Abstract: A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.

Abstract: A dermal substance collection device (DSCD) is described which provides means for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.

Abstract: This invention relates to novel 2-acetyl- and 2-propionylpyridine selenosemicarbazones. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the selenosemicarbazones.

Abstract: The subject 8-[6-(N-heterocyclic-substituted)hexylamino]-6-methoxy lepidine erivatives have the formula: ##STR1## wherein Z represents methyl or, together with the two contiguous carbon atoms, the benzo moiety of a benzopiperazinyl derivative when Y is --N(R')--, n is an integer from 0 to 2; Y represents --O--, --S--, --S(O)--, --S(O).sub.2 --, and --N(R')--; R' represents hydrogen, alkyl, lower alkyl, R" substituted lower alkyl, cycloalkyl, aryl, sulfonyl, saturated 1,4-diazepinyl, lower alkyl N-cyanocarboximidothioate, or --C(O)R'"; R" represents at least one of hydroxy, alkoxy, aralkoxy, amino, lower alkyl substituted amino, phenyl, halogenated phenyl, or sufonyl; and R'" represents lower alkyl, alkoxy, aralkoxy, amino, lower alkyl substituted amino or aryl substituted amino; and pharmaceutically acceptable salts thereof. These derivatives afford improvement in means for the chemotherapy of leishmaniasis when administered parenterally or orally to infected animals.

Abstract: This invention relates to novel transition metal complexes of 2-acetyl- and -propionylpyridine thiosemicarbazones, their selenium analogs. These compounds are useful as antimalarial and antileukemic agents. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones and their selenium analogs.

Abstract: A chemical contamination monitoring system is provided for monitoring and decontaminating protective clothing that has been exposed to toxic chemicals. The system includes a decontamination chamber in which the clothing is supported and a spray assembly, including a plurality of suitably directed spray nozzles, for spraying the clothing with a wash-solvent. Hot air is directed over the clothing to volitalize the contaminates and, after passing over the clothing, the hot air is withdrawn for analysis using gas chromatography or other known techniques. The used solvent can also be analyzed.

Abstract: A novel bone repair material consisting essential of decalcified freeze-dd bone and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The bone repair material was prepared by combining decalcified bone with a copolymer consisting essentially of a 50:50 poly(L)(-)lactide co-glycolide.

Abstract: A sensitive and specific radioimmunoassay is developed for L-hyoscyamine ulting from atropine administration with which a concentration as low as 25 pg/ml using 0.1 ml of sample can be measured without the need for extraction. Specificity studies indicate that an antibody according to this invention has high specific recognition of L-hyoscyamine with only about 37% cross reaction with the D-hyoscyamine enantiomer of atropine. The antibody is produced from an immunogen having conjugated at least 42 and preferably 45 L-hyoscyamine-p-aminobenzoic acid haptenic molecules per molecule of bovine serum albumin. An antibody according to this invention can be used with a dilution titer as high as 1:2000.

Abstract: A novel material consisting of a combination of a proteolipid and biodegradable, biocompatible copolymer has been developed for improving and accelerating the healing of osseous tissue. The proteolipid was prepared by combining muco-peptide-N-acetyl-muramoylhydrolase with phosphatidyl inositol, 4,5-diphosphate and the copolymer consists essentially of a 50:50 poly(L)(-)lactide co-glycolide.

Abstract: A method and apparatus are provided for data compression in a digital facile document transmission system. In accordance with the method, only alternate scan lines are transmitted, i.e., every other line is deleted in transmission, and at the receiver, the missing scan lines are interpolated from the transmitted data. This compression technique provides a fixed compression ratio of 2 to 1 regardless of the complexity of the input document. The interpolation method relies on comparing, for each picture element to be interpolated, the colors of one or more pairs of adjacent picture elements of the transmitted scan lines and making a decision as to the color of the picture element to be interpolated on this basis.

Abstract: This invention is directed to a Wheatstone bridge circuit for measuring pressure in the distal esophageal sphincter (D.E.S.) as well as in other organs and bodily cavities. A flexible hollow tube having three spaced electrodes is lodged in the esophagus. The tube is partly filled with a saline solution to cover the electrodes, thereby producing two series connected, pressure sensitive resistors. The electrolytic resistors are coupled to two series connected fixed resistors to complete the bridge circuit. Electrical imbalances in the bridge circuit are measured in terms of the pressure corresponding to the pressure applied by the D.E.S.

Abstract: This disclosure concerns a communications network information system, and ovides apparatus and a method for efficiently providing survivable communications capability to every surviving node in the communications network from every other surviving node. The types of information provided can include high priority message between users of the communications system, or perhaps of even greater importance, very frequently updated status information about the communications network nodes and their interconnecting links for use in optimally utilizing the surviving resources of a heavily damaged network. With this capability every surviving node in the network will be automatically and efficiently provided with the status of every node and interconnecting link.

Abstract: A typical embodiment of the invention provides a means for protecting delte instruments from damage. A flexible membrane separates two chambers in which, during ordinary operation, the fluid pressures are the same. One of the two chambers also serves as a fluid conduit in the system. Pressure loss in the system causes the higher pressure chamber to flex the membrane which closes a port in the fluid conduit chamber, thereby preventing further system pressure loss and consequent equipment damage. The membrane, moreover, can have a small bleed to permit gradual, dampened fluid pressure release.

Abstract: An apparatus for measuring the strength of a bond between a lamina and its ubstrate, or the like is shown and described. Air, or some other fluid under pressure, causes a gasket to protrude from a piston to seal the atmosphere from a chamber within the piston and the adjacent exposed lamina surface. The fluid also pressurizes this chamber to pull a loading fixture and a portion of the lamina attached thereto away from the substrate. The force required to pull the lamina from the substrate is equal to the strength of the bond.

Abstract: A tomographic marking device is disposed in an electron microscope between a goniometer stage for holding a specimen and a fluorescent screen for displaying a magnified image of the specimen. The device comprises an externally geared, ring wheel, having a pair of spaced-apart, colinearly disposed pins fixed to the inner periphery of the wheel and defining a straight line parallel to both the screen and the tilt axis of rotation of the goniometer stage. Because the magnetic lenses of the microscope rotate the magnified image on the screen, means are provided to rotate the wheel and to indicate the position of angular rotation of the tilt axis of the goniometer stage located on the screen relative to the actual tilt axis of the goniometer stage.

Abstract: This invention relates to molecular modification of hemoglobin by utilizan of a class of .alpha., .omega.-dialdelhydes having a chain length of 5 to 7 members and substituted with at least one negatively charged group such as a phosphate moiety. A subject .alpha., .omega.-dialdehyde can be synthesized by sodium periodate oxidation of a phosphorylated ribose such as adenosine-5'-triphosphate or 5-phosphoribosyl-1-pyrophosphate. The compounds of this invention can be advantageously used for intramolecularly crosslinking hemoglobin for resuscitative purposes.

Abstract: Unconfined detonation by a single-event process is achieved by simultaneous ispersion of both fuel and the initiating chemical catalyst into the atmosphere. The fuel is selected from a volatile liquid (lower molecular weight, alkanes, epoxyalkanes, etc.), aluminum, boron, etc. or mixtures thereof. The initiating chemical catalyst is selected from n-hexylcarborane, carboranylmethyl propionate, ferrocene, n-butylferrocene etc. The fuel and initiating chemical catalyst are dispersed simultaneously to form a cloud after the catalyst is premixed with the fuel and housed in a container prior to dispersion. The dispersed catalyst catalyzes the reaction between fuel and atmosphere oxygen to produce the explosive oxidation of the fuel-air mixture.Additional enhancers for detonability such as a bis(difluoroamino) compound (TVOPA) and/or ultrafinely-ground ammonium perchlorate are included in the fuel-catalyst mixture when the unconfined detonation is to be achieved in an oxygen-deficient atmosphere.

Abstract: A retaining device for fixedly holding a surgical instrument in a predetermined spatial orientation during surgery comprising an arm having a ball-and-socket joint for grasping the surgical instrument, another arm having a ball-and-socket joint for securing the device to a stationary base and an intermediate pin joint which connects the arms and acts in conjunction with the ball-and-socket joints to allow placement of the surgical instrument in a desired position. The retaining device further comprised a means at the pin joint for simultaneously tightening all joints of the device after placement of the surgical instrument and thereby fixing the position of the surgical instrument.

Abstract: A portable multi-component reclining examination chair comprises a contai wherein the chair's components can be stored for transportation. When removed from the container, the components attach to the container for assembly of the chair. Assembled, the chair uses the container as a stabilizing base to which are attached leveling legs, an adjustable seat having a reclinable back rest, a head rest, removable arm rests and either a leg rest or a foot rest depending on the particular use of the chair.

Abstract: An instructional polariscope which is easily disassembled, reassembled, cbrated and operated in the classroom by individual students for the purposes of teaching and demonstrating the interoperation of components of a polariscope and the principles of photoelasticity. This polariscope can be assembled for use as either a plane or a circular polariscope and employs a reflector which allows use of an external light source.