Abstract: A method is provided for inactivating viral and/or bacterial contamination in blood cellular matter, such as erythrocytes and platelets, or protein fractions. The cells or protein fractions are mixed with chemical sensitizers, frozen or freeze-dried, and irradiated with, for example, UV, visible, gamma or X-ray radiation while in the solid state.
Type:
Grant
Filed:
April 14, 1993
Date of Patent:
February 13, 2001
Assignee:
Baxter International Inc.
Inventors:
Matthew S. Platz, Raymond P. Goodrich, Jr., Nagender Yerram
Abstract: Viral, bacterial and parasitic contaminants in blood and cell culture containing compositions are inactivated by adding a photosensitizer and a blocking agent to the composition and irradiating the resulting mixture with electromagnetic radiation. Blocking agents reduce photolysis of the photosensitizer by mechanisms not involving the quenching of reactive oxygen species. The blocking agents reduce photolysis which occurs by ring opening. Preferred photosensitizers are quinoline or quinolone.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
September 21, 1999
Assignee:
Baxter International Inc.
Inventors:
Samuel O. Sowemimo-Coker, Nagender Yerram, Raymond P. Goodrich, Jr., Matthew S. Platz
Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
Type:
Grant
Filed:
June 5, 1995
Date of Patent:
February 9, 1999
Assignee:
Baxter International Inc.
Inventors:
Sang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila
Abstract: Viral and bacterial contaminants present in biological solutions are inactivated by mixing one of a novel class of photosensitizer with said solution and irradiating the mixture.
Type:
Grant
Filed:
April 21, 1995
Date of Patent:
August 4, 1998
Assignee:
Baxter International Inc.
Inventors:
Sang Chul Park, Raymond P. Goodrich, Jr., Nagender Yerram, Samuel O. Sowemimo-Coker, Matthew S. Platz, Brian M. Aquila