Abstract: Compounds of the formula I:
where;
R1 is O, S;
R2 is an optionally substituted nitrogen-containing heterocycle, wherein the nitrogen is located at the 2 position relative to the (thio)urea bond;
R3 is H, C1-C3 alkyl,
R4-R7 are independently selected from H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, haloC1-C6 alkyl, C1-C6 alkanoyl, haloC1-C6 alkanoyl, C1-C6 alkoxy, haloC1-C6 alkoxy, C1-C6 alkyloxy-C1-C6 alkyl, haloC1-C6 alkyloxy-C1-C6 alkyl hydroxy-C1-C6 alkyl, amino-C1-C6 alkyl, carboxy-C1-C6 alkyl, cyano-C1-C6 alkyl, amino, carboxy, carbamoyl, cyano, halo, hydroxy, keto;
X is —(CR8R9)n—
R8 and R9 are independently H, C1-C3 alkyl, OH or R8 and R9 together are ═O
n is 1, 2 or 3
and prodrugs and pharmaceutically acceptable salts thereof, have utility as inhibitors of HIV-1 reverse transcriptase, particularly drug escape mutants.
Type:
Grant
Filed:
March 5, 2002
Date of Patent:
August 26, 2003
Assignee:
Medivir AB
Inventors:
Christer Sahlberg, Dmitry Antonov, Hans Wallberg, Rolf Noréen
Abstract: In an exhaust control valve having a valve housing and a valve body rotatably contained in the valve housing, a transmission member is fitted to an outer end of the valve shaft and protrudes from the outside of the valve housing. A bearing bushing for rotatably bearing an external circumferential surface of the valve shaft by its internal circumferential surface and rotatably bearing an end face of the valve body by its end face is mounted in the valve housing. The valve body is urged by load from a thrust spring for achieving a pressure contact seal condition between the opposed end faces of the bearing bush and the valve body.
Abstract: A method for controlling a motor-driven injection molding machine which includes a plurality of drive motors. In the method, load current flowing through at least one drive motor serving as a drive source is detected in order to estimate heat generation value of the drive motor. When the estimated heat generation value reaches a preset stopping point, the drive motor is stopped. When the estimated heat generation value reaches a preset alarming point, which is lower than the stopping point, an alarm is issued.
Abstract: Internet Call Center quality of service is enhanced by directing all callers' browser-initiated contact requests to a single Internet Interface Controller. Upon receiving a caller's contact request, ruled-based routing is applied at the Internet Interface Controller to determine the Call Center, from among the Enterprise-wide domain of Call Centers, best suited for servicing the call. A pre-routed contact request is created establishing the Call Center best suited for servicing the call as the appropriate destination Call Center and a session is established between the caller and the Call Center best suited for servicing the call.
Abstract: An electron gun assembly for a CRT includes three cathode electrodes, a control electrode, an electron-stream extractor electrode, a focusing electrode, and an anode electrode. The electron-stream extractor electrode includes first, second, and third holes, each of which allows one of the three streams of the electrons to pass through. The focusing electrode includes a flat portion having fourth, fifth, and sixth holes, each of which allows one of the three streams of the electrons to pass through. The first, second, and third holes are arranged in the in-line direction. Each of the fourth and sixth holes includes a substantially rectangular opening and a substantially semicircular opening connected to each other. One side of the substantially rectangular opening is connected to a straight line segment of the substantially semicircular opening, and the substantially rectangular opening is disposed outside while the substantially semicircular opening is disposed inside.
Abstract: Disclosed is a flame retardant polybutyleneterephthalate resin prepared be copolymerizing a phosphorus-based flame retardant represented by the following formula I and a butyleneterephthalate unit:
wherein R1 and R2 are different or the same and are methyl or butyl including a hydroxyl group.
Type:
Grant
Filed:
May 10, 2002
Date of Patent:
August 26, 2003
Assignee:
Kolon Industries Inc.
Inventors:
Young-Ik Seo, Chung-Seock Kang, Tae-Gun Choi, Jun-Myoung Song
Abstract: A hydraulic control system in which hydraulic pressure generated pressure generated by an oil pump is supplied to a pressure/damper clutch controller, a pressure reducer, and a shift controller, wherein the pressure reduced by the pressure reducer and the hydraulic pressure supplied as a result of port conversion of the sift controller are supplied to the hydraulic pressure controller, and hydraulic pressure controlled by the hydraulic pressure controller is supplied to a hydraulic pressure distributor and directly to some friction elements.
Abstract: A portable telemedicine device used in prehospital, preliminary diagnostic procedures and treatments includes a data processing unit for receiving and processing data. Measurement devices for determining patient data relative to a predetermined patient. Presentation device for displaying patient data received from the measurement devices. Entry device for manually inputting manual data into the data processing unit. Communication equipment for permitting bidirectional communication with at least one central unit for transmitting manually entered manual data and patient data to the central unit and to receive information data from the central unit representing results from diagnoses, suggested care and previously stored data on the predetermined patient. A predetermined number of the data processing unit, measurement devices, presentation device, entry device and communication equipment being integrated into a portable unit.
Abstract: In a fluorosilicone rubber composition comprising (A) an organopolysiloxane having trifluoropropyl and (B) a silica filler, there are included (C) an organic peroxide of percarbonate type as a crosslinking agent and (D) a compound having a molecular weight of up to 10,000 and bearing in a molecule at least two substituents selected from among allyl, acryloyl, methacryloyl, epoxy and alkoxy groups as a co-crosslinking agent, whereby the vulcanization molding time is substantially reduced without detracting from physical properties.
Abstract: A method for controlling a motor-driven injection molding machine in which heat generation of a drive section including a drive motor is monitored, and when the drive section enters an overload state, the drive motor is stopped. In the method, during molding, heat generation value (overload factor) of the drive motor is estimated from load current flowing through the drive motor. When the estimated heat generation value (overload factor) reaches a preset stopping point or when a thermostat attached to the drive section outputs an overload detection signal indicating an overload state, the drive motor is stopped.
Abstract: A method and mechanism for adjusting/controlling the pitch of at least one blade of a wind turbine relative to a wind direction parallel to a longitudinal main shaft of the wind turbine use a mechanism with a motor for rotating drive wheels in the angle gear around a longitudinal blade shaft via drive wheels of an angle gear. The method and mechanism can stop the complete turning of a main shaft of a wind turbine having a motor to rotate a drive pinion in an angle gear via a drive wheel, the angle gear being meant to pitch at least one blade around a longitudinal axis.
Abstract: A feature coding unit extracts and encodes a feature of a video signal so as to generate a feature stream. A feature identifying unit checks a decoded feature obtained as a result of decoding the feature stream against a search key from a user for a match so that a video content requested by the user is retrieved.
Type:
Grant
Filed:
November 17, 2000
Date of Patent:
August 26, 2003
Assignee:
Mitsubishi Denki Kabushiki Kaisha
Inventors:
Shunichi Sekiguchi, Yoshihisa Yamada, James Chow, Kohtaro Asai
Abstract: The present invention relates a method for transforming a rice plant to provide it with a C4 photosynthetic pathway by way of the introduction of some genes participating in a C4 photosynthetic pathway. To this end, the method of the invention comprises introducing a phosphoenolpyruvate carboxylase (PEPC) and a gene coding for a phosphoenolpyruvate carboxykinase (PCK) which has been connected with a DNA fragment coding for a transit peptide into a rice plant.
Type:
Grant
Filed:
December 10, 1998
Date of Patent:
August 26, 2003
Assignee:
Japan Tobacco, Inc.
Inventors:
Masao Arai, Shoichi Suzuki, Nobuhiko Murai, Shigehiro Yamada, Shozo Ohta, James N. Burnell
Abstract: A radar signal processing apparatus has a range gate for extracting range gate data sequences from a memory, a first frequency extraction section which extracts a beat frequency corresponding to a target by performing frequency analysis by FFT at a low computation load and with low frequency measurement accuracy on all range gate data sequences extracted by the range gate, a second frequency extraction section which extracts a beat frequency corresponding to the target by performing frequency analysis by FFT at a high computation load and with high frequency measurement accuracy only on the range gate data sequence from which a beat frequency has been extracted by the first frequency extraction section, and a distance and speed derivation section which obtains the relative distance and the relative speed of the target on the basis of the beat frequency extracted by the second frequency extraction section.
Type:
Grant
Filed:
May 3, 2002
Date of Patent:
August 26, 2003
Assignee:
Mitsubish Denki Kabushiki Kaisha
Inventors:
Masashi Mitsumoto, Takahiko Fujisaka, Koichi Kai
Abstract: The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome,
Pharmaceutical compositions comprising said novel methane derivatives, process for the preparation of the novel methane derivatives and methods for the treatment of esterogen related diseases or syndrome.
Type:
Grant
Filed:
March 31, 2000
Date of Patent:
August 26, 2003
Assignee:
Council of Scientific and Industrial Research
Abstract: Disclosed is a polyamide ester which comprises a plurality of specific amide ester recurring units including, in a specific ratio, recurring units containing a tetravalent benzene group and recurring units containing a tetravalent diphenyl ether group, and which is adapted to be converted to a polyimide in a coating form by heat-curing, wherein the polyimide coating exhibits a residual stress of 33 MPa or less as measured with respect to a 10 &mgr;m-thick polyimide coating formed on a silicon substrate. Also disclosed is a polyamide ester composition comprising a plurality of different polyamide esters, wherein the plurality of different polyamide esters collectively contain, in a specific ratio, the recurring units containing a tetravalent benzene group and the recurring units containing a tetravalent diphenyl ether group.
Abstract: The present invention relates to a method for detecting blood characteristics including hemoglobin in a fluid medium using both transmission and reflection of a light beam which forms a quotient.
Type:
Grant
Filed:
September 7, 2000
Date of Patent:
August 26, 2003
Assignee:
OptoQ AB
Inventors:
Lars-Göran Lindberg, Gunnar Enlund, Magnus Vegfors
Abstract: A silver halide photographic material having high sensitivity, low fog and good shelf life (i.e., storage stability), which comprises at least one kind of merocyanine dye represented by formula (I):
wherein Z1 represents an atomic group necessary for forming a naphthoxazole ring, R1 and R2 each represents an unsubstituted or substituted alkyl group, an aryl group or a heterocyclic group, L1, L2, L3 and L4 each represents a methine group, M1 represents a charge neutralizing counter ion, and m1 is a number of 0 or more necessary for neutralizing a charge in a molecule.
Abstract: The invention provides an ethylene-&agr;-olefin-unconjugated polyene random copolymer rubber having hydrolyzable silyl groups in the molecule, which is crosslinkable with air-borne moisture at room temperature and is not only useful for resin modification, but also applicable as elastic sealants and adhesives, and a method for preparing the same.
Type:
Grant
Filed:
March 23, 2001
Date of Patent:
August 19, 2003
Assignees:
Shin-Etsu Chemical Co., Ltd., Mitsi Chemicals, Inc.
Abstract: A universal motor has a brush holder assembly which is fixed to a support bracket using a single fastener. The brush holder assembly uses a terminal cap to secure the brush and brush spring within the brush holder. The terminal cap is fixed to the brush holder and compresses the brush spring by movement of the terminal cap in a single direction.