Patents Represented by Attorney Barbara G. McClung
-
Patent number: 8173150Abstract: This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×10?7 reciprocal second.Type: GrantFiled: March 8, 2011Date of Patent: May 8, 2012Assignee: Intarcia Therapeutics, Inc.Inventors: Stephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
-
Patent number: 8158150Abstract: An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.Type: GrantFiled: August 12, 2011Date of Patent: April 17, 2012Assignee: Intarcia Therapeutics, Inc.Inventors: Scott D. Lautenbach, Pedro E. de la Serna, Pauline C. Zamora, Michael A. DesJardin
-
Patent number: 7407499Abstract: An osmotic pump includes a capsule having at least one delivery port formed at a first end and a membrane plug retained in a second end of the capsule remote from the delivery port to provide a fluid-permeable barrier between an interior and an exterior of the capsule. The membrane plug has a columnar body and at least one slot formed in the columnar body to vent pressure from the interior to the exterior of the capsule when the columnar body extends a predetermined distance relative to the second end of the capsule, thereby preventing expulsion of the membrane plug from the second end.Type: GrantFiled: October 20, 2004Date of Patent: August 5, 2008Assignee: Intarcia Therapeutics, Inc.Inventor: Joseph C. Trautman
-
Patent number: 6941163Abstract: The present invention relates to methods of formulating analyte data databases, the databases themselves, and methods of manipulating the same. In one aspect the present invention includes the formulation of analyte data points, derived data, and data attributes databases comprising data points collected using an analyte monitoring device capable of frequent monitoring of analyte concentrations or amounts. Such data points may comprise acquired data (e.g., values corresponding to analyte concentrations or amounts as measured by said analyte monitoring device). These data points are then associated with one or more relevant data attributes. The resulting databases may be manipulated to determine relationships among the components of the database.Type: GrantFiled: June 12, 2003Date of Patent: September 6, 2005Assignee: Cygnus, Inc.Inventors: Russell Ford, Matthew J. Lesho, Russell O. Potts, Michael J. Tierney, Charles W. Wei
-
Patent number: 6902905Abstract: This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.Type: GrantFiled: May 14, 2003Date of Patent: June 7, 2005Assignee: Cygnus, Inc.Inventors: Kim K. Burson, Michelle Van Wyhe, Jeffrey Pudlo, Michael Reidy, Pravin Soni, Christopher Uhegbu, Prema Vijayakumar
-
Patent number: 6885883Abstract: The present invention relates to a predictive-kinetic method for use with data processing of a sensor-generated signal, as well as, microprocessors and monitoring systems employing such a predictive-kinetic method. Data from a transient region of a signal is used with suitable models and curve-fitting methods to predict the signal that would be measured for the system at the completion of the reaction. The values resulting from data processing of sensor response using the methods of the present invention are less sensitive to measurement variables.Type: GrantFiled: May 14, 2001Date of Patent: April 26, 2005Assignee: Cygnus, Inc.Inventors: Norman A. Parris, Russell O. Potts, Michael J. Tierney, Christopher Uhegbu
-
Patent number: 6882940Abstract: Described herein are methods, devices, and microprocessors useful for predicting a hypoglycemic event in a subject. The hypoglycemic predictive approach described herein utilizes information obtained from a data stream, e.g., frequently obtained glucose values (current and/or predicted), body temperature, and/or skin conductance, to predict incipient hypoglycemic events and to alert the user.Type: GrantFiled: August 10, 2001Date of Patent: April 19, 2005Assignee: Cygnus, Inc.Inventors: Russell O. Potts, Michael J. Tierney
-
Patent number: 6862466Abstract: Methods of frequently monitoring glucose amounts and/or concentrations in a subject who is at risk for hypoglycemia, hyperglycemia, and/or glucose level fluctuations that put the subject at risk are provided. Also provided are methods of monitoring the effects of one or more pharmaceutical compositions on the levels of glucose in a subject.Type: GrantFiled: April 23, 2003Date of Patent: March 1, 2005Assignee: Cygnus, Inc.Inventor: Neil Ackerman
-
Patent number: 6850790Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.Type: GrantFiled: May 14, 2003Date of Patent: February 1, 2005Assignee: Cygnus, Inc.Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
-
Patent number: 6816742Abstract: An automated system for continual transdermal extraction of analytes present in a biological system is provided. The system can be used for detecting and/or measuring the concentration of the analyte using an electrochemical biosensor detection means. The system optionally uses reverse iontophoresis to carry out the continual transdermal extraction of the analytes.Type: GrantFiled: February 13, 2004Date of Patent: November 9, 2004Assignee: Cygnus, Inc.Inventors: Lynn Kim, Norman A. Parris, Russell O. Potts, Janet Tamada, Michael J. Tierney, Bret Berner
-
Patent number: 6771995Abstract: A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration of the mask is such that the mask prevents substantially all chemical signal transport from the chemical signal source having a radial vector component relative to a plane of the mask and the catalytic face of the working electrode, thus allowing primarily only chemical signal transport that is substantially perpendicular to the place of the mask and the catalytic surface of the working electrode. By reducing or eliminating chemical signal radial transport toward the working electrode, the mask thus significantly reduces or eliminates edge effects. By substantially reducing edge effects created by radial transport of chemical signal, it is possible to obtain a more accurate measurement of the amount (e.g.Type: GrantFiled: December 20, 2002Date of Patent: August 3, 2004Assignee: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael Tierney
-
Patent number: 6736777Abstract: The present invention relates generally to a sensor for use in monitoring the amount or concentration of target chemical analytes present in a biological system. For example, the invention relates to a sensor for measuring the amount or concentration of one or more analytes in a transdermally extracted sample. In one embodiment, the invention includes a sensor element comprising, a sensing electrode that reacts electrochemically with hydrogen peroxide to provide a detectable signal, wherein the sensing electrode comprises a platinum-group metal.Type: GrantFiled: January 29, 2003Date of Patent: May 18, 2004Assignee: Cygnus, Inc.Inventors: Lynn Kim, Norman A. Parris, Russell O. Potts, Michael J. Tierney
-
Patent number: 6687522Abstract: A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the subject in a first direction in one or more sampling chambers that functions alternatively as both an anode and cathode during the course of the method; reversing the polarity to cause direct current to flow in second direction opposite the first direction; and analyzing the sampling chamber or chambers for the concentration of a substance or a substance metabolite. There is also provided a device for sampling of a substance from an organism on continuously or intermittently using alternating polarity method based on the application of low intensity electric fields of alternating polarity across the skin (iontophoresis) to enhance the transport of a substance (such as glucose, lactic acid, pyruvic acid, and the like) from body tissues to a sampling chamber.Type: GrantFiled: June 28, 2001Date of Patent: February 3, 2004Assignee: Cygnus, Inc.Inventor: Janet Tamada
-
Patent number: 6653091Abstract: The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a monitoring system and a Mixtures of Experts (MOE) algorithm. In one embodiment, the present invention describes a method for measuring blood glucose in a subject.Type: GrantFiled: July 23, 2001Date of Patent: November 25, 2003Assignee: Cyngnus, Inc.Inventors: Timothy C. Dunn, Yalia Jayalakshmi, Ronald T. Kurnik, Matthew J. Lesho, Jonathan James Oliver, Russell O. Potts, Janet A. Tamada, Steven Richard Waterhouse, Charles W. Wei
-
Patent number: 6615078Abstract: This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.Type: GrantFiled: April 21, 2000Date of Patent: September 2, 2003Assignee: Cygnus, Inc.Inventors: Kim K. Burson, Michelle Van Wyhe, Jeffrey Pudlo, Michael Reidy, Pravin Soni, Christopher Uhegbu, Prema Vijayakumar
-
Patent number: 6595919Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.Type: GrantFiled: February 27, 2001Date of Patent: July 22, 2003Assignee: Cygnus, Inc.Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
-
Patent number: 6594514Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.Type: GrantFiled: December 20, 2001Date of Patent: July 15, 2003Assignee: Cygnus, Inc.Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
-
Patent number: 6561978Abstract: Devices and methods are provided for frequently measuring the concentration of an analyte present in a biological system. A monitoring system having at least two components is employed in order to allow separation of data collection from data processing and display. Such separation allows greater flexibility and convenience for the user.Type: GrantFiled: February 11, 2000Date of Patent: May 13, 2003Assignee: Cygnus, Inc.Inventors: Thomas E. Conn, Russell Ford, Russell O. Potts, Pravin L. Soni, Janet A. Tamada, Michael J. Tierney
-
Patent number: RE38681Abstract: An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.Type: GrantFiled: December 2, 2002Date of Patent: January 4, 2005Assignee: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael J. Tierney
-
Patent number: RE38775Abstract: An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.Type: GrantFiled: October 30, 2002Date of Patent: August 16, 2005Assignee: Cygnus, Inc.Inventors: Ronald T. Kurnik, Janet Tamada, Michael J. Tierney