Abstract: Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a checkpoint gene-defective human cell.
Type:
Grant
Filed:
April 10, 2001
Date of Patent:
January 28, 2003
Assignee:
The Johns Hopkins University
Inventors:
Bert Vogelstein, Todd Waldman, Christoph Lengauer, Kenneth W. Kinzler
Abstract: A semiconductor memory integrated circuit is provided, which is capable of simultaneously applying voltage stress to normal signal lines and spare signal lines, thereby reducing the time required for performing a test. The semiconductor memory integrated circuit includes a memory cell array having a plurality of normal signal lines for selecting a memory cell, a redundant cell array including three or more of odd number of spare signal lines for compensating for defectiveness in the memory cell array, a decoder for decoding an address signal to select a normal signal line, a spare decoder, which is activated when a defective address signal is inputted, for decoding the defective address signal to select a spare signal line, and a test control circuit for controlling the decoder and the spare decoder to perform a test of applying voltage between adjacent signal lines in the normal signal lines and the spare signal lines.
Abstract: A low-cost, compact room slideout assembly is provided for driving a sliding element, such as a floor, and comprises at least one motor having a motor output pinion rotatable about a first axis, a drive screw operatively connected to the motor output and rotatable about the first axis, and a driving member, such an elongate ram adapted to be attached to the sliding element. The ram travels along the first axis between extended and retracted positions in response to rotation of the motor output shaft. Preferably operatively connected between the motor output shaft and the drive screw is a speed reducing gearbox with an output shaft rotatable about the first axis, and a 90 degree gearbox operatively connected to the drive screw and rotatable about the first axis. The 90 degree gearbox preferably also has a second output member which is rotatable about a second axis perpendicular to the first axis. The 90 degree gearbox can comprise a series of bevel gears.
Type:
Grant
Filed:
June 10, 1999
Date of Patent:
July 31, 2001
Assignee:
Atwood Industries, Inc.
Inventors:
John Scott Erickson, Damon Dirk Shaw, Bryce Joel Bulthaus
Abstract: A bladder for use as a cushioning element and footwear incorporating the bladder. The enclosed core is formed of spaced apart first and second fabric layers connected together by a plurality of connecting yarns. The shell is formed of see-through plastic material whereby the connecting yarns are visible through the sidewall. The plurality of connecting yarns preferably are arranged in bands with gaps devoid of connecting yarns between adjacent bands, and the ends of the bands and the gaps are visible through the sidewall.
Type:
Grant
Filed:
July 8, 1999
Date of Patent:
September 19, 2000
Assignee:
Nike, Inc.
Inventors:
David A. Goodwin, Richard M. Hogan, Steven D. Buchanan, Sr., Edward Nathaniel Thomas, Gary Allen Kokstis
Abstract: Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.
Type:
Grant
Filed:
September 9, 1996
Date of Patent:
November 24, 1998
Assignees:
MoGill University, Eastern Virginia Medical School of the Medicine College of Hampton Roads
Inventors:
Aaron I. Vinik, Gary L. Pittenger, Ronit Rafaeloff, Lawrence Rosenberg, William P. Duguid