Abstract: Many human conditions, often skin conditions, are treated topically or orally with a retinoid such as retinoic acid or acetretin, which treatment often has the side effect of dry, irritated, and/or peeling skin. The use of soaps, detergents, chemical irritants, and such can also cause these same side effects. These side effects can be reduced or eliminated by the topical administration of an inhibitor, especially a natural inhibitor, of the epidermal growth factor receptor (EGFR), administered concomitantly with the retinoid, separately from the retinoid (such as on an as needed basis), or both. Administration of the two together is facilitated by a composition suitable for topical application and comprising both the retinoid and a natural EGFR inhibitor. Preferred natural inhibitors are genistein and other isoflavones extracted from natural occurring substances, or simple derivatives of such substances.
Type:
Grant
Filed:
February 27, 2002
Date of Patent:
October 28, 2003
Assignee:
Regents of the University of Michigan
Inventors:
Sewon Kang, Gary J. Fisher, John J. Voorhees
Abstract: In a connector having at least one contact (3a,3b) held by an insulator (2a), a high-frequency current suppressor (4a,4b) is provided on the contact or the insulator. The high-frequency current suppressor serves to attenuate a high-frequency current flowing through the contact and having a frequency within a frequency band between several tens MHz and several GHz.
Abstract: A high temperature, composite structure includes a blank of wire mesh material fabricated from drawn wire from a stainless steel rod. The drawn wire is annealed and mixed to create raw material. The mixed raw material is knitted to create the blank of wire mesh material, the blank of wire mesh material having voids formed therein. A dispersion comprising vermiculite as a binder is impregnated within the blank of wire mesh material. The dispersion substantially fills the voids of the blank of wire mesh material. A method of manufacturing the structure is further disclosed. Specifically, the method includes the steps of providing a blank of wire mesh material having voids formed therein, impregnating the blank of wire mesh material with a dispersion consisting of vermiculite, the dispersion substantially filling the voids, eliminating a water fraction of the dispersion, and pressing the impregnated blank of wire mesh material to a desired shape and density.