Patents Represented by Attorney Berlex Inc.

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  • Modified corin molecules having substitute activation sequences and uses thereof
    Patent number: 7176013
    Abstract: This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.
    Type: Grant
    Filed: June 9, 2004
    Date of Patent: February 13, 2007
    Assignee: Schering Aktiengesellschaft
    Inventor: Qingyu Wu
  • 1,2 diarylbenzimidazoles and their pharmaceutical use
    Patent number: 7115645
    Abstract: Benzimidazoles of general formula I and the use of benzimidazole derivatives for the production of pharmaceutical agents for treatment and prophylaxis of diseases that are associated with a microglia activation are described.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: October 3, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Wolfgang Halfbrodt, Joachim Kuhnke, Ursula Moenning
  • Indolinone derivatives and their use in treating disease-states such as cancer
    Patent number: 7105563
    Abstract: Indolinone derivatives, such as compounds of the formula (I): wherein A, m, n, R1, R2, R3, R5 and R6 are described herein, are disclosed herein as being useful in treating mammal having disease-states alleviated by the inhibition of PDK-1 activity.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: September 12, 2006
    Assignee: Schering Aktiengesellschaft
    Inventors: Damian Arnaiz, Judi Bryant, Yuo-Ling Chou, Richard Feldman, Paul Hrvatin, Imadul Islam, Monica Kochanny, Wheeseong Lee, Mark Polokoff, Hongyi Yu, Shendong Yuan
  • Benzoxazine and benzothiazine derivatives and the use thereof in medicaments
    Patent number: 6914059
    Abstract: Compounds of formula I, their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical agents are described.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: July 5, 2005
    Assignee: Schering AG
    Inventors: Hartmut Rehwinkel, Peter Hoelscher, Stefan Jaroch, Detlev Suelzle, Margrit Hillmann, Gerardine Anne Burton, Fiona Mcdonald McDonald