Abstract: The present invention provides an integrated method, implemented over a wide area network or wireless network, comprising a server side and a client side, for user-directed acquisition of reference information, such as dictionary definitions (“look-ups”) or language translation, relating to user-selected messages or user-selected text of World Wide Web (Web”) site pages. The method steps, for Web use, are integrated into either a server-side web site or into a client-side system. In particular embodiments, reference information relating to user-selected Web page includes high quality multi-lingual translations, explanations, illustration and/or consolidated automatic multi-dictionary definitions, wherein such information is displayed to the user in text, voice, image or multi-media formats. The present invention also provides an apparatus for user-directed acquisition of information relating to user-selected Web page text.

Abstract: There is disclosed a cancer diagnostic method based upon DNA methylation differences at specific CpG sites. Specifically, the inventive method provides for a bisulfite treatment of DNA, followed by methylation-sensitive single nucleotide primer extension (Ms-SNuPE), for determination of strand-specific methylation status at cytosine residues.

Abstract: A method of manufacturing disposable tableware products is taught using a degradable composite material including the following components by weight in parts: a plant fiber, 60-90 parts; a urea-formaldehyde resin, 10-35 parts; a melamine resin, 3-10 parts; and a food coloring agent, 1-10 parts; wherein the molecular weight of said urea-formaldehyde resin is 300-600, including: (1) pulverizing the plant fiber into 60 mesh or over and thoroughly mixing the plant fiber with the urea-formaldehyde resin and the melamine resin proportionately to form a mixture of the degradable composite material; (2) feeding the mixture of the degradable composite material into a concave molding mould positioned in an operating platform of a hydraulic press wherein the press is capable of moving in an upward direction in a fixed quantity and position; maintaining the temperature of the mould at 125-190° C.

Abstract: The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleotide rich fragments affixed on a screening array. Positive hybridization signals indicate the presence of methylated sites. Methods of preparing the hybridization probes and screening array are also provided.

Abstract: There is disclosed an initial identification of an N-terminally truncated HER-2/neu product. This product is a 95 kDa polypeptide having in vitro kinase activity (as determined by western blotting). Moreover, immunoprecipitations using domain specific antibodies was able to utilize this specific polypeptide from intracellular fragments as a diagnostic and prognostic indicator of adenomacarcinomas without the severe dilution effects encountered by measuring ECD.

Abstract: There is disclosed a sterilizing fog, characterized by droplet size range, vapor density range, sterilant concentration range and sterilant concentration within the droplets. Specifically, there is disclosed a fog achieved by an apparatus combining pressure, temperature and acoustics to form a super-charged ozoneated water and an apparatus that creates small micro droplets which form a highly concentrated sterilizing fog. Specific sterilants used are ozone, chlorine and chlorous acid generating compositions such as sodium hypochlorite, or combinations thereof.

Abstract: A roof ridge ventilator with filtering device to be installed under a cap shingle includes a one piece cover member of an elongated shape including a pair of flaps, each flap having one upper surface over which cap shingles are secured and also having downwardly facing lower surfaces, a pair of vents respectively secured to the lower surface of the cover member flaps, each vent including at least one set of shielded louvers having openings for deflecting air flow while maintaining a minimum free area for air passage such that the air flowing therethrough is substantially reduced in velocity to limit the infiltration of foreign matter. Longitudinally spaced supports extend substantially vertically to permit nailing onto the roof such that the vent does not collapse during installation and such that the net free area remains intact. A band of fibrous material positioned inboard of the vent to further prevent foreign matter for entering the attic.

Abstract: The present invention provides an air filtration device attachable to a motor. The device comprises a housing comprising an upper part and a lower part, wherein the upper and lower parts are parallel and spaced apart from each other and define a cavity therebetween, and wherein the lower part has a centrally positioned opening therein; an impeller positioned coaxially with the axis of the housing between the upper and lower parts thereof and attached to the motor; and a filter positioned between the upper and lower parts and positioned around a perimeter of the housing.

Abstract: A system and method for generation, graphical composition, and delivery (or routing for delivery) of conventional forms of written correspondence is disclosed. Specifically, the conventional form of written correspondence (e.g., business letter) contains integrated graphical correspondence content, and is generated from a correspondence message, such as a text Internet email message. More specifically, a sender can initiate correspondence in a variety of formats, to multiple recipients or to group(s) of recipients, wherein there is security provided against unauthorized generation of correspondence by assumed SMTP email identities, thereby preventing “forgery” of a correspondence from the sender.

Abstract: A system and method for generation, graphical composition, and delivery (or routing for delivery) of conventional forms of written correspondence. Specifically, the conventional form of written correspondence (i.e., business letter) is generated from a text Internet email message. More specifically, a sender can initiate correspondence in a variety of formats, to multiple recipients or to group(s) of recipients, wherein there is security provided against unauthorized generation of correspondence by assumed SMTP email identities, thereby preventing “forgery” of a correspondence from the sender.

Abstract: There is disclosed a a pharmaceutical composition for treating solid tumors that overexpress HER-2, comprising an agent selected from the group consisting of (a) an isolated polypeptide having from about 50 to 79 amino acids taken from the sequence of SEQ ID NO. 1, wherein the polypeptide binds to the extracellular domain ECD of HER-2 at an affinity of at least 108, (b) an isolated and glycosylated polypeptide having from about 300 to 419 amino acids taken from the sequence of SEQ ID NO. 2, wherein the C terminal 79 amino acids are present, and wherein at least three N-linked glycosylation sites are present, (c) a monoclonal antibody that binds to the ECD of HER-2, and (d) combinations thereof, with the proviso that the agent cannot be the monoclonal antibody alone, and pharmaceutically acceptable carrier.

Abstract: There is disclosed a sterilizing fog, characterized by droplet size range, vapor density range, sterilant concentration range and sterilant concentration within the droplets. Specifically, there is disclosed a fog achieved by an apparatus combining pressure, temperature and acoustics to form a super-charged ozoneated water and an apparatus that creates small micro droplets which form a highly concentrated sterilizing fog. Specific sterilants used are ozone, chlorine and chlorous acid generating compositions such as sodium hypochlorite, or combinations thereof.

Abstract: There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite to create methylation-dependent sequence differences, followed by detection with fluorescence-based quantitative PCR techniques. The process is particularly well suited for the rapid analysis of a large number of nucleic acid samples, such as those from collections of tumor tissues.