Abstract: The invention relates to novel methods for using macrolide anti-infective agents. The macrolide anti-infective agents demonstrate antibacterial activity against multi-drug resistant strains of bacteria and, in particular, methicillin-resistant Staphylococcus aureus (MRSA). Methods for inhibiting the activity of multi-drug resistant bacterial organisms and methods for treating a bacterial infection caused by such organisms are described herein.
Type:
Grant
Filed:
February 23, 2001
Date of Patent:
September 20, 2005
Assignee:
Abbott Laboratories
Inventors:
Zhenkun Ma, Peter Nemoto, Suoming Zhang, Hong Yong, Yat Sun Or
Abstract: Antibacterials having formula (I)
and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
Type:
Grant
Filed:
March 12, 2003
Date of Patent:
November 16, 2004
Assignee:
Abbott Laboratories
Inventors:
David Anderson, Bruce Beutel, Curt Cooper, Peter Dandliker, Caroline David, Yu-Gui Gu, Mira Hinman, Douglas Kalvin, Linda Lynch, Zhenkun Ma, Christopher Motter, Teresa Rosenberg, William Sanders, Michael Tufano, Rolf Wagner, Moshe Weitzberg, Hong Yong
Abstract: Compounds of formula (I)
and formula (II)
or therapeutically acceptable salts or prodrugs thereof are useful as antibacterial agents. Methods to make the compounds, compositions containing the compounds, and methods of treatment using the compounds are also disclosed.
Type:
Grant
Filed:
January 16, 2002
Date of Patent:
December 23, 2003
Assignee:
Abbott Laboratories
Inventors:
Zhenkun Ma, Ly Tam Phan, Suoming Zhang, Stevan W. Djuric
Abstract: The present invention provides compounds of formula Ia and Ib
or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.
Type:
Grant
Filed:
September 22, 2000
Date of Patent:
July 15, 2003
Assignee:
Abbott Laboratories
Inventors:
Clarence J. Maring, Vincent L. Giranda, Yu Gui Gu, Stephen Hanessian, Dale J. Kempf, Darold L. Madigan, Kent Stewart, Vincent S. Stoll, Minghua Sun, Gary T. Wang, Jianchio Wang, Chen Zhao
Abstract: The present invention relates to 6-O-alkyl-2-nor-2-substituted ketolide compound or a derivative thereof, a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of in mammals comprising administering said compound.