Patents Represented by Attorney, Agent or Law Firm Brian K. Stierwalt
  • Patent number: 6653530
    Abstract: Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid and tocopherol levels in oilseed plants, and in providing desirable high oleic acid seed oils.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: November 25, 2003
    Assignee: Calgene LLC
    Inventors: Christine K. Shewmaker, B. Ganesh Bhat, Mylavaraapu Venkatramesh, Shaukat H. Rangwala, Ganesh M. Kishore, Sekhar S. Boddupalli
  • Patent number: 6541259
    Abstract: Nucleic acid sequences and methods are provided for producing plants and seeds having altered tocopherol content and compositions. The methods find particular use in increasing the tocopherol levels in plants, and in providing desirable tocopherol compositions in a host plant cell.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: April 1, 2003
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Beth Savidge, Timothy Mitsky, James Weiss, Martha Ann Post-Beittenmiller
  • Patent number: 6506565
    Abstract: The present invention relates to nucleic acid sequences for regulating gene expression in plants. In particular, the invention relates to 5′ regulatory sequences which are useful for regulating expression of heterologous DNAs in plants and methods for identifying multiple 5′ regulatory sequences which confer a particular expression profile when operably linked to DNA sequences. The invention also relates to expression vectors containing the 5′ regulatory sequences and to transgenic plants containing the expression vectors.
    Type: Grant
    Filed: August 30, 2000
    Date of Patent: January 14, 2003
    Assignee: Monsanto Technology LLC
    Inventors: Timothy W. Conner, Iris Tzafrir
  • Patent number: 6495739
    Abstract: By this invention, novel nucleic acid sequences encoding for phosphatidic acid phosphatase (PAP) proteins are provided, wherein PAP protein is active in the formation of diacylglycerol from phosphatidic acid. Also considered are amino acid and nucleic acid sequences obtainable from PAP nucleic acid sequences and the use of such sequences to provide transgenic host cells capable of producing altered lipid compositions and total lipid levels.
    Type: Grant
    Filed: July 23, 1999
    Date of Patent: December 17, 2002
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Diane M. Ruezinsky
  • Patent number: 6489461
    Abstract: The invention provides novel polynucleotide and polypeptide sequences involved in fatty acid beta-oxidation and to methods of producing such polypeptides using recombinannt techniques. In addition, methods are provided for using such sequences to alter lipid levels in plants by altering fatty acid beat-oxidation in host plant cells.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: December 3, 2002
    Assignee: Calgene LLC
    Inventors: Katayoon Dehesh, Byron Froman
  • Patent number: 6444876
    Abstract: By this invention, novel nucleic acid sequences encoding for acyl-CoA: cholesterol acyltransferase (ACAT) related proteins are provided, wherein ACAT-like protein is active in the formation of a sterol ester and/or triacylylgycerol from a fatty acyl-CoA and sterol and/or diacylglycerol substrates. Also considered are amino acid and nucleic acid sequences obtainable from ACAT-like nucleic acid sequences and the use of such sequences to provide transgenic host cells capable of producing sterol esters and/or triacylglycerols.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: September 3, 2002
    Assignee: Calgene LLC
    Inventors: Michael W. Lassner, Diane M. Ruezinsky
  • Patent number: 6429356
    Abstract: Methods are provided for producing plants and seeds having altered carotenoid, fatty acid and tocopherol compositions. The methods find particular use in increasing the carotenoid levels in oilseed plants and in providing desirable high oleic acid seed oils.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: August 6, 2002
    Assignee: Calgene LLC
    Inventor: Christine K. Shewmaker
  • Patent number: 6380466
    Abstract: Rapeseed in plants producing rapeseed which have a yellow-seed coat are provided. The yellow-seed coat is controlled by a single locus mutation. Plants from the rapeseed are useful for transferring the trait into elite lines of canola.
    Type: Grant
    Filed: May 4, 1998
    Date of Patent: April 30, 2002
    Assignee: Calgene LLC
    Inventor: Daniel Facciotti
  • Patent number: 6380462
    Abstract: This invention relates to a method for increasing stearate as a component of total triglycerides found in soybean seed. The method generally comprises growing a soybean plant having integrated into its genome a DNA construct comprising, in the 5′ to 3′ direction of transcription, a promoter functional in a soybean plant seed cell, a DNA sequence encoding an acyl-ACP thioesterase protein having substantial activity on C18:0 acyl-ACP substrates, and a transcription termination region functional in a plant cell. The present invention also provides a soybean seed with about 33 weight percent or greater stearate as a component of total fatty acids found in seed triglycerides.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: April 30, 2002
    Assignee: Calgene LLC
    Inventor: Jean Kridl
  • Patent number: 6365802
    Abstract: This invention relates to a method for increasing stearate as a component of total triglycerides found in soybean seed. The method generally comprises growing a soybean plant having integrated into its genome a DNA construct comprising, in the 5′ to 3′ direction of transcription, a promoter functional in a soybean plant seed cell, a DNA sequence encoding an acyl-ACP thioesterase protein having substantial activity on C18:0 acyl-ACP substrates, and a transcription termination region functional in a plant cell. The present invention also provides a soybean seed with about 33 weight percent or greater stearate as a component of total fatty acids found in seed triglycerides.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: April 2, 2002
    Assignee: Calgene LLC
    Inventor: Jean C. Kridl
  • Patent number: 6171640
    Abstract: The utility of soybeans having a composition of greater than 40% of the protein as beta-conglycinin and less than 10% of the protein as glycinin for making highly functional high beta-conglycinin compositions was discovered. The discovered ingredients are useful for mimicking the texturizing properties of casein while also maintaining or improving physiological benefits of soy protein ingredients (e.g., cholesterol and triglyceride lowering properties). The high stability of the high beta-conglycinin compositions against protein-protein aggregation reactions is valuable for creating good tasting beverages and beverage mixes. Cheese with good spreadability, gloss and smoothness was made using an enzyme-modified version of the new ingredient composition. Cheese with good firmness and meltability was also created using a different enzyme-treatment. High beta-conglycinin compositions were found to demonstrate excellent emulsifying and gelling properties in the pH region (5.5-6.2) relevant to meat applications.
    Type: Grant
    Filed: October 7, 1998
    Date of Patent: January 9, 2001
    Assignee: Monsanto Company
    Inventor: Neal A. Bringe
  • Patent number: 5961953
    Abstract: The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of contrast agents in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention to a patient and obtaining an image.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: October 5, 1999
    Assignee: Mallinckrodt Inc.
    Inventor: Steven R. Woulfe
  • Patent number: 5888476
    Abstract: The present invention provides compositions comprising contrast agents capable of binding non-covalently to blood proteins. The compositions of the invention provide increased residence time of contrast agents in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention to a patient and obtaining an image.
    Type: Grant
    Filed: November 13, 1996
    Date of Patent: March 30, 1999
    Assignee: Mallinckrodt Medical, Inc.
    Inventor: Steven R. Woulfe
  • Patent number: 5752603
    Abstract: The invention relates to a reservoir for at least one capsule for oral administration which comprises a substance which is dangerous for the environment, in particular a radioactive composition, which reservoir can be enclosed within an at least substantially cylindrical shielding sleeve, has a closed bottom and can be closed at its open upper end by means of a cap, the reservoir internally comprising a plurality of longitudinal ribs. The reservoir is prefereably constructed so that it is locked against rotation within the shielding sleeve. The invention further relates to a shielded holder comprising the last-mentioned locked reservoir and a shielding sleeve having a bottom portion with an internal cross-section which is triangular to dodecagonal or forms a segment of a circle.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: May 19, 1998
    Assignee: Mallinckrodt Medical, Inc.
    Inventor: Mathijs Faber
  • Patent number: 5746007
    Abstract: The present invention relates to improved drying techniques which increase the capacity and efficiency of agitated pan type dryers. In particular, the present invention relates to an agitated pan type dryer apparatus and method for aggressive convective drying of hard to dry chemical compounds, such as pharmaceuticals. The aggressive drying is brought about by creating turbulence within the drying vessel during the drying cycle. Significant reductions in drying cycle times have been achieved.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: May 5, 1998
    Inventor: Len W. Haleen
  • Patent number: 5723104
    Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: March 3, 1998
    Inventors: Ella Y. Fung, Raghavan Rajagopalan
  • Patent number: 5709845
    Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1-C.sub.10 aryl, C.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: January 20, 1998
    Inventors: Raghavan Rajagopalan, Ella Y. Fung
  • Patent number: 5693308
    Abstract: The present invention provides compositions comprising a contrast agent capable of reversibly binding to thiol groups of blood-borne proteins. The compositions of the invention provide increased residence time of the contrast agent in the vasculature, thus providing effective blood pool contrast agents. The invention also provides methods for imaging a patient comprising administering a composition of the invention and obtaining an image.
    Type: Grant
    Filed: February 21, 1996
    Date of Patent: December 2, 1997
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Dennis A. Moore, Stephen R. Cooper, Rebecca Abernathy Wallace, Michael R. Hynes
  • Patent number: 5690908
    Abstract: Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging.
    Type: Grant
    Filed: November 13, 1995
    Date of Patent: November 25, 1997
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Edward A. Deutsch, Karen F. Deutsch, William P. Cacheris, William H. Ralston, David H. White, Dennis L. Nosco, Robert G. Wolfangel, Janet Braddock Wilking, Linda Meeh, Steven R. Woulfe
  • Patent number: 5672333
    Abstract: This invention provides functional dyes of the general formula: ##STR1## wherein R1, R2, and R.sup.5 may be the same or different and are selected from the group consisting of hydrogen, C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxyl, hydroxyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, carboxyl, C.sub.1 -C.sub.10 carboxylalkyl, halogen, nitro, C.sub.1 -C.sub.10 alkoxycarbonyl, mercapto, C.sub.1 -C.sub.10 mercaptoalkyl, C.sub.1 -C.sub.10 alkylthio, sulfonate, and --(CH.sub.2).sub.m --N(R.sup.6)(R.sup.7) wherein R.sup.6 and R.sup.7 are independently hydrogen or C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 acyl, and R.sup.6 and R.sup.7 are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with --O--, --NR.sup.8, or --S--; R.sup.3 and R.sup.4 may be the same or different and are selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 hydroxyalkyl, C.sub.1 -C.sub.10 alkoxyalkyl, C.sub.1 -C.sub.10 aryl, C.sub.1 -C.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: September 30, 1997
    Assignee: Mallinckrodt Medical, Inc.
    Inventors: Raghavan Rajagopalan, Ella Y. Fung