Abstract: The peristaltic pump of the invention incorporates at least one pumping roller and one occluding roller. The occluding roller is located diametrically across the pumping roller and is designed to provide occlusion only and not progressive squeezing of the pump tubing while rotating in the same direction as the pumping roller. Such occlusion prevents back-flow through the tubing. More than two rollers spaced evenly along the periphery of the rotor allow for various useful combinations of pumping and occluding rollers. Two occluding and one pumping roller combination creates a pulsatile flow close to that of a human heart—with systole being about twice shorter than diastole.

Abstract: The present invention is used in conjunction with a multi-channel system of a production string for deployment in gas, condensate or oil wells. An end-piece is placed at the entrance to such multi-channel system. It includes a semi-enclosed space helping to increase the proportion of gas phase entering the system at its bottom entrance. Increased proportion of gas allows lifting liquids and/or solids from the wellbore with greater efficiency. Examples of using the invention include wellbore water removal for gas wells with liquid loading problems, for solution gas drive or gas cap driven oils wells during their initial “natural flowing phase”, or during gas re-injection or gas-lift recovery operations for oil wells. It can also be used for gas-lifting water in water wells.

Abstract: Acoustics-based methods and devices to characterize a gas kick during drilling an oil, gas, or gas condensate well are described. A pressure wave may be generated by abruptly changing the drilling mud pressure in the well, for example at the well head. The pressure wave is allowed to travel down the well, reflect from the well bottom and reach the well head again. Pressure is monitored during this process and a pressure peak is identified. The gas kick is characterized using the width of the pressure peak and time elapsed from the onset of pressure change and appearance of the peak. Negative pressure wave is preferred and may be generated by opening of a fast-acting valve located in the outlet pathway of the drilling mud fluid.

Abstract: Methods for assessment of pelvic floor conditions based on tactile imaging are described. The vaginal wall is deformed using a transvaginal probe equipped with tactile pressure sensors and a motion tracking sensor. The vaginal wall coordinates and pressure patterns are obtained during the examination and used to build 3-D tactile image of the vagina and to calculate elasticity modulus profiles and spacing profiles along selected lines inside 3-D tactile image. The profile values at specified locations are then compared with thresholds or profiles for normal conditions of vagina and its support structures. Methods of the invention are disclosed to be used in assessing a risk of pelvic organ prolapse development, estimating an extent of pelvic floor organ traumatic damage after childbirth and estimating an improvement after an interventional procedure.

Abstract: A novel method for soft tissue characterization includes obtaining a sequence of surface stress patterns as a function of an increasing compression force when a probe is pressed against the tissue over the location of the lesion of interest. A number of elasticity features are then calculated to characterize the tissue and the lesion located therein including strain hardening, loading curve average slope, lesion peak signal under a predetermined load, tissue heterogeneity, lesion shape and lesion mobility. At least three elasticity features are provided as an input to a statistical Bayesian classifier trained on a clinical database to calculate the probability of the lesion being benign or malignant. Additional patient-related parameters may be further provided as inputs to the classifier to increase the accuracy of differentiation between benign and malignant lesions.

Abstract: Single- or dual-bladder devices for remote ischemic preconditioning and blood pressure monitoring are disclosed along with various oscillometry-based and other methods for detecting systolic and diastolic blood pressure while the ischemic preconditioning treatment is in progress. The devices and methods of the invention provide for delivery of ischemic preconditioning at the lowest effective cuff pressure while closely monitoring patient's hemodynamics. Advantageously, the device of the invention allows both ischemic preconditioning and blood pressure monitoring to be done on the same limb. Disposable battery-powered version of the device of the present invention is especially useful for emergency use with patients suffering from acute myocardial infarction, acute stroke, or acute trauma. Additional device configurations are described for use in a percutaneous intervention and vascular sealing settings.

Abstract: A tactile sensor array includes a first electrode layer and a second electrode layer with a two-phase compressible dielectric material therebetween. A ferroelectret film is used as a dielectric layer. In some embodiments, to improve sensor sensitivity and at the same time provide for high stability and reproducibility of sensor readings, the ferroelectret film is vented to atmosphere via a venting network of channels traversing at least one electrode layer and a curved rigid substrate. In some embodiments, an elastic supporting structure is provided that comprises individual elastic fastening elements connecting all layers of the sensor together. These individual elastic fastening elements are located throughout the layers of the sensor and prevent cross-talk between the individual sensors that may be caused by local shifts of parts of the sensor during use.

Abstract: Methods for characterizing elasticity of vaginal tissue are provided. A transvaginal probe is used to deform vaginal tissue during examination. The probe is equipped with pressure sensors and a motion tracking sensor. Stress and strain data is recorded during examination. Elasticity of vaginal tissue is then characterized by calculating a stress gradient defined as a ratio of stress over strain for each point of measurement. Vaginal tactile image may also be compiled to include a family of surfaces representing locations of measurement points at predefined constant levels of stress. Pelvic organ abnormality condition may be detected if the stress gradient is below either a predetermined threshold or a normal stress gradient obtained from clinical data.

Abstract: A handgrip for colonoscope shaft is equipped with force, torque, and acceleration sensors allowing for a comprehensive characterization of colonoscope shaft motion, including recognition of obstacles and recording of forces and torques applied at various times during a colonoscopy procedure. An electronic unit is adapted to receive sensors data wirelessly and calculate a variety of motion parameters guiding a medical practitioner during the procedure and aimed at making colonoscopy safer and less painful.

Abstract: A hand-held probe is configured for a prostate cancer screening test and includes a pressure sensor array, a test progression indicator, a display, and an electronic circuit for processing pressure data. The test progression indicator is configured to guide the operator during the test as to the proper position of the probe about the prostate and the progress of collecting and accumulating test data. Data quality thresholds are used to accept or reject readings from the pressure sensor array. The results are presented as either a high or low probability of prostate cancer. The probe is adapted for easy use in an office of a general practitioner.

Abstract: Ultrasound-assisted particle agglutination assay methods and apparatuses are described based on first providing a standing wave ultrasound field at a resonance frequency of a test liquid in a resonator cell containing microparticles covered with a binding agent with high affinity to an analyte sought to be detected by the assay test. Formation of the specifically-bound and nonspecifically-bound aggregates of these microparticles is then followed by effective stirring of the liquid with swept-frequency sonication causing disintegration of nonspecifically-bound aggregates and leaving specifically-bound aggregates in place for further detection and measurement. The methods and devices of the invention allow significant improvement in the sensitivity and specificity of agglutination tests and are advantageously applicable to detecting various proteins, DNA, RNA and other biologically active substances. Specific examples are provided.

Abstract: An ultrasound beacon is incorporated into a needle of a drug delivery system utilizing high intensity ultrasound energy during certain cancer treatments. The beacon is configured to generate a electrical feedback signal in response to an initial ultrasound signal sent by an ultrasound transmitter. The electrical feedback signal is then sent along two electrical conductors of the needle and further over a cable back to the electronic unit. The feedback signal is then used to generate high intensity focused ultrasound using time-reversal acoustics principles. Therapeutic application of the system of the invention includes applying high intensity focused ultrasound at the site of drug delivery to enhance local tissue uptake of injected medication.

Abstract: Ultrasound-assisted contactless stirring of liquids in a resonator cell by microparticles is achieved by repeated creating and destruction of nodal patterns associated with standing waves of various resonance frequencies causing continuous movements of microparticles inside the cell. Swept-frequency sonication technique includes using constant or variable rate of frequency change as well as a stepwise change of frequency of the transducer within a predefined range. Other useful provisions include initial detection of the set of resonance frequencies and periodic refreshing of that set. Control systems are described including means to automatically detect the resonance frequencies and maintain the operation of the transducer thereon. Advantageous designs of the apparatus are described for use in microstirring, mixing of liquids using magnetic microbeads, microbubbles, microtiter plates, microarray plates, etc.

Abstract: Methods for assessing viscoelastic properties of soft tissues are based on detecting an inflection point on a pressure-time plot when air is aspirated from a cavity placed over the tissue sample. A small diameter tube through which air aspiration is conducted is ultimately closed off by tissue being drawn into the cavity causing an abrupt change in pressure slope. First or second derivatives of the pressure-time plot can be used to detect the inflection point. Repeating the test with a different aspiration rates or after a predetermined relaxation time allows determining tissue viscosity and tissue creep in addition to tissue elasticity expressed as Young's modulus.

Abstract: A spatial profile of structural and elastic parameters along a lumen of a hollow organ is determined based on obtaining the functional dataset of pressure P, balloon volume V, and balloon linear coordinate X while continuously moving the balloon along the lumen. A comprehensive characterization of elastic properties of the tissue and geometrical parameters of the lumen are then determined using a previously obtained calibration curve of balloon pressure vs. balloon volume when the balloon is expanded freely. As opposed to prior art devices for measuring tissues elasticity at one or several distinct locations by having deploying a balloon locally, the present invention describes a device in which the balloon is continuously moved through the lumen of the hollow organ whereby allowing elasticity determination over a significant portion or the entire length of the organ.

Abstract: A method for cracking a heavy hydrocarbon is described including exposing a heterogeneous medium of the heavy hydrocarbon with a hydrogen-containing gas in a chamber to both an electronic beam and an electric discharge field at the same time so as to create a thermal non-equilibrium as well as a spatially non-uniform state for this medium. Such dual exposure allows the cracking method to proceed without high temperature and high pressure typically required therefore and thus reduces the energy consumption and impurities generated along with desirable output product. Refining of hydrocarbons is achieved by removing sulfur therefrom during cracking in the form of hydrogen sulphide. A reverse use of this method is also described, namely a unification method for light fractions to be transformed into a heavy hydrocarbon.

Abstract: A comprehensive system for objective assessment of colonoscope manipulation includes a handgrip for collecting and transmitting colonoscope handling data including force and motion data; a patient pain monitor for collecting and transmitting data on the level of patient's pain and discomfort; and digital processing means for extracting useful features such as colonoscope tip advancement speed from colonoscope-provided video images. All data is wirelessly transmitted to an electronic unit for processing and displaying on a monitor. A colonoscopy procedure is properly conducted when certain shaft advancement causes appropriate tip advancement, all without an increased level of patient's pain. The system of the invention is aimed at providing objective assessment data allowing for safer and less painful colonoscopies.

Abstract: The present invention relates to a method for real time mechanical imaging of a prostate with a transrectal probe. In the method, generating a composite two- and three-dimensional prostate mechanical image from a plurality of partial mechanical images extracted from pressure response data and a probe orientation data starts with examining the prostate by pressing a probe head pressure sensor array against it at various overlapping locations. Merging of partial mechanical images together is accomplished by analyzing an overlap between each subsequent and previous partial mechanical image. Finding the prostate is assisted with a supplemental pressure response data indicating the location of a sphincter known to be about 4-5 cm away from the prostate. Data processing is improved by including probe orientation data to further increase the accuracy and sensitivity of the method.