Patents Represented by Attorney Audrey Sher

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  • Methods for treating immune system diseases using a soluble CTLA4 molecule
    Patent number: 7455835
    Abstract: The present invention relates to compositions and methods for treating rheumatic disease by administering to a subject, soluble CTLA4 molecules that block endogenous B7 molecules from binding their ligands.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: November 25, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert Cohen, Robert James Peach, David Hagerty, Suzette Carr, Jean-Claude Becker, Peter S. Linsley, Joseph Roy Naemura, Jurgen Bajorath
  • N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor
    Patent number: 7119188
    Abstract: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: October 10, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Venkata B. Nanduri, Ramesh N. Patel, Steven L. Goldberg, Robert M. Johnston
  • Soluble CTLA4 mutant molecules and uses thereof
    Patent number: 7105166
    Abstract: The present invention provides soluble CTLA4 mutant molecules which bind CD80 and/or CD86 antigen.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 12, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter S. Linsley, Jeffrey A. Ledbetter, Jurgen Bajorath, Robert J. Peach, William Brady, Philip Wallace, Nitin Damle
  • Amide and diamide inhibitors of IMPDH enzyme for use in treating IMPDH-associated disorders
    Patent number: 6624184
    Abstract: The present invention discloses the identification of the inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 23, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz