Patents Represented by Attorney, Agent or Law Firm Anne M. Rosenblum
  • Therapeutically active 3-amino-1-halogenated phenyl-2-pyrazolines and their C4 and C5 analogs
    Patent number: 4451479
    Abstract: A method of meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, treating pain or treating bacterial and fungal infections in mammals using 3-amino-1-halogenated phenyl-2-pyrazolines and their C4 and C5 analogs.
    Type: Grant
    Filed: October 4, 1982
    Date of Patent: May 29, 1984
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Joseph P. Joseph, Seymour Bernstein
  • Therapeutically active 3-substituted amino-1-phenyl and substituted phenyl-2-pyrazolines
    Patent number: 4448973
    Abstract: 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-substituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: May 15, 1984
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Joseph P. Joseph, Seymour Bernstein
  • 3-Trifluoroacetylamino-1-aryl-2-pyrazolines
    Patent number: 4447442
    Abstract: This disclosure describes novel 3-substituted amino-1-phenyl-2-pyrazolines and 3-substituted amino-1-mono and disubstituted phenyl-2-pyrazolines and their C.sub.4 and C.sub.5 analogs, useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
    Type: Grant
    Filed: August 9, 1982
    Date of Patent: May 8, 1984
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Joseph P. Joseph, Seymour Berstein
  • Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives
    Patent number: 4440758
    Abstract: Poly-cation salts of bis(or tris)[4-O-monohexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: April 3, 1984
    Assignee: American Cyanamid Company
    Inventors: Janis Upeslacis, Robert E. Schaub, Seymour Bernstein
  • Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives
    Patent number: 4435387
    Abstract: Poly-cation salts of bis (or tris) 4-O-polyhexose-thio-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: March 6, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Therapeutically active 3-amino-1-phenyl(and substituted phenyl)-2-pyrazolines
    Patent number: 4432991
    Abstract: This disclosure describes certain 3-amino-1-phenyl-2-pyrazolines and 3-amino-1-substituted phenyl-2-pyrazolines and their C4 and C5 analogs useful for meliorating the inflammation and/or the progressive joint deterioration characteristic of arthritic disease, preventing the onset of asthmatic symptoms and allergic diseases, or as analgesic, antibacterial or antifungal agents.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: February 21, 1984
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Joseph P. Joseph, Seymour Bernstein
  • Polycation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives
    Patent number: 4431637
    Abstract: Poly-cation salts of bis (or tris) [4-O-polyhexose-oxy]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Janis Upeslacis, Robert E. Schaub, Seymour Bernstein
  • Poly-cation salts of bis(or tris)[4-0-monohexose-thio]-arylene sulfate derivatives
    Patent number: 4431638
    Abstract: Poly-cation salts of bis(or tris)[4-O-monohexose-thio]-arylene sulfate derivatives useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
    Patent number: 4431636
    Abstract: Poly-cation salts of bis (4-O-polyhexaose-thio)-phenyl urea sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: February 14, 1984
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Rutin poly(H-)sulfate salts and related compounds
    Patent number: 4414207
    Abstract: Rutin poly(H-)sulfate and salts thereof useful as complement inhibitors.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: November 8, 1983
    Assignee: American Cyanamid Company
    Inventors: Vijay G. Nair, Seymour Bernstein
  • Modulators of the complement system
    Patent number: 4407796
    Abstract: Poly-cation salts of bis-(or tris-) [polyhexaose-thio (or sulfinyl, or sulfonyl)]-arylene sulfate derivatives, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: October 4, 1983
    Assignee: American Cyanamid Company
    Inventors: Thomas G. Miner, Seymour Bernstein
  • Poly cation salts of monohexosethio (or oxy) alkyl diamides
    Patent number: 4404195
    Abstract: N,N'-Bis[4-[(2,3,4,6-tetra-O-sulfo-.alpha.(or .beta.)-D-glucopyranosyl)thio(or oxy)]phenyl]alkyl diamides, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: September 13, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Modulators of the complement system
    Patent number: 4404365
    Abstract: Bis-[.beta.-D-glucopyranosyl-1-thio (or sulfinyl or sulfonyl)]-arylene sulfate derivatives, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process for the preparation of such intermediates and end products.
    Type: Grant
    Filed: December 28, 1981
    Date of Patent: September 13, 1983
    Assignee: American Cyanamid Company
    Inventors: Thomas G. Miner, Seymour Bernstein
  • Polysulfonate Sennoside A & B compounds and method of use
    Patent number: 4402944
    Abstract: Polysulfonated Sennoside A and B derivatives, useful as complement inhibitors and the process of making such compounds.
    Type: Grant
    Filed: June 1, 1982
    Date of Patent: September 6, 1983
    Assignee: American Cyanamid Company
    Inventors: Francis M. Callahan, Seymour Bernstein
  • N,N'-Bis(glucopyranosyl-D-glucopyranosyloxyphenyl)alkaline and methods of use
    Patent number: 4401661
    Abstract: N,N'-Bis[4-[2,3,6-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosyloxy]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 30, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Modulators of the complement system
    Patent number: 4399126
    Abstract: N,N'-Bis[4-[2,3,6,-tri-O-sulfo-4-O-(2,3,4,6-tetra-O-sulfo-.alpha.(and .beta.)-D-glucopyranosyl)-.alpha.(and .beta.)-D-glucopyranosylthio or sulfinyl or sulfonyl]phenyl]alkyldiamides and alkyldiamines, the cation salts thereof, useful as modulators of the complement system, the intermediates thereof and the process of making such intermediates and end products.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: August 16, 1983
    Assignee: American Cyanamid Company
    Inventors: Robert E. Schaub, Janis Upeslacis, Seymour Bernstein
  • Substituted phenyl-5-aminopyrazoles
    Patent number: 4393217
    Abstract: This disclosure describes novel substituted phenyl-5-aminopyrazoles useful as anxiolytic and/or anti-depressant agents.
    Type: Grant
    Filed: January 12, 1981
    Date of Patent: July 12, 1983
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Jay D. Albright
  • Ureylenebis (hydroxy naphthalenesulfonic acids)
    Patent number: 4391824
    Abstract: Methods of use and compositions of matter of certain ureides of substituted naphthalenesulfonic acids and salts thereof, useful as inhibitors of connective tissue destruction.
    Type: Grant
    Filed: July 27, 1981
    Date of Patent: July 5, 1983
    Assignee: American Cyanamid Company
    Inventors: Gerald J. Siuta, Seymour Bernstein
  • Ureylenebis substituted (or unsubstituted) phenylene-carbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalene-trisulfonic acids and salts
    Patent number: 4387059
    Abstract: Ureylenebis substituted (or unsubstituted) phenylenecarbonyl (or sulfonyl)-imino-1,3,5 or 6-naphthalenetrisulfonic acids and salts thereof, useful as complement inhibitors, the intermediates thereof, and the process of making such intermediates and end products.
    Type: Grant
    Filed: November 25, 1981
    Date of Patent: June 7, 1983
    Assignee: American Cyanamid Company
    Inventors: Ransom B. Conrow, John F. Poletto, Seymour Bernstein
  • Process for producing the antibiotic nosiheptide
    Patent number: 4384043
    Abstract: This disclosure describes a novel process for the production of the known antibiotic nosiheptide using a new strain of Streptomyces glaucogriseus and mutants thereof.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: May 17, 1983
    Assignee: American Cyanamid Company
    Inventors: John H. E. J. Martin, David P. Labeda, Joseph D. Korshalla, Donald B. Borders, Raymond T. Testa