl and n is 0, 1 or 2. These compounds are useful as antipsychotics.

Abstract: This invention relates to novel amides of 4-hydroxy-6H-thieno[2,3-b]thiopyran-5-carboxylic acid-7,7-dioxide having the Formula I: ##STR1## wherein R.sub.1 is hydrogen, halogen or lower alkyl; R.sub.2 is hydrogen, lower alkyl or aryl; Ar is aryl or heterocyclic; to the pharmaceutically acceptable salts thereof; and to processes for their preparation. The compounds of this invention exhibit antiinflammatory activity.

Abstract: Compounds of formula I: ##STR1## wherein Y is hydrogen, lower alkyl, halogen or lower alkoxy; X is carboxy, alkoxycarbonyl, carboxamide, cyano or tetrazolo, and their non-toxic, pharmaceutically acceptable salts are disclosed. These compounds are useful in the prevention of allergic and asthmatic reactions.

Abstract: The present invention relates to dialkyl ({[3-(alkoxy-carbonyl)-1,4-dihydro-4-oxo-8-quinolinyl]amino}methylene)-pro panedioates having the following structural formula: ##STR1## wherein R.sub.1 is lower alkyl; and R.sub.2 is hydrogen, halogen, lower alkyl or nitro.These compounds exhibit antibacterial activity against gram positive and gram negative bacteria and are therefore useful in the treatment of bacterial infections caused by these organisms.

Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, halogen, hydroxy or lower alkoxy; R.sub.2 is hydrogen or lower alkyl; R.sub.3 is hydrogen or lower alkyl; and the pharmaceutically acceptable, non-toxic salts thereof. The compounds of the invention are active in the prevention of allergic and asthmatic reactions in mammals.

Abstract: A novel process for preparing 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides is disclosed. The process involves the base catalyzed rearrangement of a saccharinacetamide of structure I to give II, ##STR1## wherein R.sup.1 is hydrogen or lower alkyl and R.sup.2 is lower alkyl, aryl or a heterocyclic ring selected from the group consisting of pyridyl, substituted-pyridyl, and thiazolyl. Compounds of the formula II have useful anti-inflammatory properties. In addition, they can be used as intermediates in the preparation of known anti-inflammatory agents.

Abstract: The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents.

Abstract: 1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

Abstract: The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents.

Abstract: Compounds having the following structural formula are disclosed: ##STR1## wherein R.sub.1 is hydrogen or methyl and R.sub.2, and R.sub.3 are hydrogen or alkyl. These compounds are useful as anti-inflammatory agents, antipyretics, analgesics.