Abstract: The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
Type:
Grant
Filed:
October 5, 2001
Date of Patent:
November 21, 2006
Assignee:
Amgen, Inc.
Inventors:
John Flygare, Julio C. Medina, Bei Shan, David L. Clark, Terry J. Rosen