Patents Represented by Law Firm Bonner & Witcoff, Ltd.
  • Delivery of compacted nucleic acid to cells
    Patent number: 6077835
    Abstract: Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: June 20, 2000
    Assignees: Case Western Reserve University, Ohio University
    Inventors: Richard W. Hanson, Jose C. Perales, Thomas W. Ferkol, Jr.