Patents Represented by Attorney Berlex Inc.

Find this attorney in the Justia Lawyer Directory

  • 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 7196202
    Abstract: The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: March 27, 2007
    Assignee: Schering AG
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Monning, Herbert Schneider
  • Modified corin molecules having substitute activation sequences and uses thereof
    Patent number: 7176013
    Abstract: This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: February 13, 2007
    Assignee: Schering Aktiengesellschaft
    Inventor: Qingyu Wu
  • Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons
    Patent number: 7138379
    Abstract: The present invention is directed towards a method of potentiating the anti-growth effects of type I interferon (IFN) on cells in a target cell population comprising increasing the number of functional IFNAR2c receptors on the surface of modified cells within the target cell population and then exposing the modified cells to a therapeutically effective amount of a type I IFN or by exposure to endogenously produced IFN.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: November 21, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Ed Croze, David Vogel, Dean Russell-Harde
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7115645
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 3, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • Indolinone derivatives and their use in treating disease-states such as cancer
    Patent number: 7105563
    Abstract: Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: September 12, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Damian Arnaiz, Judi Bryant, Yuo-Ling Chou, Richard Feldman, Paul Hrvatin, Imadul Islam, Monica Kochanny, Wheeseong Lee, Mark Polokoff, Hongyi Yu, Shendong Yuan
  • Aminoalkyl-3, 4-dihydroquinoline derivatives as no-synthase inhibitors
    Patent number: 7067667
    Abstract: 3,4-dihydroquinoline derivatives, a process for their production and their use in pharmaceutical agents.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: June 27, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Stefan Jaroch, Hartmut Rehwinkel, Peter Holscher, Detlev Sülzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdougall McDonald
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6982259
    Abstract: N-Heterocyclic derivatives of the following formula: where m, n, p, A1, R1, R2, R3 and R4 are described herein, as well as other N-heterocyclic derivatives, are useful as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: January 3, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: David D. Davey, Raju Mohan, Gary B. Phillips, Guo Ping Wei, Wei Xu
  • Piperazine derivatives and their use as anti-inflammatory agents
    Patent number: 6977258
    Abstract: This invention is directed to acyl piperazine derivatives of formula (Ia): wherein R1a, R2, R3, R4, R5 and R6 are defined herein, which are useful as anti-inflammatory agents. This invention is also directed to other acyl piperazine derivatives, pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat inflammatory disorders in humans.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: December 20, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: John G. Bauman, Brad O. Buckman, Ameen F. Ghannam, Joseph E. Hesselgesser, Richard Horuk, Imadul Islam, Meina Liang, Karen B. May, Sean D. Monahan, Michael M. Morrissey, Howard P. Ng, Kenneth J. Shaw, Guo Ping Wei, Wei Xu, Zuchun Zhao, Wei Zheng
  • 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
    Patent number: 6962932
    Abstract: New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: November 8, 2005
    Assignee: Schering Aktiengesellschaft
    Inventors: Thorsten Blume, Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning, Bernd Elger, Herbert Schneider
  • Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
    Patent number: 6914059
    Abstract: Compounds of formula I, their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical agents are described.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: July 5, 2005
    Assignee: Schering AG
    Inventors: Hartmut Rehwinkel, Peter Hoelscher, Stefan Jaroch, Detlev Suelzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdonald McDonald