Patents Represented by Attorney Balaram Gupta
  • Patent number: 8080559
    Abstract: A 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: December 20, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Venkateswarlu Akella, Shanavas Alikunju, Ajaya Kumar Reka, Ramesh Mullangi, Raju Sirisilla, Subrahmanyam Duvvuri, Sriram Rajagopal
  • Patent number: 8080668
    Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5?-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: December 20, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Vijay Kumar Potluri, Saibal Kumar Das, Pradip Kumar Sasmal, Javed Iqbal, Parimal Misra, Ranjan Chakrabarti, Rashmi Talwar
  • Patent number: 8063214
    Abstract: A process for preparing crystalline Form A of tadalafil (I), comprising crystallization from a solution of tadalafil in a solvent comprising a C3-C7 ester, a ketone, dimethylformamide, dimethylsulfoxide, ethanol, acetonitrile, a chlorinated hydrocarbon, t-butanol, N,N-dimethylacetamide, dioxane, N-methyl pyrrolidone, or a mixture of any two or more thereof.
    Type: Grant
    Filed: October 26, 2005
    Date of Patent: November 22, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Eswaraiah Sajja, Venkata Naga Kali Vara Prasada Raju Vetukuri, Srinivas Reddy Ningam, Ravindra Vedantham, Rajyalakshmi Bodepudi
  • Patent number: 8008328
    Abstract: Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: August 30, 2011
    Assignee: Reddy US Therapeutics, Inc.
    Inventors: Uday Saxena, Sivaram Pillarisetti, Ish Khanna
  • Patent number: 7989463
    Abstract: Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided: wherein R1, R2, m, and n are defined herein.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: August 2, 2011
    Assignee: Dr. Reddy's Laboratories Limited
    Inventors: Dibyendu De, Ish Kumar Khanna, Sivaram Pillarisetti
  • Patent number: 7939513
    Abstract: In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds. wherein R1 is selected from optionally substituted alkyl.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: May 10, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Mohamed Takhi, Natesan Selvakumar, Sreenivas Kandepu, Gavara Govinda Rajulu, Javed Iqbal
  • Patent number: 7879889
    Abstract: The present invention discloses and claims therapeutic uses of a compound corresponding to the general formula (I): Wherein, X, R1, R2, R3, R4, R5, R5?, R6 and n are as described herein.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis
    Inventors: Pierre Despey-Roux, Daniel Frehel, Bruno Schoentjes, Viviane Van Dorsselaer
  • Patent number: 7879902
    Abstract: The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds including the intermediates therefor and their therapeutic use.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
  • Patent number: 7875646
    Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: January 25, 2011
    Assignee: Sanofi-Aventis
    Inventors: Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
  • Patent number: 7868007
    Abstract: The invention relates to the triazolopyridine carboxamide derivatives of general formula (I): Wherein X, A, R1 and R2 are as defined herein. The invention further relates to preparation methods and therapeutic use thereof.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: January 11, 2011
    Assignee: sanofi-aventis
    Inventor: Christian Hoornaert
  • Patent number: 7863279
    Abstract: The invention relates to the triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives of general formula (I): Wherein X, A, R1 and R2 are as defined herein. The invention further relates to preparation methods and therapeutic use thereof.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: January 4, 2011
    Assignee: sanofi-aventis
    Inventors: Luc Even, Christian Hoornaert
  • Patent number: 7863290
    Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 4, 2011
    Assignee: sanofi-aventis
    Inventors: Frederic Galli, Odile LeClerc, Alistair Lochead, Julien Vache
  • Patent number: 7838547
    Abstract: The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: November 23, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Lothar Schwink, Siegfried Stengelin, Matthias Gossel, Gerhard Hessler, Petra Lenning
  • Patent number: 7824919
    Abstract: A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes the step of chromatographing a sample of the mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)n H, RO(C2H4O)nA, and AO(C2H4O)nA in the mixture. In addition a chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a biologically active material and n is an integer greater than 10. The method includes two steps.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: November 2, 2010
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Ross A. Wallingford, Maciej Turowski
  • Patent number: 7816484
    Abstract: A method for preparing a polyalkylene glycol carbonate is disclosed comprising reacting a hydroxyl functional polyalkylene glycol and a reagent selected from carbonates and chloroformates in the presence of an aromatic solvent and an amine.
    Type: Grant
    Filed: February 27, 2007
    Date of Patent: October 19, 2010
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventor: Daniel E. Verral
  • Patent number: 7803763
    Abstract: The invention relates to a method for the chromatographic purification of preproinsulins, in which higher molecular weight substances are removed from an aqueous solution of preproinsulin by a first chromatography on an anion exchanger in flow-through mode and a subsequent second chromatography on a cation exchanger in adsorption mode, and to a method for preparing insulins, which includes the method for preparing preproinsulins.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: September 28, 2010
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Horst Thurow, Hans Blumenstock, Chantalle Havenith
  • Patent number: 7795289
    Abstract: This invention discloses and claims a method of treatment of a disease as defined herein using a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. Specifically, the compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.
    Type: Grant
    Filed: September 21, 2007
    Date of Patent: September 14, 2010
    Assignee: Sanofi-Aventis
    Inventors: Sylvie Baltzer, Bruno Schoentjes, Viviane Van Dorsselaer
  • Patent number: 7786104
    Abstract: The invention concerns compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z, Z1, Z2, Z3 and Z4 are as defined herein. The invention also concerns a process for the preparation of compounds of formula (I) and their therapeutic use.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: August 31, 2010
    Assignee: Sanofi-Aventis
    Inventors: Laurent DuBois, Yannick Evanno, Andre Malanda, David Machnik, Catherine Gille
  • Patent number: 7781440
    Abstract: The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3? or GSK3? and cdk5/p25, such as Alzheimer disease.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: August 24, 2010
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • Patent number: 7781477
    Abstract: The invention relates to therapeutic use of compounds of general formula (I): in which X1, X2, X3, X4, X5, Z1, Z2, Z3, Z4 and Z5, R, Y and n are as defined herein.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Laurent Dubois, Yannick Evanno, Luc Even