Abstract: The present invention provides bioconjugates comprising a sulfated polysaccharide such as alginate sulfate and hyaluronan sulfate and at least one bioactive polypeptide capable of binding a sulfate group of said sulfated polysaccharide. The bioactive polypeptide can be a heparin-binding polypeptide and/or a positively-charged polypeptide. Also, provided are delivery systems and methods for sustained release of said bioactive polypeptide(s) using said bioconjugates.
Type:
Grant
Filed:
October 11, 2005
Date of Patent:
April 14, 2009
Assignee:
Ben-Gurion University of the Negev Research and Development Authority