Abstract: An amplified, isolated output control circuit is provided for controlling the output switching network of a self-powered defibrillator that delivers a high voltage electrical countershock through a plurality of electrodes. The defibrillator comprises a low voltage battery system, a high voltage capacitor system, a high voltage transformer connected between the battery system and the capacitor system, and an output switching network, such as an H-bridge switching network, connected between the capacitor system and the plurality of electrodes. The defibrillator is controlled by control circuitry that manages the charging and discharging of the electrical countershock and is connected to the output control circuitry. Preferably, the output control circuitry includes an isolated power supply, at least one optoisolator device and at least one amplifier circuit that is powered by the isolated power supply and is connected between the optoisolator device and a switch of the output switching network.