Patents Represented by Attorney Arthur R. Whale
  • Patent number: 4632939
    Abstract: This invention provides certain benzamide derivatives of the formula: ##STR1## wherein Z is bond, --CH.sub.2 --, or CHCH.sub.3 ; A is --CH.sub.2 --, or CH.sub.2 CH.sub.2 --; and represents a single or double bond; and their pharmaceutical formulations and their use as anticonvulsant agents.
    Type: Grant
    Filed: March 15, 1985
    Date of Patent: December 30, 1986
    Assignee: Eli Lilly and Company
    Inventors: Edward E. Beedle, David W. Robertson
  • Patent number: 4616078
    Abstract: This specification describes a process for separating impurities from an impure mixture containing proinsulin-like material with substantially complete recovery of said proinsulin-like material, which comprises:(1) applying said mixture to a reverse phase macroporous acrylate ester copolymer resin support at a pH of from about 7 to about 10; and(2) eluting said proinsulin-like material from said support with an aqueous eluant having a pH of from about 8 to about 11 and containing from about 10% to about 30% by volume of an organic diluent selected from the group consisting of acetone, acetonitrile, and a combination of acetone and acetonitrile.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: October 7, 1986
    Assignee: Eli Lilly and Company
    Inventor: Richard D. DiMarchi
  • Patent number: 4614807
    Abstract: 6,7-Dichloromelatonin and related compounds are ovulation inhibitors of the formula ##STR1## wherein R and R.sup.1 are individually F or Cl, R.sup.2 is C.sub.1-3 alkyl, including methyl, ethyl, n-propyl and isopropyl, and R.sup.3 is H or methyl.
    Type: Grant
    Filed: October 4, 1984
    Date of Patent: September 30, 1986
    Assignee: Eli Lilly and Company
    Inventor: Michael E. Flaugh
  • Patent number: 4609645
    Abstract: Macrolides PTL-448 A and B, which can be prepared by aerobic cultivation of Streptomyces ambofaciens ATCC 15154 in the presence of a macrolide intermediate selected from protylonlide, 5-O-mycaminosylprotylonolide, 20-hydroxy-5-O-mycaminosylprotylonolide and 20-oxo-5-O-mycaminosylprotylonodide, and macrolides PTL-448 C and D, which can be prepared by acidic hydrolysis of PTL-448 A and B are useful antibiotics.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: September 2, 1986
    Inventor: Satoshi Omura
  • Patent number: 4609670
    Abstract: Imidazolium salts are effective in lowering blood glucose levels in mammals following administration.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: September 2, 1986
    Assignee: Eli Lilly and Company
    Inventors: Samuel J. Dominianni, Terence T. Yen
  • Patent number: 4604127
    Abstract: This invention describes novel pyridazinylimidazolidinone compounds, which are useful as herbicides.
    Type: Grant
    Filed: May 15, 1985
    Date of Patent: August 5, 1986
    Assignee: Eli Lilly and Company
    Inventors: Riaz F. Abdulla, Jack G. Samaritoni
  • Patent number: 4602044
    Abstract: .beta.-Phenethanolamines are useful as antiobesity agents.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: July 22, 1986
    Assignee: Eli Lilly and Company
    Inventors: Klaus K. Schmiegel, Walter N. Shaw
  • Patent number: 4602025
    Abstract: This invention provides a method of inhibiting aromatase and treating estrogen-dependent diseases in mammals by administering certain azole derivatives. Certain azole derivatives and their pharmaceutical formulations are also provided.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: July 22, 1986
    Assignee: Eli Lilly and Company
    Inventors: Kenneth S. Hirsch, Charles D. Jones, Harold M. Taylor
  • Patent number: 4600430
    Abstract: This invention discloses novel pyridinylimidazolidinone compounds, which are useful as herbicides.
    Type: Grant
    Filed: February 22, 1985
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Riaz F. Abdulla, Jack G. Samaritoni
  • Patent number: 4600773
    Abstract: Crystalline cephalexin hydrochloride ethanol solvate converts to crystalline cephalexin hydrochloride monohydrate upon being exposed to moisture.
    Type: Grant
    Filed: December 1, 1983
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Gary L. Engel, Joseph M. Indelicato, Harry A. Rose
  • Patent number: 4600777
    Abstract: 1-C.sub.1-3 straight chain alkyl 7-oxodecahydroquinoline, chemical intermediates.
    Type: Grant
    Filed: August 2, 1984
    Date of Patent: July 15, 1986
    Assignee: Eli Lilly and Company
    Inventors: Diane L. Huser, John M. Schaus, Robert D. Titus, Leland O. Weigel
  • Patent number: 4599339
    Abstract: Trans-(.+-.)-2-Amino or substituted amino-4-permissibly-substituted 6-lower alkyl or allyl-5,5a,-6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-)-stereoisomers and salts thereof, useful in treating anxiety, Parkinson's Syndrome, sexual dysfunction, depression, hypertension and elevated prolactin levels, and intermediates useful for the synthesis thereof.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: July 8, 1986
    Assignee: Eli Lilly and Company
    Inventors: Cynthia L. Nichols, Edmund C. Kornfeld
  • Patent number: 4596676
    Abstract: Bifunctional ester derivatives at C-4 carbon of dimeric indole-dihydroindole alkaloids; e.g., VLB 4-hemisuccinate.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: June 24, 1986
    Assignee: Lilly Industries Limited
    Inventor: George J. Cullinan
  • Patent number: 4596871
    Abstract: Tautomeric mixtures of trans-(.+-.)-3,5-dialkyloctahydropyrazolo[3,4-g]quinoline, of trans-(.+-.)-6-alkyloctahydropyrazolo[4,3-f]quinoline, and of trans-(.+-.)-1,6-dialkyloctahydropyrazolo[4,3-f]quinoline, individual enantiomer thereof, pharmaceutically-acceptable acid addition salts thereof, and intermediates useful in the preparation thereof, useful as hypotensive agents.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: June 24, 1986
    Assignee: Eli Lilly and Company
    Inventors: John M. Schaus, Diane L. Huser, Richard N. Booher
  • Patent number: 4596827
    Abstract: The present invention relates to a new class of alkylsulfonamidophenylalkylamines which are potent antiarrhythmic agents having good oral bioavailability properties.
    Type: Grant
    Filed: November 7, 1985
    Date of Patent: June 24, 1986
    Assignee: Eli Lilly and Company
    Inventors: Bryan B. Molloy, Mitchell I. Steinberg
  • Patent number: 4595754
    Abstract: A process for preparing a cis N-alkylperhydroquinoline comprising reacting a 3-chloropropyl N-alkylimine with a hydride reducing agent in a basic reaction medium at a temperature in the range of from about -20.degree. C. to about 25.degree. C.
    Type: Grant
    Filed: March 4, 1985
    Date of Patent: June 17, 1986
    Assignee: Eli Lilly and Company
    Inventors: Randall K. Atkins, Leland O. Weigel
  • Patent number: 4595586
    Abstract: The present invention provides a novel moisturizing lotion which increases the rate of cell renewal on the skin without causing skin irritation and which facilitates the subsequent application of make-up.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: June 17, 1986
    Assignee: Eli Lilly and Company
    Inventor: Merlyn G. Flom
  • Patent number: D284411
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: June 24, 1986
    Assignee: Eli Lilly and Company
    Inventor: John E. Taylor, Jr.
  • Patent number: RE32196
    Abstract: Substituted aurones of formula (I): ##STR1## wherein R.sup.1, R.sup.2 R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or different and can each represent hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.3-8 cycloalkyl, optionally substituted phenyl, C.sub.1-6 haloalkyl, amido, amino, cyano, hydroxy, nitro, C.sub.2-4 alkenyl, carboxyl, tetrazol-5-yl and --CH.dbd.CHCOOH; orwherein R.sup.1 and R.sup.2 taken together can represent a group of formula --CH.dbd.CH--CH.dbd.CH-- provided that at least one of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is carboxyl, tetrazol-5-yl or --CH.dbd.CHCOOH;or a pharmaceutically-acceptable salt or ester thereof, are effective in the prophylactic chemotherapy of allergic conditions such as bronchial asthma.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: July 1, 1986
    Assignee: Lilly Industries Limited
    Inventors: Stephen R. Baker, William B. Jamieson, William J. Ross
  • Patent number: D284548
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: July 8, 1986
    Assignee: Eli Lilly and Company
    Inventor: Marc A. Rosen