Patents Represented by Attorney, Agent or Law Firm Brian K. Stierwalt
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Patent number: 6653530Abstract: Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid and tocopherol levels in oilseed plants, and in providing desirable high oleic acid seed oils.Type: GrantFiled: February 13, 1998Date of Patent: November 25, 2003Assignee: Calgene LLCInventors: Christine K. Shewmaker, B. Ganesh Bhat, Mylavaraapu Venkatramesh, Shaukat H. Rangwala, Ganesh M. Kishore, Sekhar S. Boddupalli
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Patent number: 6541259Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.Type: GrantFiled: April 14, 2000Date of Patent: April 1, 2003Assignee: Calgene LLCInventors: Michael W. Lassner, Beth Savidge, Timothy Mitsky, James Weiss, Martha Ann Post-Beittenmiller
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Patent number: 6506565Abstract: The present invention relates to nucleic acid sequences for regulating gene expression in plants. In particular, the invention relates to 5′ regulatory sequences which are useful for regulating expression of heterologous DNAs in plants and methods for identifying multiple 5′ regulatory sequences which confer a particular expression profile when operably linked to DNA sequences. The invention also relates to expression vectors containing the 5′ regulatory sequences and to transgenic plants containing the expression vectors.Type: GrantFiled: August 30, 2000Date of Patent: January 14, 2003Assignee: Monsanto Technology LLCInventors: Timothy W. Conner, Iris Tzafrir
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Patent number: 6495739Abstract: By this invention, novel nucleic acid sequences encoding for phosphatidic acid phosphatase (PAP) proteins are provided, wherein PAP protein is active in the formation of diacylglycerol from phosphatidic acid. Also considered are amino acid and nucleic acid sequences obtainable from PAP nucleic acid sequences and the use of such sequences to provide transgenic host cells capable of producing altered lipid compositions and total lipid levels.Type: GrantFiled: July 23, 1999Date of Patent: December 17, 2002Assignee: Calgene LLCInventors: Michael W. Lassner, Diane M. Ruezinsky
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Patent number: 6489461Abstract: The invention provides novel polynucleotide and polypeptide sequences involved in fatty acid beta-oxidation and to methods of producing such polypeptides using recombinannt techniques. In addition, methods are provided for using such sequences to alter lipid levels in plants by altering fatty acid beat-oxidation in host plant cells.Type: GrantFiled: June 8, 2000Date of Patent: December 3, 2002Assignee: Calgene LLCInventors: Katayoon Dehesh, Byron Froman
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Patent number: 6444876Abstract: By this invention, novel nucleic acid sequences encoding for acyl-CoA: cholesterol acyltransferase (ACAT) related proteins are provided, wherein ACAT-like protein is active in the formation of a sterol ester and/or triacylylgycerol from a fatty acyl-CoA and sterol and/or diacylglycerol substrates. Also considered are amino acid and nucleic acid sequences obtainable from ACAT-like nucleic acid sequences and the use of such sequences to provide transgenic host cells capable of producing sterol esters and/or triacylglycerols.Type: GrantFiled: June 4, 1999Date of Patent: September 3, 2002Assignee: Calgene LLCInventors: Michael W. Lassner, Diane M. Ruezinsky
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Patent number: 6429356Abstract: Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid levels in oilseed plants and in providing desirable high oleic acid seed oils.Type: GrantFiled: August 8, 1997Date of Patent: August 6, 2002Assignee: Calgene LLCInventor: Christine K. Shewmaker
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Patent number: 6380466Abstract: Rapeseed in plants producing rapeseed which have a yellow-seed coat are provided. The yellow-seed coat is controlled by a single locus mutation. Plants from the rapeseed are useful for transferring the trait into elite lines of canola.Type: GrantFiled: May 4, 1998Date of Patent: April 30, 2002Assignee: Calgene LLCInventor: Daniel Facciotti
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Patent number: 6380462Abstract: This invention relates to a method for increasing stearate as a component of total triglycerides found in soybean seed. The method generally comprises growing a soybean plant having integrated into its genome a DNA construct comprising, in the 5′ to 3′ direction of transcription, a promoter functional in a soybean plant seed cell, a DNA sequence encoding an acyl-ACP thioesterase protein having substantial activity on C18:0 acyl-ACP substrates, and a transcription termination region functional in a plant cell. The present invention also provides a soybean seed with about 33 weight percent or greater stearate as a component of total fatty acids found in seed triglycerides.Type: GrantFiled: July 22, 1999Date of Patent: April 30, 2002Assignee: Calgene LLCInventor: Jean Kridl
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Patent number: 6365802Abstract: This invention relates to a method for increasing stearate as a component of total triglycerides found in soybean seed. The method generally comprises growing a soybean plant having integrated into its genome a DNA construct comprising, in the 5′ to 3′ direction of transcription, a promoter functional in a soybean plant seed cell, a DNA sequence encoding an acyl-ACP thioesterase protein having substantial activity on C18:0 acyl-ACP substrates, and a transcription termination region functional in a plant cell. The present invention also provides a soybean seed with about 33 weight percent or greater stearate as a component of total fatty acids found in seed triglycerides.Type: GrantFiled: August 14, 1998Date of Patent: April 2, 2002Assignee: Calgene LLCInventor: Jean C. Kridl
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Patent number: 6171640Abstract: The utility of soybeans having a composition of greater than 40% of the protein as beta-conglycinin and less than 10% of the protein as glycinin for making highly functional high beta-conglycinin compositions was discovered. The discovered ingredients are useful for mimicking the texturizing properties of casein while also maintaining or improving physiological benefits of soy protein ingredients (e.g., cholesterol and triglyceride lowering properties). The high stability of the high beta-conglycinin compositions against protein-protein aggregation reactions is valuable for creating good tasting beverages and beverage mixes. Cheese with good spreadability, gloss and smoothness was made using an enzyme-modified version of the new ingredient composition. Cheese with good firmness and meltability was also created using a different enzyme-treatment. High beta-conglycinin compositions were found to demonstrate excellent emulsifying and gelling properties in the pH region (5.5-6.2) relevant to meat applications.Type: GrantFiled: October 7, 1998Date of Patent: January 9, 2001Assignee: Monsanto CompanyInventor: Neal A. Bringe
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Patent number: 5961953Abstract: The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of contrast agents in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention to a patient and obtaining an image.Type: GrantFiled: January 16, 1998Date of Patent: October 5, 1999Assignee: Mallinckrodt Inc.Inventor: Steven R. Woulfe
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Patent number: 5888476Abstract: The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of contrast agents in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention to a patient and obtaining an image.Type: GrantFiled: November 13, 1996Date of Patent: March 30, 1999Assignee: Mallinckrodt Medical, Inc.Inventor: Steven R. Woulfe
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Patent number: 5752603Abstract: The invention relates to a reservoir for at least one capsule for oral administration which comprises a substance which is dangerous for the environment, in particular a radioactive composition, which reservoir can be enclosed within an at least substantially cylindrical shielding sleeve, has a closed bottom and can be closed at its open upper end by means of a cap, the reservoir internally comprising a plurality of longitudinal ribs. The reservoir is prefereably constructed so that it is locked against rotation within the shielding sleeve. The invention further relates to a shielded holder comprising the last-mentioned locked reservoir and a shielding sleeve having a bottom portion with an internal cross-section which is triangular to dodecagonal or forms a segment of a circle.Type: GrantFiled: November 22, 1996Date of Patent: May 19, 1998Assignee: Mallinckrodt Medical, Inc.Inventor: Mathijs Faber
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Patent number: 5746007Abstract: The present invention relates to improved drying techniques which increase the capacity and efficiency of agitated pan type dryers. In particular, the present invention relates to an agitated pan type dryer apparatus and method for aggressive convective drying of hard to dry chemical compounds, such as pharmaceuticals. The aggressive drying is brought about by creating turbulence within the drying vessel during the drying cycle. Significant reductions in drying cycle times have been achieved.Type: GrantFiled: May 3, 1996Date of Patent: May 5, 1998Inventor: Len W. Haleen
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Patent number: 5723104Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.Type: GrantFiled: May 13, 1996Date of Patent: March 3, 1998Inventors: Ella Y. Fung, Raghavan Rajagopalan
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Patent number: 5709845Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1-C.sub.10 aryl, C.Type: GrantFiled: May 13, 1996Date of Patent: January 20, 1998Inventors: Raghavan Rajagopalan, Ella Y. Fung
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Patent number: 5693308Abstract: The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image.Type: GrantFiled: February 21, 1996Date of Patent: December 2, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Dennis A. Moore, Stephen R. Cooper, Rebecca Abernathy Wallace, Michael R. Hynes
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Patent number: 5690908Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.Type: GrantFiled: November 13, 1995Date of Patent: November 25, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet Braddock Wilking, Linda Meeh, Steven R. Woulfe
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Patent number: 5672332Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 allkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.Type: GrantFiled: May 13, 1996Date of Patent: September 30, 1997Assignee: Mallinckrodt Medical, Inc.Inventors: Ella Y. Fung, Raghavan Rajagopalan