Abstract: Soil amendment/foliar nutrient compositions and methods for their manufacture and use are provided. The compositions are aqueous compositions that include a carbon skeleton energy component (CSE); a macronutrient; a vitamin cofactor; a complexing agent; and at least one of exotic micronutrient component and an ionophore component.
Abstract: 2,4-Pyrimidinediamine compounds represented by formula (I), methods for preparing the same and methods for treating an inflammatory disorder and for inhibiting the production of IL-23 and/or stimulating the production of IL-10 using the same:
Type:
Grant
Filed:
January 13, 2010
Date of Patent:
December 18, 2012
Assignee:
Rigel Pharmaceuticals Inc.
Inventors:
Hui Li, Esteban Masuda, Stephanie Yung, Taisei Kinoshita, Rongxian Ding, Rajinder Singh, Tarikere Gururaja, Donald G. Payan, Kin Tso
Abstract: The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.
Type:
Grant
Filed:
April 16, 1999
Date of Patent:
December 18, 2012
Assignee:
Rigel, Inc.
Inventors:
Joseph Fisher, James Lorens, Donald Payan, Alexander Rossi
Abstract: Methods, systems and computer readable media for controlling an instrument in communication with a host computer are provided. Operations of an instrument that must be completed on schedule are controlled via an embedded controller embedded in the instrument. A complete status packet is sent to a host computer from the embedded controller. Periodically, the embedded controller repeats the sending of a complete status packet to the host computer, wherein status values in the complete status packet are updated with each iteration of sending a complete status packet.
Abstract: The potential for substance abuse involving residual amounts of abusable substances remaining in used skin-worn patches is reduced by the provision of a system and method for combining the abusable substance with a separate anti-abuse substance agent as part of a removal or disposal procedure.
Abstract: Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion comprises the TM1, TM2, TM3, TM4 and TM5 regions of the GPCR; b) a stable, folded protein insertion; and c) a second portion of the GPCR, where the second portion comprises the TM6 and TM7 regions of the GPCR.
Type:
Grant
Filed:
February 16, 2011
Date of Patent:
December 11, 2012
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The invention relates to methods of using fragmented RNA, such as RNA obtained from archived fixed paraffin-embedded tissue material (FPET RNA) or other clinically biopsied tissue specimens for universal gene expression profiling.
Abstract: LED lighting systems and methods of manufacture, which include one or more of the following: (1) a solid state active heat sink for cooling one or more LED chips; (2) a front end power supply providing high voltage to the active heat sink component; (3) a front end power supply that provides a relatively low voltage load to a plurality of LED chips; (4) a front end hybrid power supply with both a high and low voltage output, wherein the high voltage is at least 2 kV higher than the low voltage output; (5) an over-mold encapsulating the front end components, wherein the over-mold is provided by a reaction injection molding process; (6) a digital micro-minor device (DMD) for providing pixilated light, color mixing, and intensity control; and (7) an optic having quantum dots (QDs), wherein the light output of the DMD activates for the QDs.
Type:
Grant
Filed:
January 24, 2011
Date of Patent:
December 4, 2012
Assignee:
Biological Illumination, LLC
Inventors:
Fredric S. Maxik, David E. Bartine, Robert R. Soler, Valerie Ann Bastien, James Lynn Schellack, Eliza Katar Grove
Abstract: A light-emitting diode (LED) lamp for producing a biologically-corrected light. In one embodiment, the LED lamp includes a color filter, which modifies the light produced by the lamp's LED chips, to increase spectral opponency and minimize melatonin suppression. In doing so, the lamp minimizes the biological effects that the lamp may have on a user. The LED lamp is appropriately designed to produce such biologically-correct light, while still maintaining a commercially acceptable color temperature and commercially acceptable color rending properties. Methods of manufacturing such a lamp are provided, as well as equivalent lamps and equivalent methods of manufacture.
Type:
Grant
Filed:
June 30, 2011
Date of Patent:
December 4, 2012
Assignee:
Biological Illumination, LLC
Inventors:
Fredric S. Maxik, Robert R. Soler, David E. Bartine
Abstract: A method and apparatus for non-invasive measurement of living body information comprises a light source configured to generate light containing a specific wavelength component, an irradiation unit configured to irradiate a subject with the light, and at least one acoustic signal detection unit including piezoelectric devices formed of a piezoelectric single crystal containing lead titanate and configured to detect an acoustic signal which is generated due to the energy of the irradiation light absorbed by a specific substance present in or on a subject.
Type:
Grant
Filed:
October 28, 2003
Date of Patent:
December 4, 2012
Assignee:
Toshiba Medical Systems Corporation
Inventors:
Shoichi Kanayama, Kazuhiro Itsumi, Omar S. Khalil, Stanislaw Kantor
Abstract: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of virus like particles with encapsidated cargo.
Type:
Grant
Filed:
November 18, 2009
Date of Patent:
December 4, 2012
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Bradley C. Bundy, James R. Swartz, Wei Chan
Abstract: Piezoelectric actuators are provided. In some instances, the piezoelectric actuators are high-precision piezoelectric actuators. The piezoelectric beams may have a bi-chevron configuration. Also provided are methods of making the piezoelectric actuators, e.g., using Micro-Electro-Mechanical System (MEMS) fabrication techniques, and methods of using the piezoelectric actuators, e.g., as valves in fluid dispensing systems.
Type:
Grant
Filed:
November 10, 2009
Date of Patent:
December 4, 2012
Assignee:
The Regents of the University of California
Inventors:
Ya-Mei Chen, Michael Stephen Sheppy, Matthew A. Hopcroft, Albert P. Pisano, Rajesh Vinodrai Mehta, Michael Alan Marcus, Gilbert Allan Hawkins
Abstract: Telomere-encoding nucleic acid nanocircles, methods for their preparation, and methods for their use are disclosed. The nanocircles can be constructed containing multiple repeats of the complement of telomere repeat sequences. The telomere-encoding nanocircles are useful for extending telomeres both in vitro and in vivo, for treating macular degeneration, the effects of skin aging, liver degeneration, and cancer. The nanocircles are further useful for treating cell cultures to produce long-lived non-cancerous cell populations. This use has wide applicability in scientific research, tissue engineering, and transplantation.
Type:
Grant
Filed:
January 26, 2009
Date of Patent:
December 4, 2012
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Abstract: The present invention generally features novel cosmetic skin and hair care compositions for enhancing the appearance of eyelashes and eyebrows. Specifically, the topical skin and hair care compositions of the invention contain a concentration of at least one of pentapeptide-17 tetrapeptide-12 that provide for thicker, longer and more voluminous appearing eyelashes and eyebrows. The cosmetic formulations of the invention may further include cosmetically acceptable vehicle(s) and/or other skin and hair conditioning agents.
Abstract: Magnetic nanoparticles and methods for their use in detecting biological molecules are disclosed. The magnetic nanoparticles can be attached to nucleic acid molecules, which are then captured by a complementary sequence attached to a detector, such as a spin valve detector or a magnetic tunnel junction detector. The detection of the bound magnetic nanoparticle can be achieved with high specificity and sensitivity.
Type:
Grant
Filed:
May 17, 2007
Date of Patent:
November 27, 2012
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Shan X. Wang, Robert L. White, Chris D. Webb, Guanxiong Li
Abstract: The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as “tiers” of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive hybridizations of labeled word complements.
Abstract: The invention includes an assembly for anastomosis having a clamp being arranged to support a fastener. The clamp can be actuated to join a vessel with the fastener to establish a fluid communication. In some embodiments, the invention includes an assembly having a clamp and a fastener with first and second joinable parts, and the assembly can be adapted to facilitate the alignment of the first and second joinable parts.
Type:
Grant
Filed:
April 6, 2006
Date of Patent:
November 20, 2012
Assignee:
Synovis Life Technologies, Inc.
Inventors:
William F. Kuester, III, Tracy Konobeck
Abstract: The present invention relates, in part, to methods and compositions for immunizing against infection by Chlamydia trachomatis. The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from C. trachomatis major outer membrane protein (MOMP) to a subject to be immunized. In some embodiments, the compositions comprise a chimeric immunogens, expression vectors comprising the polynucleotides, and kits comprising the compositions are also provided.
Type:
Grant
Filed:
May 11, 2011
Date of Patent:
November 13, 2012
Assignee:
Children's Hospital and Research Center at Oakland
Abstract: The invention features methods and compositions for diagnosis, including prognosis, of conditions associated with decreased arginine bioavailability (which can result from dysregulated arginine metabolism, e.g., due to increased arginase activity) by assessing in a sample from a subject the ratio of arginine to one or more, usually two or more, modulators of arginine bioavailability. In one embodiment, the ratio of arginine to (ornithine+citrulline) is assessed to aid in diagnosis.
Type:
Grant
Filed:
December 1, 2009
Date of Patent:
November 13, 2012
Assignees:
Children's Hospital & Research Center at Oakland, The Cleveland Clinic Foundation