Abstract: Cyanoguanidine quinazoline and cyanoamidine quinazolamine derivatives that are useful in the treatment of hyperproliferative diseases are disclosed. Methods of treating hyperproliferative diseases in mammals are also disclosed.
Type:
Grant
Filed:
September 12, 2008
Date of Patent:
January 3, 2012
Assignee:
Array BioPharma Inc.
Inventors:
Eli Wallace, George Topolov, Qian Zhao, Joseph P. Lyssikatos
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
Type:
Grant
Filed:
March 6, 2008
Date of Patent:
June 7, 2011
Assignee:
Array BioPharma Inc.
Inventors:
Jeremy Hans, Eli M. Wallace, Qian Zhao, Joseph P. Lyssikatos, Thomas D. Aicher, Ellen R Laird, John Robinson, Shelley Allen