Abstract: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a variety of different polyketides with application as pharmaceutical and veterinary products.
Type:
Grant
Filed:
October 1, 1999
Date of Patent:
January 7, 2003
Assignee:
Kosan Biosciences, Inc.
Inventors:
Christopher Reeves, Daniel Chu, Chaitan Khosla, Daniel Santi, Kai Wu