Abstract: An electrode for use in a reduced pressure region in a mass spectrometer whereby the electrode is subject to deposition of dielectric (non-conducting) substances thereon, which can cause unstable performance of the mass spectrometer. The surface portion of the electrode that is for providing an equipotential boundary of an electric field for influencing charged particles is made rough, in contrast to the prior art of providing a polished surface. The rough surface provides projections and cavities, which may have a regular or irregular occurrence, which it has been found significantly reduces the deposition of dielectric substances from the charged particles thereon. A preferred structure is for a rod electrode (42) to have a screw thread (44) formed thereon whereby the thread crests (43) along the rod electrode provide projections (43) and the thread roots (45) provide cavities.

Abstract: Methods for applying an RF field in a two-dimensional electrode structure include applying RF voltages to main electrodes and to compensation electrodes. The voltages on the compensation electrodes may be adjusted to be proportional to the voltages on the main electrodes. The adjustment(s) may be done to optimize the RF field for different modes of operation such as ion ejection and ion dissociation. For dissociation, a supplemental RF dipole may be applied, or two mutually orthogonal dipoles may be applied in phase quadrature to form a circularly polarized field. Electrode structures may include main trapping electrodes, one or more compensation electrodes, one or more ion exit apertures, and means for applying the various desired voltages.

Abstract: A pressure sensor made of a wafer with a pair of parallel silicon layers and a silicon oxide layer there between, comprises a vibrating microassembly formed as a silicon beam, which is arranged in a plane perpendicular to the silicon layers and fastened to a supporting base. A control devise is formed from a portion of one of the silicon layers and is driven by a signal of a predetermined frequency component, which under absolute vacuum conditions makes the microassembly to freely oscillate at a known frequency and amplitude relative to the supporting base within a cavity formed by removing the silicon oxide layer. An optical detection system detects deviations of the frequency and/or amplitude of oscillation of the microassembly from the known frequency and/or amplitude.

Abstract: A spectrophotometer having an optical system for directing a beam of substantially monochromatic excitation light to a liquid sample contained in a well (3) of a well plate for interaction with the sample for absorption or emission measurements to analyse the sample. The optical system includes two apertures (46, 28) for establishing a Kohler illumination region outside the well, that is an excitation beam region between conjugate images (18, 21) of the two apertures. This excitation beam region is then demagnified and imaged (10, 9) into the well (3). The invention provides for the shape of the Kohler illumination region to correspond to the shape of the well space so that all of the liquid sample is uniformly illuminated without the well obstructing any portion of the illuminating excitation beam of light.

Abstract: A dissolution system provides remote flow cells integrated into a manifold device. The manifold device communicates with liquid input and output lines associated with each flow cell, as well as fiber-optic input and output lines associated with each flow cell. Liquid samples are respectively drawn from dissolution vessels, optically-related measurements are taken, and the samples are thereafter returned their respective vessels. The manifold device can be adapted to receive probe-type instruments that incorporate the fiber-optics, wherein each probe-type instrument is associated with each flow cell. Alternatively, each corresponding pair of fiber-optic input and output lines are disposed in opposing, optically-aligned relation and probe-type instruments are not used. The gap between the ends of the opposing fiber-optic lines provides a light path across the corresponding flow cell.

Abstract: A mass spectrometer in which a substance is introduced into a plasma (28) which contains analyte ions as the plasma (28) is passing through an aperture (42), for example in a skimmer cone (40) between two vacuum regions (38) and (44) so that the substance interacts with the plasma (28) thereby reducing the concentration of interfering polyatomic or multicharged ions in the plasma by reactive or collisional interactions. The substance may be supplied via passage (60) having an outlet (63) in skimmer cone (40). The invention gives improved attenuation of interfering ions because the substance is supplied directly into the plasma (28) as it is substantially radially confined by aperture (42) and before an ion beam (58) is extracted. Alternatively or additionally a substance may be supplied directly into the plasma within aperture (36) in sampling cone (34).

Abstract: In some embodiments, a nuclear magnetic resonance (NMR) method comprises generating an indicator of an anticipated time-averaged power for a radio-frequency (RF) pulse set, and anticipatively adjusting a cooling supplied by a cryogenic cooling fluid to an RF coil according to the indicator of the anticipated time-averaged power. The cryogenic cooling adjustment may be performed using a cryogenic fluid heater and/or a mass flow controller disposed in the cryogenic fluid path. The time difference between the start of the cooling adjustment and the start of the RF pulse set is set to be equal to the difference in timescales between the cooling effect of the cooling adjustment and the heating effect of the RF pulse set on the RF coil.

Abstract: A visual perception of a colored site in an immunoassay device comprising a strip for enabling capillary migration of a fluid sample therealong, a labeled reagent disposed on the strip and formulated for suspension in the sample migrating therepast and a captive reagent immobilized on the strip in a path of sample migration and formulated to bind to is enhanced by changing a color of the strip to the color which is complimentary to the colored site.

Abstract: In a method for inhibiting space charge-related effects in an ion source, an electron beam is directed into a chamber to produce ions from sample material in the chamber. A voltage pulse is applied to the chamber to perturb an electron space charge present in the chamber. The ion source may be an electron impact ionization (EI) apparatus. The ion source may operated in conjunction with a mass spectrometry system.

Abstract: Methods and apparatus are provided for leak detection by the accumulation method. The apparatus includes a sealable chamber (10) configured to receive a test piece (12) that, while in the chamber, contains a trace gas, a trace gas permeable member (30) in gas communication with the chamber, and a trace gas sensor (20) in gas communication with the permeable member and configured to sense the trace gas that passed from the chamber through the permeable member. The permeable member may be quartz. The trace gas sensor may include an ion pump.

Abstract: The thermal performance and vacuum properties of a cryogenic NMR probe are improved when thermal control is implemented by conductive heat transfer to a cold head cooled by a heat exchanger to below the selected operating temperature. The heat load is manipulated by locating a heater to produce a more nearly constant heat load in conjunction with pulsed RF power and in one embodiment transferring such heater power through a common thermal path. In another embodiment, the heater power is conductively transferred directly to the heat exchanger.

Abstract: A sample container may include an open end, a closure member, a cap, and an RFID tag. The RFID tag may be positioned near the open end and includes a code uniquely identifying an analytical sample contained in the container structure. A sample handling apparatus may operate with one or more sample containers. The sample handling apparatus may include a robotic assembly for moving a sample probe device and a sample probe supported by a guide of the sample probe device. An RF transceiver antenna may be mounted to the guide for communicating with the RFID tag of the sample container. The sample probe device is moved into proximity with a sample container to read a code stored by an RFID tag attached to the sample container, whereby a sample contained in the sample container can be uniquely identified. The code can be associated with additional information relating to the identified sample.

Abstract: Scroll pumping apparatus includes a first scroll element and a second scroll element, a drive mechanism operatively coupled to the second scroll element for producing orbiting motion of the second scroll element relative to the first scroll element, and a synchronization device including a strip having connected, substantially flat sections, coupled between the first scroll element and the second scroll element. The synchronization device may have a generally square configuration.

Abstract: Vacuum pumping apparatus includes a pump frame, a stationary scroll element secured to the pump frame, the stationary scroll element including a stationary scroll blade, an orbiting scroll element including an orbiting scroll blade intermeshed with the stationary scroll blade, a motor secured to the pump frame, and a crankshaft coupled between the motor and the orbiting scroll element for producing orbiting movement of the orbiting scroll blade relative to the stationary scroll blade when the motor is energized. The crankshaft includes a first component having a first coefficient of thermal expansion and a second component having a second coefficient of thermal expansion.

Abstract: In some embodiments, a tandem (MS/MS) mass spectrometry method includes selecting a collision-induced dissociation (CID) voltage amplitude and a q-parameter value for a quadrupole ion trap to optimize a daughter ion fragmentation process for a given parent ion mass-to-charge (m/z) ratio. The q and CID voltage values may be selected according to a look-up table and/or using approximate analytical expressions. The correspondence between m/z values and (q, CID) value pairs may be established by pre-measurement calibration. A fragmentation-optimized q value may be computed according to m/z, and a CID voltage value may be determined according to the computed q value. A user may also force q to another value, for example in order to facilitate trapping of a desired daughter ion mass range, and the controller computes a CID voltage value according to the forced q value.

Abstract: A molecular drag compressor includes a rotor disk coupled to a drive shaft for rotation about an axis, a stator disposed about the rotor disk, the stator defining a tangential flow channel, an inlet to the tangential flow channel and an outlet from the tangential flow channel, and a stationary baffle disposed in the tangential flow channel adjacent to the outlet. The baffle and the rotor disk have a gap between them. A surface of the baffle facing the rotor disk has cavities configured to produce turbulent gas flow through the gap between the baffle and the rotor disk and to thereby reduce leakage.

Abstract: A RF power generator for exciting inductively coupled plasma for spectrometry includes an induction coil for exciting the plasma as part of its load circuit. The load circuit also comprises a capacitor connected in parallel with the induction coil. The RF power generator is a free running oscillator having a switching circuit of two MOSFETs alternately switchable on and off via a feedback control circuit from the load circuit. RF power from the switching circuit is coupled to the load circuit via an inductor. The inductor and load circuit is resonant at a first frequency, which is lower than the operating frequency of the power generator.

Abstract: Enhanced nuclear polarization of a magnetic resonance sample provides greater detection sensitivity over conventional NMR spectroscopy due to a method and an apparatus of increasing the detection sensitivity. Molecules capable of forming photo-excited triplet states are combined in a solution with a NMR sample. While in a uniform magnetic field the solution is frozen, optical radiation is applied to produce photo-excited triplet states molecules and a microwave radiation is applied to stimulate transitions of one of the triplet lines producing dynamic polarization of the nuclei in the magnetic resonance sample. The frozen sample is then rapidly melted and a NMR analysis is performed.

Abstract: Methods and apparatus for large leak testing are provided. The apparatus includes a test line to receive a sample containing a trace gas, a mass spectrometer to detect the trace gas and having an inlet for receiving the trace gas, a first vacuum pump characterized by a relatively high reverse flow rate for light gases and a relatively low reverse flow rate for heavy gases, the first vacuum pump having a pump inlet and a foreline, the pump inlet being coupled to the inlet of the mass spectrometer, and a second vacuum pump configured to back the first vacuum pump. The apparatus further includes a trace gas permeable member coupled between the test line and the pump inlet, the foreline, or, in the case where the first vacuum pump is a turbomolecular pump, a midstage line.

Abstract: A vacuum pumping system includes a primary vacuum pump having an inlet for coupling to a system, and a secondary vacuum pump having an inlet coupled to the exhaust of the primary vacuum pump. The primary vacuum pump is an oil-free, positive displacement vacuum pump having multiple clearance seals between the inlet and the exhaust. The primary vacuum pump may be a scroll vacuum pump, and the secondary vacuum pump may be an oil-free diaphragm pump. The system may include a valve coupled to the exhaust of the primary vacuum pump and configured to couple the exhaust of the primary vacuum pump to an interpump exhaust in response to a selected condition, such as the pressure level at the exhaust of the primary vacuum pump.