Abstract: Method of inhibiting human rhinovirus (HRV) Infection by contacting said HRV with a polypeptide comprising a fragment of human rhinovirus major receptor (HRR), said fragment comprising the HRV binding site and being selected from a specific group consisting of HRR domains.
Type:
Grant
Filed:
September 30, 1994
Date of Patent:
November 7, 2006
Assignee:
Bayer Pharmaceuticals Corporation
Inventors:
Jeffrey M. Greve, Alan McClelland, Gary Davis
Abstract: This invention concerns conditional protoplasts of temperature-sensitive variants of the osmotic-1 mutant strain of Neurospora crassa, and method of making same.
Abstract: An organosulfur compound is detected and/or quantified, optionally in admixture with one or more other compounds, by reacting the organosulfur compound with gaseous fluorine at sub-atmospheric pressure and observing the chemiluminescence which develops. Detections at ultra-trace levels are achieved. A special detector cell is provided in which the reaction is performed.
Type:
Grant
Filed:
February 16, 1988
Date of Patent:
July 11, 1989
Assignee:
University Patents, Inc.
Inventors:
John W. Birks, Julie N. Getty, Richard H. Getty
Abstract: A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the body or externally on the body in a variety of medical uses.
Abstract: Specific DNA sequence insertions, deletions and substitutions (i.e., combinations of sequence deletion and insertion) in eukaryotic cell or viral genomes are stably effected through use of selectable DNA sequences comprising a herpesvirus thymidine kinase (tk) gene.
Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is a moiety selected from the group consisting of ##STR2## R.sub.2 -R.sub.22 are amino acid moieties wherein R.sub.2 is an optional moiety which when present is selected from the group consisting of Ser and Gly,R.sub.8 is Leu or Val,R.sub.10 is Gln, Lys, or Gly,R.sub.11, R.sub.14, and R.sub.20 are each independently selected from the group consisting of Gln and Lys,R.sub.12 is Leu or Trp,R.sub.13 is Gln or Ser,R.sub.17 is Gln or His,R.sub.19 is Leu or Cys,R.sub.21 is Gln or Thr,R.sub.22 is an optional moiety which when present is selected from the group consisting of Leu and Tyr;R.sub.24 -R.sub.
Abstract: A process for detecting the presence of trace amounts of non-fluorescent soluble compounds each having at least one labile hydrogen atom in a carrier solution by adding a non-fluorescent quinone which is reducible to a fluorescent hydroquinone, and irradiating the resulting solution in the absence of oxygen with light of sufficient energy to cause the quinone to be reduced to a hydroquinone. The invention further provides a novel photochemical reactor--recording fluorometer combination and carrier liquid--quinone solution for performing the analysis.
Abstract: A biogenic ice nucleation inhibitor, derivable from a source plant which is normally subjected to freezing stress in its natural habitat, is employed for protecting light frost-sensitive plants against frost injury by inhibiting the ice-nucleating activity of the ice-nucleating bacteria normally present on the plants, and thereby reducing the temperature at which frost injury occurs. The inhibitor is applied to the plants in the form of a solution of a water-soluble denaturable proteinaceous material derivable as a water extract of a source plant component which survives the freezing stress to which the source plant is normally subjected in its natural habitat, such as the seed. The inhibitor is also applicable for reducing the temperature at which ice formation occurs in any other medium containing active ice nucleation initiators, such as, for example, the atmosphere and concrete.
Abstract: Endogenous and exogenous gene directed expression of protein synthesis in Escherichia coli is enhanced by transformation to incorporate a dominant mucoid mutant allele of the capR (lon) gene, preferably through use of the DNA plasmid, pBZ201M9 (A.T.C.C. Plasmid No. 40041) which carries the capR9 mutant allele.
Type:
Grant
Filed:
August 17, 1983
Date of Patent:
May 20, 1986
Assignee:
University Patents, Inc.
Inventors:
Alvin Markovitz, Barbara A. Zehnbauer, Joyce M. Schoemaker, Marc F. Charette
Abstract: Hydrophilic biopolymeric copolyelectrolytes comprising (a) a water-soluble linear anionic protein polyelectrolyte component derived from keratin and (b) a water-soluble linear cationic biopolymer polyelectrolyte component derived from at least one biopolymer selected from the group consisting of collagen and a glucosaminoglycan. Hydrogel membranes formed from the copolyelectrolytes are useful as biodegradable dressings for denuded tissue wound sites.
Abstract: Compounds of the formula: ##STR1## wherein R.sub.1 is a moiety selected from the group consisting of ##STR2## R.sub.2 -R.sub.22 are amino acid moieties wherein R.sub.2 is an optional moiety which when present is selected from the group consisting of Ser and Gly,R.sub.8 is Leu, Val, or Ile,R.sub.10 is Gln, Lys, or Gly,R.sub.11, R.sub.14, and R.sub.20 are each independently selected from the group consisting of Gln and Lys,R.sub.12 is Leu or Trp,R.sub.13 is Gln or SerR.sub.17 is Gln or His,R.sub.21 is Gln or Thr,R.sub.
Abstract: A contraceptive agent is provided which comprises biologically-active alpha-lactalbumin. The agent can be administered to female mammals using a variety of pharmaceutically acceptable vehicles, provided the alpha-lactalbumin retains its biological activity in the presence of the vehicle.
Abstract: This invention relates to new polypeptide antibiotics designated LL-BO2964.alpha., LL-BO2964.beta., LL-BO2964.gamma., and a mixture thereof designated LL-BO2964, produced during microbiological fermentation, under controlled conditions, using a new strain of Streptomyces coeruleorubidus subspecies rubidus or a mutant thereof. The new antibiotics are active against a variety of microorganisms and are also useful in treating tuberculosis.
Type:
Grant
Filed:
March 25, 1982
Date of Patent:
February 12, 1985
Assignee:
American Cyanamid Company
Inventors:
May D. Lee, John H. Martin, Donald B. Borders, Raymond C. Yao, Raymond T. Testa
Abstract: A synthetic polymeric ice nucleation inhibitor is employed for protecting light frost-sensitive plants against frost injury by inhibiting the ice-nucleating activity of the ice-nucleating bacteria normally present on the plants, and thereby reducing the temperature at which frost injury occurs. The inhibitor is applied to the plants in the form of a solution of a synthetic polymer having covalently bound to its main backbone chain both pendant hydrophobic groups and pendant hydrophilic groups. The ratio of and average intermolecular spacing between the hydrophobic groups and the hydrophilic groups in the polymer, and the molecular weight of the polymer, are selected so that in combination they provide the polymer with a limited room temperature water solubility within the range of from about 1 .mu.g/ml to about 100 mg/ml.
Abstract: A chromatographic procedure for the purification of a proteolytic procoagulant enzyme from extracts of human and animal tumors. The extracts are sequentially contacted with a first benzamide affinity chromatographic resin, an agarose filtration gel, a second benzamide affinity chromatographic resin and a phenyl-sepharose hydrophobic chromatographic resin. The resulting enzyme is capable of producing anti-procoagulant antibody which, which used in an immunoassay, is diagnostic for malignancy.