Patents Represented by Attorney Brian J. Walsh

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  • Adipocyte-specific protein homologs
    Patent number: 6566499
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: May 20, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Murine interferon-&agr;
    Patent number: 6548056
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-&agr;, which has applications in diagnosis and therapy.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: April 15, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Andrew L. Feldhaus, Zeren Gao
  • Inhibitors for use in hemostasis and immune function
    Patent number: 6544946
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: April 8, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Gerald W. Lasser, Paul D. Bishop
  • Adipocyte complement related protein homolog zacrp3
    Patent number: 6521233
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp3, a novel member of the family of proteins bearing a collage-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp3 polypeptides.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: February 18, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Paul D. Bishop
  • Testis specific glycoprotein zpep10
    Patent number: 6498235
    Abstract: The present invention relates to zpep10 polypeptides and polynucleotides encoding the same. Zpep10 polypeptide is a testis-specific membrane glycoprotein. Zpep10 polypeptides would be useful for modulating spermatogenesis and egg-sperm interaction and would be useful to study or modulate these functions in in vitro or in vivo systems. The present invention also includes antibodies to the zpep10 polypeptides.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: December 24, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Christopher S. Piddington, Jeff L. Ellsworth
  • Adipocyte-specific protein homologs
    Patent number: 6482612
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig39, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig39 polypeptides.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: November 19, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Jacqueline M. Humes
  • Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 promoter and terminator
    Patent number: 6440720
    Abstract: Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 gene (GAP2 gene) are disclosed. The sequences are useful within DNA constructs for the production of proteins of interest in cultured P. methanolica cells. Within the expression vectors, a GAP2 promoter and/or a GAP2 terminator is operably linked to a DNA segment encoding the protein of interest.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: August 27, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: Christopher K. Raymond
  • Dialkyl ureas as calcitonin mimetics
    Patent number: 6391917
    Abstract: Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the determination of calcitonin receptor activity.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: May 21, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Charles R. Petrie, Patricia A. McKernan, Emma E. Moore, John M. Ostresh, Jean-Philippe Meyer, Richard A. Houghten, Clemencia Pinilla