Patents Represented by Attorney Barbara L. Cowley

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  • N-Carbomethoxy-N'-[2'-nitro-4'-propyloxyphenyl]-S-methyl-isothiourea and method of use thereof
    Patent number: 4207333
    Abstract: The compound, N-carbomethoxy-N'-[2'-nitro-4'-propyloxyphenyl]-S-methyl-isothiourea, is useful in the treatment of helminth infestation in ruminants.
    Type: Grant
    Filed: November 15, 1978
    Date of Patent: June 10, 1980
    Assignee: Schering Corporation
    Inventor: Mohammed M. Nafissi-Varchei
  • Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio)alkanoic acids and compounds related thereto
    Patent number: 4199597
    Abstract: Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with an alkyl ester of a bromoalkanoic acid, followed by hydrolysis to the free acid.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: April 22, 1980
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • 1-Benzhydryl-2-benzimidoyl-azetidine
    Patent number: 4196124
    Abstract: 1-Benzhydryl-2-benzimidoyl-azetidine, an intermediate useful in the preparation of novel N-diphenylalkyl-2-benzyl azacyclic compounds which can be used as antiobesity agents, is disclosed.
    Type: Grant
    Filed: November 20, 1978
    Date of Patent: April 1, 1980
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • Antipsoriatic compositions
    Patent number: 4183923
    Abstract: Disclosed herein are compositions containing 1-substituted-3-alkanesulfonyloxyazetidines, useful in the treatment of psoriasis.
    Type: Grant
    Filed: November 7, 1977
    Date of Patent: January 15, 1980
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]thiazolin-4-ones
    Patent number: 4176120
    Abstract: 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and the thiazolin-4-ones corresponding thereto, having useful anti-hypertensive properties, are disclosed herein. The compounds are prepared by reaction of the appropriate 4-(polyhalo-2-hydroxy-2-propyl)aniline with a .beta.-chloroethanoyl isocyanate or isothiocyanate and then cyclization of the resultant intermediate.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 27, 1979
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Nicola Zampaglione
  • 1-Benzhydryl-2-cyanoazetidine
    Patent number: 4173566
    Abstract: 1-benzhydryl-2-cyanoazetidine is a novel intermediate for the synthesis of N-diphenylalkyl-2-benzyl azacyclic compounds.
    Type: Grant
    Filed: August 23, 1978
    Date of Patent: November 6, 1979
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • Diastereoisomers of 5-(1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide
    Patent number: 4173583
    Abstract: Disclosed is an improved process for separating 5-[1-hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl]salicylamide into its two diastereoisomeric racemates; a process for converting either diastereoisomer into the other; and the use of one specified diastereoisomer as a superior antiarrhythmic agent.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: November 6, 1979
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Wei Chang
  • Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
    Patent number: 4163053
    Abstract: 5-[2-(Substituted-anilinoalkylamino)-1-hydroxyalkyl]-salicylamides, particularly useful as agents for the treatment of hypertension, are disclosed herein.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: July 31, 1979
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Substituted anilino-2-thiazolines
    Patent number: 4159335
    Abstract: Novel para-polyfluoroisopropyl-anilino-2-oxazolines and thiazolines are provided which exhibit potent antihypertensive properties without significant CNS depression.
    Type: Grant
    Filed: January 25, 1978
    Date of Patent: June 26, 1979
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Pharmaceutical compositions comprising N-diphenylalkyl-2-benzyl azacyclic compounds and methods for their use
    Patent number: 4140780
    Abstract: N-diphenylalkyl-2-benzyl azacyclic compounds and pharmaceutical compositions thereof which are useful as antiobesity agents are disclosed herein. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this series are provided.
    Type: Grant
    Filed: July 28, 1977
    Date of Patent: February 20, 1979
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and thiazolin-4-ones corresponding thereto
    Patent number: 4103018
    Abstract: 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and the thiazolin-4-ones corresponding thereto, having useful anti-hypertensive properties, are disclosed herein. The compounds are prepared by reaction of the appropriate 4-(polyhalo-2-hydroxy-2-propyl)aniline with a .beta.-chloroethanoyl isocyanate or isothiocyanate and then cyclization of the resultant intermediate.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: July 25, 1978
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Nicola Zampaglione
  • Anti-hypertensive polyhaloisopropyl-substituted arylureas
    Patent number: 4093742
    Abstract: Novel polyhaloisopropyl-substituted arylureas having potent antihypertensive properties are disclosed herein.
    Type: Grant
    Filed: May 4, 1976
    Date of Patent: June 6, 1978
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Methyl-6-n-propoxybenzothiazole-2-carbamate and anthelmintic pharmaceutical compositions thereof
    Patent number: 4093731
    Abstract: The title compound is a novel substance which effectively treats helminthiasis.
    Type: Grant
    Filed: March 7, 1977
    Date of Patent: June 6, 1978
    Assignee: Schering Corporation
    Inventor: Mohammed Mehdi Nafissi-Varchei
  • Process for the preparation of tertiary amines
    Patent number: 4086234
    Abstract: Certain tertiary amines useful as pharmaceuticals are prepared in improved yields by condensing a cyclic secondary amine with a primary alkyl halide in an aqueous medium in the presence of an acid acceptor.
    Type: Grant
    Filed: November 7, 1975
    Date of Patent: April 25, 1978
    Assignee: G. D. Searle & Co.
    Inventors: Hugh Latimer Dryden, Jr., Robert A. Erickson
  • Steroid ointment
    Patent number: 4070462
    Abstract: An improved ointment for the topical administration of steroids is comprised of a therapeutically effective amount of a 17-mono or 17,21-diester of betamethasone in a non-aqueous base comprised of 5-15% of a glycol solvent, 1-3% of a principle emulsifying agent; 0-7% of a secondary emulsifying agent; and 70-90% of a petrolatum base.
    Type: Grant
    Filed: October 26, 1976
    Date of Patent: January 24, 1978
    Assignee: Schering Corporation
    Inventor: Varda Ecker
  • 2-Aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole
    Patent number: 4070369
    Abstract: Disclosed herein is the novel compound, 2-aminomethyl-5-chloro-3-(2,4-dichlorophenyl)indole, useful by virtue of its antimicrobial, sanitizing, disinfectant, preservative, viricidal and herbicidal properties.
    Type: Grant
    Filed: August 18, 1976
    Date of Patent: January 24, 1978
    Assignee: Schering Corporation
    Inventor: Martin Steinman
  • 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl}heptanoic acids and esters
    Patent number: 4060691
    Abstract: 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl{heptanoic acids and esters, displaying valuable pharmacological properties, e.g., gastric anti-secretory, are produced by the reaction of a 7-(3-oxygenated-5-oxocyclopent-1-en-1-yl)heptanoic acid or ester with the appropriate organometallic reagent.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: November 29, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Paul W. Collins, Raphael Pappo
  • 6-(Polyhaloisopropyl)quinazoline-2,4-diones
    Patent number: 4058612
    Abstract: Novel 6-(polyhaloisopropyl)quinazoline-2,4-diones, preparable from polyhaloisopropylarylureas, are disclosed herein. These compounds display potent hypotensive activity and are thus useful in the treatment of mammalian hypertension.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: November 15, 1977
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • N-diphenylalkyl-2-benzyl azacyclic compounds
    Patent number: 4052383
    Abstract: Novel N-diphenylalkyl-2-benzyl azacyclic compounds are disclosed which can be used as antiobesity agents. Some of these compounds also exhibit useful antimicrobial properties. Additionally, novel chemical intermediates for the synthesis of this series are provided.
    Type: Grant
    Filed: March 8, 1976
    Date of Patent: October 4, 1977
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Daniel M. Solomon
  • Serologic test for systemic candidiasis
    Patent number: 4051232
    Abstract: An in vitro test method for the diagnosis of systemic candidiasis in mammals is carried out with an antigen solution containing a specified concentration and ratio of protein antigen and mannan antigen whereby false readings are reduced.
    Type: Grant
    Filed: August 12, 1975
    Date of Patent: September 27, 1977
    Assignee: Schering Corporation
    Inventors: Walter P. Protzman, George L. Evans