Patents Represented by Attorney, Agent or Law Firm Arnold S. Milowsky
  • 6-Hydroxyequilenins as estrogenic agents
    Patent number: 7235539
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; X is R2 is hydrogen, alkyl of 1–6 carbon atoms, benzyl, alkylcarbonyl of 2–7 carbon atoms, or benzoyl; R3 is hydrogen, alkyl of 1–6 carbon atoms, hydroxy, or alkoxy of 1–6 carbon atoms; a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of a sulfate ester of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen, or a glucuronide of the hydroxyl group at the 3- or 17-position when R1 or R2 is hydrogen.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: June 26, 2007
    Assignee: Wyeth
    Inventors: Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Galina Vid, Sreenivasulu Megati, Christopher P. Miller
  • Substituted benzoxazoles as estrogenic agents
    Patent number: 7148247
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: December 12, 2006
    Assignee: Wyeth
    Inventors: Michael S Malamas, Robert E McDevitt, Iwan Gunawan, Eric S Manas, Michael D Collini, Heather A Harris, James C Keith, Jr., Leo M Albert, Cecil Richard Lyttle
  • Substituted benzoxazoles as estrogenic agents
    Patent number: 7129258
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: October 31, 2006
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini
  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 7067524
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 18, 2004
    Date of Patent: June 27, 2006
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Method of treating hepatic fibrosis
    Patent number: 7060709
    Abstract: This invention provides the use of rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid (CCI-779) in the treatment or inhibition of hepatic fibrosis and hepatic cirrhosis.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: June 13, 2006
    Assignee: Wyeth
    Inventors: Brenda Cooperstone, Robert Clare, George Stanley
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Patent number: 7022733
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R?, A, A?, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: April 4, 2006
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
  • Preparation of 6-hydroxyequilenins
    Patent number: 6956126
    Abstract: This invention relates to a process for the preparation of 6-hydroxyequilenins, which are useful as estrogenic agents.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: October 18, 2005
    Assignee: Wyeth
    Inventors: Sreenivasulu Megati, Galina Vid, Arthur Mohan, Panolil Raveendranath, John Potoski
  • Substituted phenyl naphthalenes as estrogenic agents
    Patent number: 6914074
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: July 5, 2005
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Cuijian Yang, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Eric S. Manas
  • Substituted indenones as estrogenic agents
    Patent number: 6903238
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: June 7, 2005
    Assignee: Wyeth
    Inventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • 2-phenyl-1-[4(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
    Patent number: 6835729
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in lowering cholesterol levels.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: December 28, 2004
    Assignee: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Phenyl substituted thiophenes as estrogenic agents
    Patent number: 6835745
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein, R1, R2, R3, X, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: December 28, 2004
    Assignee: Wyeth
    Inventors: Richard D. Coghlan, William F. Fobare, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • B-ring estratrienes
    Patent number: 6818636
    Abstract: This invention provides 3&bgr;-hydroxy-5,7,9-estratriene-17-one and a pharmaceutically acceptable salt of its 3-sulfate ester, which is useful as an estrogen.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: November 16, 2004
    Assignee: Wyeth
    Inventors: Syed M. Shah, Panolil Raveendranath, Michael Z. Kagan
  • Substituted benzoxazoles as estrogenic agents
    Patent number: 6794403
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R2a, R3, R3a, and R4, and X as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: September 21, 2004
    Assignee: Wyeth
    Inventors: Michael S. Malamas, Robert E. McDevitt, Iwan Gunawan, Eric S. Manas, Michael D. Collini
  • 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
    Patent number: 6787538
    Abstract: The present invention relates to new 2-Phenyl-1-[4-(2-Aminoethoxy)-Benzyl]-Indole compounds having the general structures below: which are useful in providing hormone replacement therapy.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: September 7, 2004
    Assignee: Wyeth
    Inventors: Chris P. Miller, Michael D. Collini, Bach D. Tran, Arthur A. Santilli
  • Substituted 2-phenyl benzofurans as estrogenic agents
    Patent number: 6774248
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R, R′, A, A′, X, Y, and Y are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 16, 2002
    Date of Patent: August 10, 2004
    Assignee: Wyeth
    Inventors: Christopher P. Miller, Michael D. Collini, David H. Kaufman, Robert L. Morris, Robert R. Singhaus, Jr., John W. Ullrich, Heather A. Harris, James C. Keith, Jr., Leo M. Albert, Rayomand J. Unwalla
  • N-(4-sulfonylaryl)cyclylamine-2-hydroxyethylamines as beta-3 adrenergic receptor agonists
    Patent number: 6743787
    Abstract: This invention provides compounds of Formula I having the structure wherein R1, R2, R3, R4, W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Wyeth
    Inventors: Fuk-Wah Sum, Michael Sotirios Malamas
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Patent number: 6723747
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 20, 2004
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Pregnanes
    Patent number: 6713465
    Abstract: This invention provides a pharmaceutically acceptable salt of 5&agr;-pregn-16-en-3&bgr;-ol-20-one 3-sulfate ester, which is useful as a progestational agent.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: March 30, 2004
    Assignee: Wyeth
    Inventors: Reinhold H. W. Bender, Mahdi B. Fawzi, Horace Fletcher, III, George O. Morton, Syed M. Shah, Xuejun Tang
  • B-ring estratriene diols
    Patent number: 6693207
    Abstract: This invention provides estrogenic agents having the formula wherein A and B are each, independently, R is SO3−X+; X+ is alkali metal, alkaline earth metal, ammonium, alkylammonium containing 1-6 carbon atoms, or dialkylammonium containing 1-6 carbon atoms in each alkyl group, or trialkylammonium containing 1-6 carbon atoms in each alkyl group; with the proviso that at least one of A or B is
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: February 17, 2004
    Assignee: Wyeth
    Inventors: Michael Z. Kagan, Panolil Raveendranath, Syed M. Shah, Michael W. Winkley
  • Method of treating cardiovascular disease
    Patent number: 6670355
    Abstract: This invention provides a method of treating or inhibiting cardiovascular, cerebral vascular, or peripheral vascular disease in a mammal in need thereof, which comprises providing said mammal with an effective amount of a rapamycin.
    Type: Grant
    Filed: December 6, 2002
    Date of Patent: December 30, 2003
    Assignee: Wyeth
    Inventors: Neal I. Azrolan, Steven J. Adelman, Surendra N. Sehgal