Patents Represented by Law Firm Birch, Stewart & Birch
  • Patent number: 6187793
    Abstract: 7-[3-[4-(6-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]propoxy]-chromen-4-one derivatives having the formula (I): wherein R is hydrogen, CHO, CH2OR2 or COOH; R1 is hydrogen or CH2OH; and R2 is alkyl having 1 to 4 carbon atoms with the proviso that one of substituents R and R1 should be hydrogen, as well as their pharmaceutically acceptable salts. The process for their preparation and the pharmaceutical compositions containing them are also described. The compounds are new and are useful in the treatment of psychosis, schizophrenia and allergy.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: February 13, 2001
    Assignee: Ferrer Internacional, S.A.
    Inventors: Rafael Foguet, Jordi Bolós, Aurelio Sacristán, Josep M. Castelló, José A. Ortiz
  • Patent number: 6159974
    Abstract: LDL receptor gene expression promoters containing a 1,2,4-triazine derivative of the formula (I): ##STR1## wherein R.sup.1 is optionally substituted phenyl or heterocycle; R.sup.2 is optionally substituted phenyl, naphthyl, aralkyl, 5- or 6-membered aromatic heterocycle, alkyl, or alkenyl; X is O, S or NR.sup.4 ; R.sup.3 is optionally substituted phenyl, naphthyl, aralkyl, 5- to 6-membered aromatic heterocycle, alkyl, cycloalkyl or alkenyl, provided that when X is NR.sup.4, then it may form an optionally substituted nitrogen-containing heterocycle, or a pharmaceutically acceptable salt thereof, which can increase the expression dose (the amount of mRNA) of LDL receptor gene, and thus increase the amount of LDL receptor, and reduce the serum cholesterol level, and are useful in the treatment of hyperlipidemia.
    Type: Grant
    Filed: September 24, 1999
    Date of Patent: December 12, 2000
    Assignee: Sumitomo Pharmaceuticals Company, Limited
    Inventors: Yoshihide Ueno, Koji Morishita, Masami Muraoka, Naohito Ohashi
  • Patent number: 6156853
    Abstract: Disclosed are a deposit suppressant composition for the internal surfaces of a polymerization reactor for polymerizing a vinyl monomer, including a polyhydric phenol sulfide compound having an average molecular weight of about 500 to 5000, as well as a method of polymerizing a vinyl monomer wherein prior to the polymerization, the internal surfaces of a polymerization reactor are coated with the deposit suppressant composition.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: December 5, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takeshi Sumino, Tetsuyoshi Yano, Masayuki Murashige
  • Patent number: 6156891
    Abstract: Carboxylic acids of formula (1): ##STR1## wherein R.sup.2 and R.sup.3 are independently hydrogen or C.sub.1 -C.sub.3 alkyl, and Q is optionally substituted phenyl, can be easily converted by ring closing into pyridazin-3-one derivatives of formula (7): ##STR2## The carboxylic acids of formula (1) can be produced by reacting hydrazone compounds of formula (5): ##STR3## wherein R.sup.3 and Q are as defined above, with malonic acid derivatives of formula (6):R.sup.2 CH(COOH).sub.2wherein R.sup.2 is as defined above in the presence of a base.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: December 5, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Takashi Furukawa
  • Patent number: 6143053
    Abstract: In a process for producing sponge iron by direct reduction of iron-oxide-containing material, synthesis gas is mixed with top gas forming in the direct reduction of the iron-oxide-containing material and is utilized as a CO- and H.sub.2 -containing reducing gas for direct reduction and for heating the iron-oxide-containing material to a reduction temperature. To be able to save energy in an economically efficient manner when producing steel, especially in the refining process, direct reduction is carried out as follows: (1) in addition to the reducing gas, a carbon-containing gas, such as natural gas, or a gas having higher hydrocarbons is utilized for reduction; (2) the iron-oxide-containing material for a predetermined period of time exceeding the period necessary for complete reduction is exposed to the reducing gas and to the additionally supplied carbon-containing gas, and (3) a CO/CO.sub.2 ratio ranging between 2 and 5, preferably a ratio in excess of 2.5, is adjusted in the reducing gas.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: November 7, 2000
    Assignee: Voest-Alpine Industrieanlagenbau GmbH
    Inventors: Johann Reidetschlager, Siegfried Zeller, Felix Wallner, Roy Hubert Whipp, Jr.
  • Patent number: 6143500
    Abstract: The present invention is drawn to nucleic acid fragments specific to Xanthomonas campestris pathogenic to plants belonging to the family Gramineae, as well as methods for detecting the pathogenic Xanthomonas campestris using the same. The nucleic acid fragment of the invention has a nucleotide sequence which is at least 15 consecutive nucleotides of the nucleotide sequence shown in SEQ ID NO:1 or in the complementary chain thereof, or has no less than 15 nucleotides and hybridizes with the nucleic acid having the sequence shown in SEQ ID NO:1 or with the complementary chain thereof under stringent conditions.
    Type: Grant
    Filed: September 4, 1998
    Date of Patent: November 7, 2000
    Assignee: Japan Tobacco, Inc.
    Inventor: Tomoki Nishino
  • Patent number: 6140350
    Abstract: A method for controlling ectoparasites systemically through host animal blood which comprises administering at least one neonocotinoid compound among those defined in the specification to the host animal.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: October 31, 2000
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Satoshi Sembo
  • Patent number: 6093529
    Abstract: An imaging material is provided in the form of a photothermographic or thermographic image forming layer containing an organic silver salt on one surface of a support and further comprising a polyvalent metal ion and a phthalic acid compound on the image forming layer-bearing surface of the support. The imaging material has improved shelf stability before and after image formation and the ease of handling and produces high-quality blue black tone images.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: July 25, 2000
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Hirohiko Tsuzuki, Hisashi Okamura, Itsuo Fujiwara, Yoshiharu Yabuki, Masaki Noro
  • Patent number: 5281574
    Abstract: There is disclosed a 1-phenyl-4 trifluoromethyl-uracil derivative of the general formula: ##STR1## wherein R.sup.1 is hydrogen or methyl, and R.sup.2 is C.sub.1 -C.sub.7 alkyl or C.sub.3 -C.sub.7 cycloalkyl optionally substituted with C.sub.1 -C.sub.3 alkyl. Also disclosed are a herbicidal composition containing this derivative as an active ingredient and a method for exterminating undesired weeds by application of this herbicidal composition.
    Type: Grant
    Filed: October 29, 1992
    Date of Patent: January 25, 1994
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayuki Enomoto, Susumu Takemura, Masaharu Sakaki, Shinsuke Shojima, Eiki Nagano
  • Patent number: 4575601
    Abstract: There is disclosed an electrical signal input device suitable for use in a microwave oven or other household appliance for introducing a setting into those appliances through a simple one-touch actuation. The input device is of the membrane type which includes an actuator member composed of a generally flat plate having a plurality of elongated actuator sections on a surface thereof and carrying a plurality of first electrodes disposed wholly through an opposite surface thereof and facing against the plurality of the actuator sections, a substrate disposed in conjunction with the actuator member and having a plurality of second electrodes each corresponding to one of the first electrode. The first and second electrodes are brought into electrical contact when the corresponding one of the actuator sections is depressed and becomes bent. Discrete values of electrical resistance are sensed as a function of where the first and second electrodes are in electric contact along the length of the actuator sections.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: March 11, 1986
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Toshimichi Taguchi, Hideyuki Akao
  • Patent number: 4569029
    Abstract: Disclosed is a check calculator as a preferred embodiment of the present invention, which is characterized in that;It displays the amount of the check drawn on a payee and the deposit balance after the check has been drawn on a payee, then instructs either writing or reading of the number of the check drawn on a payee in response to specific operations of the keys provided, more particularly, when drawing a check on a payee, in responding to the reading operation of the reading key, the check calculator reads out the number of the check to be drawn next on a payee and also reads the deposit balance after the check has been drawn on a payee.
    Type: Grant
    Filed: September 10, 1982
    Date of Patent: February 4, 1986
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Koichi Hatta, Kenichiro Komeda