Abstract: The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5?-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds.
Type:
Grant
Filed:
June 30, 2006
Date of Patent:
December 20, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: A 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2?-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2?-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
Type:
Grant
Filed:
October 12, 2009
Date of Patent:
December 20, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: A process for preparing crystalline Form A of tadalafil (I), comprising crystallization from a solution of tadalafil in a solvent comprising a C3-C7 ester, a ketone, dimethylformamide, dimethylsulfoxide, ethanol, acetonitrile, a chlorinated hydrocarbon, t-butanol, N,N-dimethylacetamide, dioxane, N-methyl pyrrolidone, or a mixture of any two or more thereof.
Type:
Grant
Filed:
October 26, 2005
Date of Patent:
November 22, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Inventors:
Eswaraiah Sajja, Venkata Naga Kali Vara Prasada Raju Vetukuri, Srinivas Reddy Ningam, Ravindra Vedantham, Rajyalakshmi Bodepudi
Abstract: Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.
Type:
Grant
Filed:
December 28, 2007
Date of Patent:
August 30, 2011
Assignee:
Reddy US Therapeutics, Inc.
Inventors:
Uday Saxena, Sivaram Pillarisetti, Ish Khanna
Abstract: Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of forming novel bicyclic compounds, stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided: wherein R1, R2, m, and n are defined herein.
Type:
Grant
Filed:
September 3, 2009
Date of Patent:
August 2, 2011
Assignee:
Dr. Reddy's Laboratories Limited
Inventors:
Dibyendu De, Ish Kumar Khanna, Sivaram Pillarisetti
Abstract: In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds. wherein R1 is selected from optionally substituted alkyl.
Type:
Grant
Filed:
September 8, 2008
Date of Patent:
May 10, 2011
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: The present invention discloses and claims therapeutic uses of a compound corresponding to the general formula (I): Wherein, X, R1, R2, R3, R4, R5, R5?, R6 and n are as described herein.
Type:
Grant
Filed:
June 22, 2009
Date of Patent:
February 1, 2011
Assignee:
Sanofi-Aventis
Inventors:
Pierre Despey-Roux, Daniel Frehel, Bruno Schoentjes, Viviane Van Dorsselaer
Abstract: The invention concerns compounds of formula (I): Wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined herein. The invention also concerns the method for preparing said compounds including the intermediates therefor and their therapeutic use.
Type:
Grant
Filed:
April 14, 2008
Date of Patent:
February 1, 2011
Assignee:
Sanofi-Aventis
Inventors:
Francis Barth, Christian Congy, Laurent Hortala, Murielle Rinaldi-Carmona
Abstract: The present invention relates to compounds corresponding to the formula (I): In which R1, R2, R3, R4 and R5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.
Type:
Grant
Filed:
September 21, 2007
Date of Patent:
January 25, 2011
Assignee:
Sanofi-Aventis
Inventors:
Francis Barth, Christian Congy, Serge Martinez, Philippe Pointeau, Murielle Rinaldi-Carmona
Abstract: The invention relates to the triazolopyridine carboxamide derivatives of general formula (I): Wherein X, A, R1 and R2 are as defined herein. The invention further relates to preparation methods and therapeutic use thereof.
Abstract: The invention relates to the triazolopyridine carboxamide derivatives and triazolopyrimidine carboxamide derivatives of general formula (I): Wherein X, A, R1 and R2 are as defined herein. The invention further relates to preparation methods and therapeutic use thereof.
Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
Abstract: The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; where the symbols and radicals are explained in the description, as well as to pharmaceutical compositions containing them and to methods of treatment using them.
Type:
Grant
Filed:
February 13, 2007
Date of Patent:
November 23, 2010
Assignee:
Sanofi-Aventis Deutschland GmbH
Inventors:
Lothar Schwink, Siegfried Stengelin, Matthias Gossel, Gerhard Hessler, Petra Lenning
Abstract: A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes the step of chromatographing a sample of the mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)n H, RO(C2H4O)nA, and AO(C2H4O)nA in the mixture. In addition a chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a biologically active material and n is an integer greater than 10. The method includes two steps.
Type:
Grant
Filed:
March 4, 2005
Date of Patent:
November 2, 2010
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: A method for preparing a polyalkylene glycol carbonate is disclosed comprising reacting a hydroxyl functional polyalkylene glycol and a reagent selected from carbonates and chloroformates in the presence of an aromatic solvent and an amine.
Type:
Grant
Filed:
February 27, 2007
Date of Patent:
October 19, 2010
Assignees:
Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
Abstract: The invention relates to a method for the chromatographic purification of preproinsulins, in which higher molecular weight substances are removed from an aqueous solution of preproinsulin by a first chromatography on an anion exchanger in flow-through mode and a subsequent second chromatography on a cation exchanger in adsorption mode, and to a method for preparing insulins, which includes the method for preparing preproinsulins.
Type:
Grant
Filed:
December 15, 2005
Date of Patent:
September 28, 2010
Assignee:
Sanofi-Aventis Deutschland GmbH
Inventors:
Horst Thurow, Hans Blumenstock, Chantalle Havenith
Abstract: This invention discloses and claims a method of treatment of a disease as defined herein using a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. Specifically, the compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.
Type:
Grant
Filed:
September 21, 2007
Date of Patent:
September 14, 2010
Assignee:
Sanofi-Aventis
Inventors:
Sylvie Baltzer, Bruno Schoentjes, Viviane Van Dorsselaer
Abstract: The invention concerns compounds of general formula (I): Wherein n, X1, X2, X3, X4, Y, Z, Z1, Z2, Z3 and Z4 are as defined herein. The invention also concerns a process for the preparation of compounds of formula (I) and their therapeutic use.
Type:
Grant
Filed:
January 26, 2009
Date of Patent:
August 31, 2010
Assignee:
Sanofi-Aventis
Inventors:
Laurent DuBois, Yannick Evanno, Andre Malanda, David Machnik, Catherine Gille
Abstract: The present invention comprises peridinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
Type:
Grant
Filed:
August 21, 2006
Date of Patent:
August 24, 2010
Assignee:
Sanofi-Aventis
Inventors:
Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Jean Jeunesse
Abstract: The invention concerns compounds of formula (I): Wherein X, R1, R2, R3 and R4 are as described herein. The invention also concerns a method for preparing same and the therapeutic use thereof.
Type:
Grant
Filed:
May 22, 2008
Date of Patent:
August 24, 2010
Assignee:
Sanofi-Aventis
Inventors:
Francis Barth, Murielle Rinaldi-Carmona