Abstract: Provided herein are an electronic device, method and system for wireless communication over a wireless network. The device comprises an addressable point in network (Pin) which listens for all available wireless signals and creates and relays wireless signals containing destination address(es) for message(s) to other Pin(s). Wireless signal(s) are relayed from the Pin device(s) to other Pins over the network. Destination, receiving and originator Pin addresses and message flags within received messages are compared with message flags in a device memory trace queue to determine if the receiving Pin is the destination and/or origin of the message and whether the received message is retained and/or relayed or dropped. The system includes the Pin(s), a wireless communication network over which the message(s) are relayed to and from the Pin(s) and an enterprise provider information system (PIS) with an application stack configured to wirelessly transmit product and services information to the Pin(s).

Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Abstract: Provided herein are 1-aryl or 1-heteroaryl pyrido[b]indoles compounds with the structure These compounds comprise a ?-carboline ring structure substituted at C1 with an aryl or heteroaryl moiety and individually substituted at C3-C8 and N9 with a C1-C4 alkyl, a C1-C4 alkoxy, a C1-C4 alkoxyphenyl, or a hydrogen. Also provided are methods for inhibiting proliferation of cancer cells or for treating a cell proliferative disease by contacting the cancer cell or tumor comprising the same with the compounds provided herein or by administering the compounds to a subject with a cell proliferative disease.

Abstract: The present invention provides biomimetic contrast agents, dual functional contrast agents effective for therapeutic gene delivery and magnetic nanoparticles which comprise functionalized iron oxide nanoparticle cores, one of an inert gold layer, a layer of inert metal seeds or a silica layer and, optionally, one or both of an outer gold-silver nanoshell or a targeting ligand attached to the inert gold layer or the gold-silver nanoshell. Also provided are methods of in vivo magnetic resonance imaging, of treating primary or metastatic cancers or of ablating atherosclerotic plaque using the contrast agents and magnetic particles. In addition, kits comprising the biomimetic contrast agents, dual contrast agents and magnetic nanoparticles.

Abstract: The present invention describes a novel mechanism of adhesion by flagellated Gram-negative bacteria such as enterotoxigenic Escherichia coli (ETEC), where the bacteria secretes a protein, EtpA which binds to the conserved region of the flagellin protein located at the tip of the flagella. The present invention also discloses that EtpA-mediated interaction and intestinal colonization require interaction with flagellin. Also disclosed herein is a vaccine composition that can be used for either active or passive immunization of mammals for the prevention or treatment of infections caused by flagellated Gram-negative bacteria.

Abstract: Provided are methods and systems for distributing an asset to a multi-tiered network node. A pending notice is received from a distribution server. If the notice indicates that at least one asset is pending, i.e., awaiting deployment, an asset descriptor manifest is received from the distribution server. The asset descriptor manifest, which is stored in a memory on a node, identifies at least one asset to be deployed to the node and includes an offset associated with the asset identifier. A fragment, associated with the asset, is received and stored in the memory. The offset associated with the asset is marked with the end of the fragment and a second fragment, beginning at the offset, is received. Additional fragments are received, and the offset updated, until the entire asset is deployed to the node. Alternately, the entire asset or multiple assets are received in the first fragment.

Abstract: The present invention provides an emergency medical transportation vehicle comprising a two or three-wheeled motorcycle having a structural frame that encompasses a platform horizontally disposed along the wheel-base, where the platform has a front flat surface, and two rear surfaces extending from the front flat surface on either side of the rear wheel. The rear surfaces have sides extending vertically therefrom. The motorcycle carries the load of driver and patient, provides a safe, stable patient transportation, where passenger and rider are in one plane with the rider below and in complete view of the driver. The vehicle has a movable seat for the driver and chambers for placement of emergency medical equipment and supplies.

Abstract: Provided herein methods of screening for potential antidepressant compounds effective to increase production of cellular CDP-diacylglycerol and synthesis of inositol phospholipid in depression-related areas of the brain. Also, provided are methods of diagnosing and treating depressive or mood disorders in a subject by administering these screened antidepressant compounds. Further provided is a method of determining the therapeutic efficacy of an antidepressant drug regimen by comparing the ratio of CDP-diacylglycerol/inositol phosphate after treatment to a basal ratio in a subject.

Abstract: The present invention is directed to the examination of the pattern of immunodominant CD8 T cell epitopes in the E6 and E7 protein of Human Papillomavirus (HPV) and its further characterization in terms of its amino acid sequence and HLA restriction. These epitopes are identified based on their ability to induce strong CD8 T cell response and therefore, are important as sources of antigens for dendritic cell immunotherapy to treat cervical cancer. The present invention contemplates identifying a number of similar epitopes restricted by a wide variety of HLA types so that they can be used in concert to develop a preventative vaccine, which can be used for general population.

Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.

Abstract: The present invention provides devices for screening the skin of an individual in real time using a region-fusion based segmentation with narrow band graph partitioning algorithm to analyze and classify a region of interest of the skin as benign or malignant. Also, provided is a method for screening the skin of an individual using the devices described herein. In addition the present invention provides a digital processor-implemented system for classifying a region of interest on the skin and a processor readable medium having processor-executable instructions to perform skin cancer detection.

Abstract: Provided herein methods and structures for construction of light weight sandwich panels or load-bearing panels having improved ballistic protection. The methods disclosed can facilitate construction of a hybrid core comprising ballistic fabrics and deformable pins that exhibit superior resistance to ballistic penetration. The methods and structures of the present disclosures can be advantageously used in many applications, such as armored vehicles.

Abstract: The present invention discloses the protease stratum corneum chymotrytic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.

Abstract: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also provided are HLA gene-specific primers and HLA allele-specific or single nucleotide polymorphism-specific hybridization probes. In addition the present invention provides a microarray comprising the hybridization probes. Further provided is a kit comprising the HLA gene-specific primers and the microarray.

Abstract: The present invention provides a biomimetic contrast agent comprising an amine-functionalized iron (II) oxide/iron(III) oxide nanoparticle core a targeting ligand attached to the nanoparticle core via a linker and an inert outer layer of a hydrophilic polymer conjugated to the targeting ligand and imaging methods using the biomimetic contrast agents. Also, provided is a dual functional contrast agent comprising a metal-doped iron (II) oxide/iron(III) oxide nanoparticle core, an inert layer of gold coating the nanoparticle core and a biodegradable cationic polymer linked thereto. The dual functional contrast agent is complexed to a therapeutic gene and when transfected into mesenchymal stem cells comprises a dual contrast agent and gene delivery system. In addition, methods of using the dual functional system are provided. Furthermore, kits comprising the biomimetic contrast agents and the dual contrast agent and gene delivery system are provided.

Abstract: The instant invention provides a pelvic floor function diagnostic and therapeutic station, which includes a vaginal/ano-rectal plug and station. The important components of the station are a catheter holder with a pressure measuring (sleeve sensor or other alterative) to measure the constrictor function of the pelvic floor muscle, a vertical force transducer system to measure the elevator function of the pelvic floor muscle and a modular support table or a chair to hold the subject position. The diagnostic and therapeutic station thus allows for simultaneous measurement of the constrictor and elevator functions of the pelvic diaphragm. The station can also be used to treat impaired pelvic floor function via biofeedback therapy.

Abstract: A trophy cooler is provided, that is easy to transport and provides adequate separation of meat, skin and trophy-head while providing sufficient cooling. The trophy-cooler comprises a chamber comprising an inner wall of insulatory material. The trophy cooler further comprises one or more containers removably attached to an inner wall of the chamber. A removable lid is affixed to the top of the chamber, wherein said lid comprises means of opening one or more parts of the lid. A flexible sheet is removably affixed to the bottom of said lid, wherein said sheet comprises at least one slit.

Abstract: The present invention discloses the protease stratum corneum chymotryptic enzyme (SCCE) is specifically over-expressed in ovarian and other malignancies. A number of SCCE peptides can induce immune responses to SCCE, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies.

Abstract: The present invention provides a DNA encoding a TADG-14 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-14 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-14 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-14 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.