Patents Represented by Attorney, Agent or Law Firm B. Gregory Donner
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Patent number: 7491718Abstract: Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.Type: GrantFiled: October 8, 2003Date of Patent: February 17, 2009Assignee: Abbott LaboratoriesInventors: Kenneth M. Comess, Scott A. Erickson, Jack Henkin, Douglas M. Kalvin, Megumi Kawai, Ki H. Kim, Nwe Y. BaMaung, Chang Hoon Park, George S. Sheppard, Anil Vasudevan, Jieyi Wang, David M. Barnes, Steve D. Fidanze, Lawrence Kolaczkowski, Robert A. Mantei, David C. Park, William J. Sanders, Jason S. Tedrow, Gary T. Wang
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Patent number: 7470691Abstract: The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D and B1 are as described in the specification.Type: GrantFiled: May 14, 2007Date of Patent: December 30, 2008Assignee: Abbott LaboratoriesInventors: Marlon D. Cowart, Steven P. Latshaw, Sherry L. Nelson, Andrew O. Stewart
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Patent number: 7468371Abstract: Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: March 24, 2005Date of Patent: December 23, 2008Assignee: Abbott Laboratories Inc.Inventors: Lee D. Arnold, Jürgen Dinges, Richard W. Dixon, Stevan W. Djuric, Anna M. Ericsson, Kimba Fischer, Alan F. Gasiecki, Vijaya J. Gracias, James H. Holms, Makoto Takeshita, Michael R. Michaelides, Melanie A. Muckey, Paul Rafferty, Douglas H. Steinman, Carol K. Wada, Zhiren Xia, Irini Akritopoulou-Zanze, Henry Q. Zhang
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Patent number: 7456169Abstract: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: August 23, 2006Date of Patent: November 25, 2008Assignee: Abbott Laboratories Inc.Inventors: Lisa A. Hasvold, Laura Hexamer, Gaoquan Li, Nan-Horng Lin, Hing Sham, Thomas J. Sowin, Gerard M. Sullivan, Le Wang, Ping Xia
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Patent number: 7449584Abstract: N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.Type: GrantFiled: January 13, 2006Date of Patent: November 11, 2008Assignee: Abbott Laboratories Inc.Inventors: Eric A. Schmitt, Ira S. Buckner, Geoff G. Z. Zhang, Rodger F. Henry
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Patent number: 7449485Abstract: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: February 26, 2008Date of Patent: November 11, 2008Assignee: Abbott Laboratories Inc.Inventors: Steven W. Elmore, Cheol-Min Park, Xilu Wang
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Patent number: 7446206Abstract: N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.Type: GrantFiled: January 13, 2006Date of Patent: November 4, 2008Assignee: Abbott Laboratories Inc.Inventors: Eric A. Schmitt, Ira S. Buckner, Geoff G. Z. Zhang, Rodger F. Henry
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Patent number: 7432245Abstract: Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations.Type: GrantFiled: June 6, 2003Date of Patent: October 7, 2008Assignee: Abbott Laboratories Inc.Inventors: Fortuna Haviv, Bryan K. Erickson, Jack Henkin, Luk C. Li, Fanfeng Ma, Friedrich W. Richter, Yi Shi, Jingfeng Song, Siriporn Toongsuwan
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Patent number: 7395928Abstract: A child-resistant blister card package is disclosed having a plurality of unit package regions for enclosing one unit dosage form, each comprising a cavity and a closure sheet to seal the cavity. Once a unit package region is detached, the corner defined by lines of weakening with perforations can be detached to expose an unsealed area and easily access the content of each unit package region.Type: GrantFiled: July 14, 2005Date of Patent: July 8, 2008Assignee: Abbott LaboratoriesInventors: Shane Kenneth Bertsch, Steven E. Breitenstein
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Patent number: 7365093Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.Type: GrantFiled: February 23, 2005Date of Patent: April 29, 2008Assignee: Abbott LaboratoriesInventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
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Patent number: 7358251Abstract: Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: November 29, 2005Date of Patent: April 15, 2008Assignee: Abbott LaboratoriesInventors: Steven W. Elmore, Cheol-Min Park, Xilu Wang
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Patent number: 7208517Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for the inhibition of bone metastases, methods for the prevention of growth of new metastases, methods for the inhibition of bone turnover, and methods for the prevention of bone loss in patients, including cancer patients, using an endothelin ET-A receptor antagonist.Type: GrantFiled: August 31, 2000Date of Patent: April 24, 2007Assignee: Abbott LabortoriesInventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King, Todd J. Janus, Robert J. Padley
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Patent number: 7202363Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: July 26, 2004Date of Patent: April 10, 2007Assignee: Abbott LaboratoriesInventors: Patrick Betschmann, Andrew F. Burchat, David J. Calderwood, Michael L. Curtin, Steven K. Davidsen, Heather M. Davis, Robin R. Frey, Howard R. Heyman, Gavin C. Hirst, Peter Hrnciar, Michael R. Michaelides, Melanie A. Muckey, Kelly D. Mullen, Paul Rafferty, Carol K. Wada
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Patent number: 7196200Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.Type: GrantFiled: January 21, 2004Date of Patent: March 27, 2007Assignee: Abbott LaboratoriesInventors: David D. Anderson, Bruce A. Beutel, Curt S. Cooper, Yu-Gui Gu, Mira M. Hinman, Douglas M. Kalvin, Robert F. Keyes, Xenia B. Searle, Rolf Wagner
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Patent number: 7135468Abstract: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.Type: GrantFiled: February 4, 2005Date of Patent: November 14, 2006Assignee: Abbott LaboratoriesInventors: Mira M. Hinman, Teresa A. Rosenberg, Rolf Wagner
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Patent number: 7135484Abstract: Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system.Type: GrantFiled: August 12, 2003Date of Patent: November 14, 2006Assignee: Abbott LaboratoriesInventors: Michael J. Dart, Xenia B. Searle, Karin R. Tietje, Richard B. Toupence
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Patent number: 7129260Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.Type: GrantFiled: June 2, 2004Date of Patent: October 31, 2006Assignee: Abbott LaboratoriesInventors: Michael L. Curtin, Steven K. Davidsen, Robin R. Frey, Howard R. Heyman, James H. Holms, Michael Michaelides, Douglas H. Steinman
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Patent number: 7074932Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.Type: GrantFiled: May 7, 2003Date of Patent: July 11, 2006Inventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul J. Nichols, Hemant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
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Patent number: 7071314Abstract: An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl macrolide can be obtained in a much shorter reaction time than under conventional Heck reaction conditions. The modified Heck reaction can be utilized in a method for phosphine-free arylation of an O-allylic erythromycin derivative, in a method for preparing an O-alkenylaryl erythromycin A derivative, or in a method for preparing a 2?, 4?-hydroxyl protected 6-O-alkenylaryl erythromycin A derivative.Type: GrantFiled: May 28, 2002Date of Patent: July 4, 2006Assignee: Abbott LaboratoriesInventors: Weijang Zhang, Margaret Chi-Ping Hsu, Anthony R. Haight, Matthew John Peterson, Bikshandarkoil A. Narayanan
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Patent number: 7030262Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.Type: GrantFiled: August 6, 2003Date of Patent: April 18, 2006Assignee: Abbott LaboratoriesInventors: Nwe Y. BaMaung, Richard A. Craig, Jack Henkin, Megumi Kawai, Xenia B. Searle, George S. Sheppard, Jieyi Wang