Patents Represented by Attorney, Agent or Law Firm Barry L. Copeland
  • Pyranoindoles for treating glaucoma
    Patent number: 7012090
    Abstract: Substituted pyranoindoles useful for lowering and controlling IOP and glaucoma are disclosed.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: March 14, 2006
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Hwang-Hsing Chen
  • Use of a mixture of sodium hyaluronate and chondroitin sulfate for the treatment of osteoarthritis
    Patent number: 6949525
    Abstract: This invention is related to the use of the composition formed by sodium hyaluronate and sodium chondroitin sulfate for the treatment of chondral lesions in osteoarthritis, and to the use of such composition in the manufacture of a product for such treatment.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: September 27, 2005
    Assignee: Alcon, Inc.
    Inventor: Elias Humberto Ochoa Hermida
  • Regeneration of articular cartilage damaged by grade I and II osteoarthritis by means of the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate in a gel vehicle
    Patent number: 6906044
    Abstract: Methods of treating osteochondral lesions by the intraarticular application of a mixture of sodium hyaluronate and chondroitin sulfate are disclosed.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: June 14, 2005
    Assignee: Alcon, Inc.
    Inventor: Elias Humberto Hermida Ochoa
  • Process for use in 11-oxa prostaglandin synthesis
    Patent number: 6828444
    Abstract: Novel processes useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: December 7, 2004
    Assignee: Alcon, Inc.
    Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
  • 5-Hydroxyl indole derivatives for treating glaucoma
    Patent number: 6806285
    Abstract: Novel 3-(2-aminopropyl)-H-indol-5-ols useful for lowering and controlling IOP and treating glaucoma are disclosed.
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: October 19, 2004
    Assignee: Alcon, Inc.
    Inventors: Jesse A. May, Paul W. Zinke
  • Use of cloprostenol and fluprostenol analogues to treat glaucoma and ocular hypertension
    Patent number: 6723748
    Abstract: Disclosed is the use of cloprostenol and fluprostenol analogues in combination with carbonic anhydrase inhibitors for the treatment of glaucoma and ocular hypertension and ophthalmic compositions therefor.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: April 20, 2004
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Peter G. Klimko, John E. Bishop, Verney L. Sallee, Paul W. Zinke
  • 15-fluoro prostaglandins as ocular hypotensives
    Patent number: 6680339
    Abstract: 15-fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: January 20, 2004
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, Paul W. Zinke
  • 11&bgr;-fluoro 15&bgr;-hydroxy PGF2&agr; analogs as FP receptor antagonists
    Patent number: 6649655
    Abstract: Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: November 18, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Najam A. Sharif, Brenda W. Griffin
  • 15-fluoro prostaglandins as ocular hypotensives
    Patent number: 6649653
    Abstract: 15-Fluoro substituted analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: November 18, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Peter G. Klimko, Mark R. Hellberg, Paul W. Zinke
  • Lipoxin A4 and its analogs for the treatment of dry eye
    Patent number: 6645978
    Abstract: Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: November 11, 2003
    Assignee: Alcon, Inc.
    Inventors: Daniel A. Gamache, Gustav Graff, Mark R. Hellberg, Peter G. Klimko, John M. Yanni
  • Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension
    Patent number: 6646001
    Abstract: Disclosed are methods and compositions for the treatment of glaucoma and ocular hypertension, comprising the administration of a prostaglandin FP receptor agonist and a prostaglandin synthesis inhibitor.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: November 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Mark R. Hellberg, Jon C. Nixon
  • Compounds for use in 11-oxa prostaglandin synthesis
    Patent number: 6620947
    Abstract: Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
    Type: Grant
    Filed: August 26, 2002
    Date of Patent: September 16, 2003
    Assignee: Alcon, Inc.
    Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
  • 6-Keto prostaglandin F1&agr; and analogs for treating dry eye
    Patent number: 6576663
    Abstract: Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF1&agr; and its analogs are disclosed.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: June 10, 2003
    Assignee: Alcon, Inc.
    Inventor: Peter G. Klimko
  • Method of prostaglandin synthesis
    Patent number: 6531614
    Abstract: Methods of synthesizing 9-Halo-13,14-dihydroprostaglandins useful in the treatment of glaucoma and ocular hypertension are disclosed. Also disclosed are ophthalmic, pharmaceutical compositions comprising such prostaglandins.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: March 11, 2003
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Raymond E. Conrow
  • Methods of performing surgery with galactomannan polymers and borate
    Patent number: 6495608
    Abstract: The present invention is directed to viscoelastic systems comprising a combination of a galactomannan polysaccharide containing composition and borate containing composition. The two compositions gel or partially gel upon combination. The present invention also discloses methods of using the systems during surgery and, in particular, eye surgery.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: December 17, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Bahram Asgharian
  • 11-deoxy-16-fluoro-PGF2&agr; analogs as FP receptor antagonists
    Patent number: 6492417
    Abstract: Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: December 10, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Najam A. Sharif, Brenda W. Griffin
  • Prostaglandin E receptor agonists for treatment of dry eye
    Patent number: 6462080
    Abstract: The present invention relates to use of prostaglandin E receptor agonists and partial agonists to stimulate mucin secretion to treat dry eye, keratoconjunctivitis, Sjogren's syndrome and related ocular surface diseases.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: October 8, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventor: Peter G. Klimko
  • Processes and novel intermediates for 11-oxa prostaglandin synthesis
    Patent number: 6441196
    Abstract: Novel processes and intermediates useful in the preparation of 11-oxa prostaglandin analogs are disclosed.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: August 27, 2002
    Assignee: Alcon, Inc.
    Inventors: Pete Delgado, Raymond E. Conrow, William D. Dean, Michael S. Gaines
  • 11&bgr;-fluoro 15&bgr;-hydroxy PGF2&agr; analogs as FP receptor antagonists
    Patent number: 6441033
    Abstract: Methods and compositions for the antagonism of FP receptor-mediated biological responses are disclosed.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: August 27, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Najam A. Sharif, Brenda W. Griffin
  • 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
    Patent number: 6417228
    Abstract: 13-Aza analogs of PGF2&agr; and methods of their use in treating glaucoma and ocular hypertension are disclosed.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: July 9, 2002
    Assignee: Alcon Manufacturing, Ltd..
    Inventor: Peter G. Klimko