Abstract: The present invention relates to an organopolysiloxane composition that can be vulcanized at room temperature into an elastomer that is crosslinked by polycondensation and that does not contain alkyltin-based catalysts and also to novel organopolysiloxane polycondensation catalysts.
Type:
Grant
Filed:
November 18, 2008
Date of Patent:
August 14, 2012
Assignee:
Bluestar Silicones France S.A.S.
Inventors:
Christian Maliverney, Laurent Saint-Jalmes
Abstract: The invention describes phenyl-substituted pyridazinones of the formula (I) as herbicides and insecticides. In this formula (I), A, B, G, X, Y and Z are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen, nitro and cyano.
Type:
Grant
Filed:
December 15, 2009
Date of Patent:
August 14, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Stefan Lehr, Thomas Schenke, Christopher Hugh Rosinger, Reiner Fischer, Isolde Häuser-Hahn, Dieter Feucht, Jan Dittgen, Pierre Cristau, Oliver Gaertzen, Stefan Herrmann, Olga Malsam, Eva-Maria Franken
Abstract: The invention relates to a tumor-associated peptide with an amino acid sequence selected from the group consisting of SEQ ID NO. 1 to SEQ ID NO. 577 from the attached sequence protocol, the peptide being capable of binding to a molecule of the human major histocompatibility complex (MHC) class I. The invention further relates to the use of the peptides for preparation of a drug and for the treatment of tumor diseases and/or adenomatous diseases. Furthermore, a pharmaceutical composition is described comprising at least one of the peptides.
Type:
Grant
Filed:
August 19, 2009
Date of Patent:
August 14, 2012
Assignee:
Immatics Biotechnologies GmbH
Inventors:
Toni Weinschenk, Claudia Lemmel, Hans-Georg Rammensee, Stefan Stevanovic
Abstract: The present disclosure pertains to a blend of aromatic polycarbonate and polylactic acid, the method for preparing the same and the use thereof. In the present invention a transesterification catalyst is added during the preparing process with regard to the blend of aromatic polycarbonate and polylactic acid to improve the compatibility of the components in the blend. The blend of aromatic polycarbonate and polylactic acid is provided with the good mechanical properties, thermal processibility and flame retardance properties, and can be widely applied to mechanical product or parts, electronic equipments and/or parts, construction material and/or commodities.
Abstract: The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on propamocarb-fosetylate, an insecticide active substance and optionally a further fungicide active substance.
Type:
Grant
Filed:
December 21, 2007
Date of Patent:
August 7, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Koen Van Den Eynde, Marc Andrieux, Heike Hungenberg, Wolfgang Thielert, Anne Suty-Heinze
Abstract: The present invention relates to compounds as inhibitors of enzymes having histone deacetylase activity, to the processes for the preparation of those compounds, and to their use for the treatment of diseases which are associated with hypoacetylation of histones and/or other molecules, or in which induction of hyperacetylation has a beneficial effect for example by inhibition of proliferation and/or induction of differentiation and/or induction of apoptosis in transformed cells, such as cancer. Furthermore, the compounds are useful for the treatment of other proliferative diseases, for therapy or prophylaxis of conditions associated with abnormal gene expression.
Type:
Grant
Filed:
July 16, 2007
Date of Patent:
July 24, 2012
Assignee:
4SC Discovery GmbH
Inventors:
Alexander B. Maurer, Sascha Hoevelmann, Elke Martin, Bernd Hentsch, Michael Gassen, Juergen Kraus, Rolf Krauss, Adam-Spencer Vincek
Abstract: The present invention relates to a pesticide composition intended for protecting plants, crops or seeds against phyto-pathogenic fungi or damaging insects, and the corresponding methods of treatment using the said composition. More precisely, the subject of the present invention is a pesticide composition based on propamocarb-HCl, an insecticide active substance and optionally a further fungicide active substance.
Type:
Grant
Filed:
December 21, 2007
Date of Patent:
July 10, 2012
Assignee:
Bayer Intellectual Property GmbH
Inventors:
Koen van Den Eynde, Wolfgang Thielert, Heike Hungenberg
Abstract: A process for the manufacture of plated strips comprising at least two layers of different metals or alloys. The process allows subsequent separation of different cropped layers resulting from shearing the plated strips. The process comprises preparing plates corresponding to each of the plating layers, superimposing and assembly of these plates to form a composite plate, hot and possibly cold rolling of this composite plate to obtain a plated strip, and shearing of cropping areas during or after rolling. In one embodiment, prior to superimposing the different plates, an anti-sticking agent is applied to the cropping areas of at least one of the surfaces of the plates which will be in contact with each other.
Type:
Grant
Filed:
June 1, 2004
Date of Patent:
July 3, 2012
Assignee:
Constellium France
Inventors:
Sandrine Dulac, Christian Barthelemy, Sylvain Henry, Armand Gabriel
Abstract: The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumor cell lines which can be used in vaccine compositions for eliciting anti-tumor immune responses.
Abstract: The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumor cell lines which can be used in vaccine compositions for eliciting anti-tumor immune responses.
Abstract: The present invention relates to a method for the production of polarization holograms, an apparatus for the production of polarization holograms and the use of the polarization holograms according to the invention as data stores, security features or diffractive optical elements for performing conventional optical functions.
Type:
Grant
Filed:
January 31, 2007
Date of Patent:
June 26, 2012
Assignee:
Bayer Innovation GmbH
Inventors:
Jean-Michel Asfour, Stephan Schneider, Dietmar Eberhard, Wolfgang Riedel, Dominik Giel, Stephan Völkening, Hardy Jüngermann
Abstract: The present invention is related to a method for isolating a target nucleic acid from a sample comprising said target nucleic acid, comprising the steps of mixing a sample containing said target nucleic acid with a binding solution and a nucleic acid binding matrix, binding at least part of said target nucleic acid to said nucleic acid binding matrix, wherein said nucleic acid binding matrix is treated simultaneously or has been previously treated with at least one compound comprising a metal substance selected from the group consisting of metals of the main groups 13 to 16, semimetals and transition metals for reducing non-target nucleic acid contaminations or wherein said nucleic acid binding matrix is modified with hydrophobic groups. Furthermore, respective kits and reagents are provided with the teaching of the present invention.
Type:
Grant
Filed:
October 10, 2007
Date of Patent:
June 26, 2012
Assignee:
Qiagen GmbH
Inventors:
Christoph Ritt, Christoph Erbacher, Patrick Baumhof
Abstract: Described is a method for producing a molded silicone rubber product using a liquid silicone rubber (LSR) base comprising at least one vinyl siloxane polymer, at least one hydride crosslinker, and optionally at least one injection molding inhibitor. The single LSR base is fed into a feed line, and into the feed line are fed an inhibitor master batch comprising at least one liquid injection molding inhibitor and at least one vinyl siloxane polymer, and a catalyst master batch comprising at least one catalyst and at least one vinyl siloxane polymer. The invention is further directed to: said LSR base; said inhibitor master batch; said catalyst master batch; and a molded silicone rubber article produced by the methods and compositions described herein.
Type:
Grant
Filed:
June 9, 2011
Date of Patent:
June 12, 2012
Assignee:
Bluestar Silicones USA Corp.
Inventors:
Edward Jeram, Reeshemah Beaty Chatham, Robert Higley
Abstract: The present invention relates to biomedical foam articles for the wound sector which are formed by spraying a polymeric dispersion onto a wound. The polymeric dispersion being sprayed onto a wound surface forms a three-dimensional body which conforms to the spatial shape of the wound and which, as well as covering the wound surface, ensures a complete and accurately fitted packing of the wound in the depth dimension as well as the other dimensions. The biomedical foam articles of the present invention are particularly useful for treating chronic wounds.
Type:
Grant
Filed:
April 5, 2007
Date of Patent:
June 12, 2012
Assignees:
Bayer Innovation GmbH, Bayer Materialscience AG
Inventors:
Melita Dietze, Burkhard Fugmann, Michael Mager, Thorsten Rische, Michael Heckes, Daniel Rudhardt, Rolf Gertzmann
Abstract: Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase activity, e.g., lipases, saturases, palmitases and/or stearatases and methods for preparing low saturate or low trans fat oils, such as low saturate or low trans fat animal or vegetable oils, e.g., soy or canola oils.
Type:
Grant
Filed:
August 29, 2008
Date of Patent:
June 12, 2012
Assignee:
DSM IP Assets B.V.
Inventors:
Timothy Hitchman, Christopher L. G. Dayton, Katie A. Kline, Jonathan Lyon, Mark Wall, Nelson R. Barton
Abstract: 2-(3-Alkylthiobenzoyl)cyclohexanediones of the formula (I) are described as herbicides. In this formula (I), X, Y, R1 to R8 represent radicals such as hydrogen, organic radicals such as alkyl and alkoxy.
Type:
Grant
Filed:
July 27, 2010
Date of Patent:
June 5, 2012
Assignee:
Bayer Cropscience AG
Inventors:
Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Stefan Lehr, Dieter Feucht
Abstract: The present invention relates to novel C2-phenyl-substituted cyclic ketoenols, to a plurality of processes for their preparation and to their use as pesticides as herbicides.
Type:
Grant
Filed:
February 17, 2011
Date of Patent:
June 5, 2012
Assignee:
Bayer Aktiengesellschaft
Inventors:
Michael Ruther, Hermann Hagemann, Udo Schneider, Markus Dollinger, Peter Dahmen, Ulrike Wachendorff-Neumann, Reiner Fischer, Alan Graff, Thomas Bretschneider, Christophe Erdelen, Mark Wilhelm Drewes, Dieter Feucht, Folker Lieb
Abstract: A polyorganosiloxane composition that can be vulcanized at high temperature to a silicone elastomer, useful in the field of the manufacture of electrical wires or cables having an improved fire performance is provided. The composition includes a semi-reinforcing filler chosen from the group composed of:—calcined kaolin powders, preferably that have undergone a chemical surface treatment;—talc;—calcium carbonate that may or may not have been surface-treated, for example with vinylsilanes, aminosilanes or (reactive or unreactive) silicone oils; and mixtures thereof.