Patents Represented by Attorney Arthur S. Morgenstern

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  • Polysubstituted aryl acridinium esters
    Patent number: 5110932
    Abstract: The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay.
    Type: Grant
    Filed: March 1, 1990
    Date of Patent: May 5, 1992
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Steve C. S. Chang, Stephen A. Palmacci, Roger S. Cubicciotti
  • Process for stabilizing liposomes
    Patent number: 5094785
    Abstract: The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.
    Type: Grant
    Filed: November 22, 1989
    Date of Patent: March 10, 1992
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Uri Piran
  • Method for enhancing signal release from liposomes using water-miscible alcohols
    Patent number: 5093270
    Abstract: A method for releasing encapsulated marker molecules from within liposomes comprises contracting the liposomes with an effective amount of a water-miscible alcohol. The chemiluminescence of acridinium esters is enhanced by oxidizing the acridinium ester in the presence of an effective amount of a water-miscible alcohol.
    Type: Grant
    Filed: May 24, 1989
    Date of Patent: March 3, 1992
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Steve C. S. Chang, Say-Jong Law
  • Unitary multiple electrode sensor
    Patent number: 5066372
    Abstract: A unitary multiple electrode sensor for detecting analytes in test samples and devices for using them. The unitary multiple electrode sensor includes a sensor support member and at least one electrode array being deposited on the sensor support member, the electrode array having sensor-activating chemical(s) attached to an embodient thereof. A test sample is applied to the electrode array to begin the test; and a sensor apparatus measures the test reaction which is occurring on the electrode array.
    Type: Grant
    Filed: June 21, 1990
    Date of Patent: November 19, 1991
    Assignee: Ciba Corning Diagnostics Corp.
    Inventor: Howard H. Weetall
  • Stabilized stain solutions containing aliphatic and aromatic alcohols
    Patent number: 4816244
    Abstract: Medium molecular weight alcohols (for example aliphatic alcohols, such as trihydroxypentane and trihydroxyhexane, and aromatic alcohols, such as benzylalcohol) have been found to provide unexpected stability to dye and stain solutions. In addition, the use of these alcohols does not involve the negatives found in other dye stabilizers, for example extreme flammability and toxicity. The novel alcohols have been found to provide benefit to many dye systems.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: March 28, 1989
    Assignee: Sigma Chemical Company
    Inventor: William H. Starkweather
  • Rapid, accurate method of separation of oxalate from urine and other biological fluids
    Patent number: 4539118
    Abstract: A novel technique has been discovered for separating oxalate from urine and other biological fluids. The method involves mixing the fluid with an adsorbent to separate the oxalate from the fluids, washing the adsorbent-oxalate complex, and releasing the oxalate by reacting the complex with alkali. This technique provides accurate results and can easily be run in hospitals and clinical laboratories.
    Type: Grant
    Filed: March 23, 1984
    Date of Patent: September 3, 1985
    Assignee: Sigma Chemical Company
    Inventor: Quincy E. Crider
  • Cuvette for a clinical laboratory analyzer
    Patent number: D330428
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: October 20, 1992
    Inventors: Scott Lewis, Glen Carey
  • Reagent bottle for a clinical laboratory analyzer
    Patent number: D330429
    Type: Grant
    Filed: July 20, 1990
    Date of Patent: October 20, 1992
    Inventors: Scott Lewis, Mary B. Whitesel