Patents Represented by Attorney Bernard Friedrichsen

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  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Patent number: 7816367
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Grant
    Filed: February 24, 2005
    Date of Patent: October 19, 2010
    Assignee: Amgen Inc.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel C. H. Lin, Jiwen Liu, Jian Luo, Julio C. Medina, Wei Qiu, Jeffrey D. Reagan, Rajiv Sharma, Stephen J. Shuttleworth, Ying Sun, Jian Zhang, Liusheng Zhu, Jinqian Liu, Zhihua Ma, Yingcai Wang, Michael J. Schmitt
  • Heterocyclic GPR40 modulators
    Patent number: 7714008
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: May 11, 2010
    Assignee: Amgen Inc.
    Inventors: Hilary Beck, Paul Dransfield, Zice Fu, Jonathan B. Houze, XianYun Jiao, Todd J. Kohn, SuJen Lai, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio C. Medina, Michael J. Schmitt, Rajiv Sharma, Wang Shen, Marc Vimolratana, Yingcai Wang, Zhongyu Wang
  • Thiadiazole compounds and methods of use
    Patent number: 7700636
    Abstract: The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: April 20, 2010
    Assignee: Amgen Inc.
    Inventors: Holger Monenschein, George Erich Wohlhieter, Qingping Zeng
  • Benzo-fused compounds for use in treating metabolic disorders
    Patent number: 7687526
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: March 30, 2010
    Assignee: Amgen Inc.
    Inventors: Sean P. Brown, Paul Dransfield, Jonathan B. Houze, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio C. Medina, Vatee Pattaropong, Michael J. Schmitt, Rajiv Sharma, Yingcai Wang
  • Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders
    Patent number: 7649110
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q—L1—P—L2—M—X—L3—A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: January 19, 2010
    Assignee: Amgen Inc.
    Inventors: Michelle Akerman, Jonathan Houze, Daniel C. H. Lin, Jinqian Liu, Jiwen Liu, Jian Luo, Zhihua Ma, Julio C. Medina, Wei Qiu, Jeffrey D. Reagan, Rajiv Sharma, Michael J. Schmitt, Stephen J. Shuttleworth, Ying Sun, Yingcai Wang, Jian Zhang, Liusheng Zhu
  • Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof
    Patent number: 7635715
    Abstract: Compounds of Formula I and Formula II are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: December 22, 2009
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Kaustav Biswas, Marian C. Bryan, Roland Burli, Guo-Qiang Cao, Michael J. Frohn, Jennifer E. Golden, Stephanie Mercede, Susana Neira, Tanya Peterkin, Alexander J. Pickrell, Anthony Reed, Christopher M. Tegley, Xiang Wang
  • Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders
    Patent number: 7582803
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: September 1, 2009
    Assignee: Amgen Inc.
    Inventors: Michelle Akerman, Sean Brown, Jonathan B. Houze, Jinqian Liu, Jiwen Liu, Zhihua Ma, Julio C. Medina, Wei Qiu, Michael J. Schmitt, Yingcai Wang, Liusheng Zhu, Rajiv Sharma
  • Substituted biphenyl GPR40 modulators
    Patent number: 7572934
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: August 11, 2009
    Assignee: Amgen Inc.
    Inventors: Sean P. Brown, Paul Dransfield, Zice Fu, Jonathan Houze, Xian Yun Jiao, Todd J. Kohn, Vatee Pattaropong, Marc Vimolratana, Michael J. Schmitt
  • Indanone derivatives that inhibit prolyl hydroxylase
    Patent number: 7569726
    Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: August 4, 2009
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Roland Burli, Jennifer E. Golden, Kristine M. Muller, Anthony B. Reed