Patents Represented by Attorney, Agent or Law Firm Banner and Witcoff
  • Chimeric proteins
    Patent number: 6174721
    Abstract: Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: January 16, 2001
    Assignee: Chiron Corporation
    Inventors: Michael A. Innis, Abla A. Creasey
  • Production of tissue factor pathway inhibitor
    Patent number: 6103500
    Abstract: A method for the production of Tissue Factor Pathway Inhibitor (TFPI) and Tissue Factor Pathway Inhibitor 2 (TFPI-2), and muteins thereof is disclosed wherein the protein is retained within a yeast cell during growth of the yeast cell and recovered from an insoluble fraction prepared from yeast cells containing the protein.
    Type: Grant
    Filed: May 12, 1997
    Date of Patent: August 15, 2000
    Assignee: Chiron Corporation
    Inventors: Michael A. Innis, Abla A. Creasey