Abstract: The invention provides for inhibition of viral disease by the provision to a mammalian host of antibodies directed against an escort protein likeTsg 101. These proteins appear on the surface of a cell, and thus can be bound by circulating antibodies thereto. By binding escort proteins on the cell surface, budding of viral particles is inhibited. The virus infects the initial cells, but cannot escape that cell to infect the body en masse.

Abstract: The present invention provides methods and compositions for regulating ubiquitination in a cell. In particular, the present invention provides purified polypeptides comprising an ubiquitination-regulating domain. The invention also provides methods of using such polypeptides for screening for agents, for producing antibodies, and for treatment of diseases, e.g., proliferative diseases, neurodegenerative diseases, autoimmune diseases, metabolic disease and developmental abnormalities. The invention further provides antibodies that bind an ubiquitination-regulating domain and agents and antibodies that regulate ubiquitination in cells, e.g., by modulating the interaction between a TSG101 protein and an MDM2 protein.

Abstract: A position detecting device selects sensors arranged in the order of sensor 1, 2, 3, 4, 5, and 6 in an X-axis direction and a Y-axis direction. In a first selection pattern, the device selects a sensor in the order of sensor 1, 6, 2, 5, 3, and 4. In a second pattern, the device selects a sensor in the order of sensor 1, 6, 5, 2, 3, and 4. In a third pattern, the device selects a sensor in the order of sensor 1, 6, 2, 5, 4, and 3. In a fourth pattern, the device selects a sensor in the order of sensor 1, 6, 5, 2, 3, and 4. By selecting the sensors 1 to 6 in an order different from the order of the arrangement and communicating signals with a position pointer, the device detects the position pointed by the position pointer.

Abstract: The present invention is directed to a machine programmed to edge an ophthalmic lens blank. The machine includes an edger device for forming a bevel in a peripheral edge of the lens blank, a central processing unit operably associated with the edger device for controlling operation thereof, and a computer program stored on a medium in communication with the central processing unit. The computer program includes a first instruction set operably causing the edger device to form a bevel in a peripheral edge of a lens blank. A second instruction set operably causes the edger device to form a step in the peripheral edge intermediate an apex of the bevel and an interface between the peripheral edge and a major surface of the lens blank. A method of controlling an edger device for edging an ophthalmic lens blank and a computer program are also disclosed.

Abstract: The invention relates to a method and device with which it is possible to arrange complicated shapes with considerable differences in height in wood fiber board, and in particular but not exclusively so called MDF (Medium Density Fiberboard). The deformation of the wood fiber board which can be achieved with the invention is known in the art as extusion, wherein a considerable plastic deformation takes place accompanied by flow and stretch of the material.