Abstract: The present invention relates to agonists of the human bitter-taste receptors hTAS2R46, hTAS2R47 and hTAS2R50 and their role in bitter taste transduction. The invention also relates to methods for identifying molecules that modulate, e.g. suppress, or enhance hTAS2R46, hTAS2R47 and hTAS2R50 bitter taste transduction or bitter taste response.

Abstract: A compounding process is disclosed. The process includes (i) melt blending in an extruder at least two polymeric resins to produce a mixture that includes at least one resin that dissociates to yield monomers and/or oligomers upon heating, said mixture containing less than 1 percent of volatile components, (ii) introducing into said extruder an inert entraining agent, and (iii) removing said entraining agent together with said volatile components from said extruder. The extruder includes at least one melting zone, at least two degassing zones and at least one mixing zone. The end product has a particularly low content of residual solvent and at the same time a low content of monomers or oligomers.

Abstract: Process for preparing alkylhalosilanes are provided. The process involve reacting an alkyl halide with a solid body formed of silicon and a catalytic system.

Abstract: This invention is directed to single-component alkoxy silicon sealants and methods of making the sealants. The sealants are made from a masterbatch M that includes at least one organopolysiloxane A having terminal and/or pendant alkoxylated groups and at least one mineral filler B.

Abstract: A system for brokering business service requests in a computer network is disclosed. The system is operative to receive a request for information from a requester, transmit the request to a provider, and return a response to the requester. The broker typically comprises the following components. A requester-side processing stage operative to communicate with the requester; a provider-side processing stage operative to communicate with the provider; and a broking stage operative to exchange data between the requester-side processing stage and the provider-side processing stage. In operation of the business service broker, upon receipt of a request for a requester, the broking stage obtains data required to respond to the request by communicating with a provider through the provider-side processing stage. The brokering stage formulates a response and returns it to the requester through the requester-side processing stage. The mechanism by which the response is obtained is abstracted from the requester.

Abstract: Stackable, farinaceous based low-fat snack chips are produced from a thin chain link strip of dough blanks by baking the strip in an oven with the strip blanks supported and carried by a lower mold assembly. Alternatively, the strip may be partially baked and then fried with the strip blanks sandwiched between upper and lower molds to produce reduced fat stackable snack chips.

Abstract: Novel carboxamides of the formula (I) The present application is further directed toward a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms, and also novel intermediates and their preparation.

Abstract: The disclosure relates to novel cycloalkylphenyl-substituted cyclic ketoenols of the formula (I) in which J, X, Y, m and CKE are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the disclosure relates to selective herbicidal compositions comprising, firstly, the cycloalkylphenyl-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The disclosure furthermore relates to increasing the activity of crop protection compositions comprising compounds of the formula (I) by adding ammonium or phosphonium salts and, if appropriate, penetrants.

Abstract: A process for the production of impact-modified composition that contains polyalkylene terephthalate and polycarbonate resins is disclosed. The process includes (i) in a first step combining in the melt at 90 to 175° C. glycidyl ester with at least one member selected from the first group consisting of polyalkylene terephthalate and polycarbonate to obtain a molten mixture, said member in powder form, and (ii) in a subsequent step combining the molten mixture with at least one component selected from the second group consisting of polyalkylene terephthalate and polycarbonate to obtain a composition. The composition is characterized in high gloss value.

Abstract: The invention relates to a tumor-associated peptide with an amino acid sequence selected from the group consisting of SEQ ID NO. 1 to SEQ ID NO. 577 from the attached sequence protocol, the peptide being capable of binding to a molecule of the human major histocompatibilityg complex (MHC) class I. The invention further relates to the use of the peptides for preparation of a drug and for the treatment of tumor diseases and/or adenomatous diseases. Furthermore, a pharmaceutical composition is described comprising at least one of the peptides.

Abstract: The present invention relates to bi-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions:

Abstract: The invention relates to a work-hardened product, particularly a rolled, extruded or forged product, made of an alloy with the following composition (% by weight): Cu 3.8-4.3; Mg 1.25-1.45; Mn 0.2-0.5; Zn 0.4-1.3; Fe<0.15; Si<0.15; Zr?0.05; Ag<0.01, other elements <0.05 each and <0.15 total, remainder Al, treated by dissolution, quenching and cold strain-hardening, with a permanent deformation of between 0.5% and 15%, and preferably between 1.5% and 3.5%. Cold strain-hardening can be achieved by controlled tension and/or cold transformation, for example rolling, die forging or drawing. This cladded metal plate type product is a suitable element to be used as aircraft fuselage skin.

Abstract: The present invention relates to 2,5-di-substituted-4-pyridinyloxy-substituted-phenyl-amidine derivatives, notably to 2,5-dialkyl-4-pyridinyloxy-substituted-phenyl-amidine derivatives, of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions (I).

Abstract: The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against colorectal cancer.

Abstract: The present invention relates generally to a composite plate produced by an alternating stack of (n+1) flexible graphite foils and (n) perforated metal reinforcing foils with spurs (where n?2). The thicknesses of the flexible graphite foils used are preferably such that any 2 mm slice of thickness of the composite plate comprises at least 3 layers of flexible graphite, and has a graphite density per unit area of at least 2.34 kg/m2. For each perforated metal reinforcing foil, the spurs present on the foil generally have a height in relation to the surface of that foil that does not exceed about 1.3 times the thickness of the thinnest of the flexible graphite layers to which it is attached. A composite plate of the present invention enables the manufacture of gaskets that resist temperatures up to 550° C. under continuous service.

Abstract: A mixture, which comprises (A) thidiazuron (or thidiazuron and diuron), and (B) one or more compounds from the group of the N-phenylsulfonyl(het)arylamides, if appropriate also in salt form, of the formula below: in which R21 is cyclopropyl and R22 is H, R21 is cyclopropyl and R22 is 5-Cl, R21 is ethyl and R22 is H, R21 is isopropyl and R22 is 5-Cl or R21 is isopropyl and R22 is H; is suitable for use as a defoliant, in particular in crops of cotton.

Abstract: The invention relates to a single- or multi-layered food casing, made from a thermoplastic mixture which comprises at least one aliphatic polyamide and/or copolyamide, at least one or more synthetic water-soluble polymers and at least one organic and/or inorganic filler. The skin has a water vapor permeability, as determined according to DIN 53122, in the non-oriented, monoaxially or biaxially oriented state of 50 to 1500 g/m2·d. The food casing is particularly suitable for use as an artificial sausage casing, particularly for raw sausages.

Abstract: The present invention relates to compositions comprising silicone elastomers and antiseptics in homogeneous distribution, to processes for the preparation thereof and to uses thereof, for example, in medical articles.

Abstract: The present invention relates to novel suspension concentrates of certain agrochemically active compounds, to a process for preparing these formulations and to their use for applying the active comprised therein.

Abstract: The present invention relates to a process for preparing substituted pyrazolyl chlorides by chlorinating aldehydes of the formula (II) under free-radical conditions.