Abstract: As a step towards understanding the complex differences between normal and cancer cells, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insights into the extent of expression differences underlying malignancy and reveal genes that are useful as diagnostic or prognostic markers.
Type:
Grant
Filed:
May 20, 1998
Date of Patent:
December 25, 2001
Assignee:
The JohnsHopkins University
Inventors:
Bert Vogelstein, Kenneth W. Kinzler, Lin Zhang, Wei Zhou