Abstract: Compounds of the formula
where R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
Type:
Grant
Filed:
December 15, 1998
Date of Patent:
June 19, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Wilhelm Amberg, Harald Bernard, Ernst Buschmann, Andreas Haupt, Lothar Janitschke, Bernd Janssen, Ulrich Karl, Andreas Kling, Stefan Müller, Bernd de Potzolli, Kurt Ritter, Marco Thyes, Thomas Zierke
Abstract: Methods and assays are disclosed for predicting a patient's risk for an inflammatory disorder such as coronary artery disease or related vascular disorders. The methods comprise obtaining a biological sample from a patient and determining the presence or absence of a particular allele which is linked with coronary artery disease. Detection of the allele is indicative of susceptibility to develop coronary artery disease. Kits for the detection of coronary artery disease are additionally provided, as are means for identifying additional alleles associated with coronary artery disease.
Type:
Grant
Filed:
March 10, 1997
Date of Patent:
April 3, 2001
Assignee:
Interleukin Genetics, Inc.
Inventors:
Sheila E. Francis, David C. Crossman, Gordon W. Duff
Abstract: Methods and compositions for treating glaucoma and methods and compositions for prognosing or diagnosing glaucoma in a subject are disclosed.
Type:
Grant
Filed:
May 22, 1998
Date of Patent:
March 27, 2001
Assignee:
University of Iowa Research Foundation
Inventors:
Val C. Sheffield, Wallace L. M. Alward, Edwin M. Stone, Darryl Nishimura, Shiva Patil
Abstract: Novel meta substituted arylakylamine compounds are disclosed. These compounds can be administered as small molecule drugs to treat diseases or conditions associated with insufficient serotonin mediated nerve transmission (e.g. depression and obesity).